Results 121 to 130 of about 13,707 (310)

Cost-effectiveness analysis of the use of mepolizumab in omalizumab-resistant patients with severe asthma

Качественная клиническая практика, 2019
Objective. To determine the clinical and economic consequences of the drug mepolizumab in patients with severe bronchial asthma (SBA) and the ineff ectiveness of omalizumab. Methods.
A. G. Tolkushin, V. A. Rogov, D. A. Ivanov, N. L. Pogudina   +3 more
doaj   +1 more source

Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme [PDF]

, 2015
BACKGROUND : The most prevalent phenotype of asthma is characterized by eosinophil-dominated inflammation that is driven by a type 2 helper T cell (Th2).
Bachert, Claus, Beeh, Kai M, Bille, Joachim, Buhl, Roland, Garn, Holger, Hohlfeld, Jens M, Homburg, Ursula, Ignatenko, Stanislav, Kappeler, Dominik, Kirsten, Anne-Marie, Korn, Stephanie, Kornmann, Oliver, Krug, Norbert, Renz, Harald, Renz, Jonas, Rogon, Cordelia, Timmer, Wolfgang, Turowska, Agnieszka, Werfel, Thomas, Zeitvogel, Jana, Zhang, Nan   +20 more
core   +2 more sources

Mepolizumab for Eosinophilic COPD [PDF]

New England Journal of Medicine, 2018
Frank C. Sciurba, Eric S. Bradford, Ian D. Pavord   +2 more
openaire   +5 more sources

A Case of Eosinophilic Gastroenteritis Remission Achieved Steroid-Free With Mepolizumab

Gastro Hep Advances, 2022
Eosinophilic gastroenteritis is an eosinophilic inflammatory disease that responds well to steroids but often relapses upon their discontinuation, necessitating maintenance treatment.
Yuki Hirata, Takahiko Nakamura, Kazuhide Higuchi   +2 more
doaj  

Usability of mepolizumab single-use prefilled autoinjector for patient self-administration [PDF]

, 2019
Objective: To evaluate usability of mepolizumab as a liquid drug product self-administered via a single-use prefilled autoinjector (AI) by patients with severe eosinophilic asthma (SEA), or their caregivers, in-clinic and at home.
Bentley, JH, Bernstein, D, Bradford, E, Chapman, KR, Follows, R, Pavord, Ian, Pouliquen, I   +6 more
core   +2 more sources

Budget Impact Analysis of Mepolizumab for Eligible Patients in the Setting of a Severe Asthma Clinic Within Dubai Health Authority (DHA)

ClinicoEconomics and Outcomes Research, 2022
Bassam Mahboub,1 Ahmed Mohy,2 Islam El-Amir,2 Tamara Lukić,3 Raef Gouhar,4 Saeed Noibi5 1Pulmonary Medicine Department, Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates; 2Medical Affairs Department, GSK, Jeddah, Kingdom of ...
Mahboub B, Mohy A, El-Amir I, Lukić T, Gouhar R, Noibi S   +5 more
doaj  

Effective treatment with mepolizumab in a patient with severe eosinophilic granulomatosis with polyangiitis complicated with small intestine perforation

Respiratory Medicine Case Reports, 2023
Eosinophilic granulomatosis with polyangiitis (EGPA) is systemic vasculitis caused by eosinophilia affecting small to medium-sized blood vessels, which damages the organs.
Mari Sato, Masakiyo Yatomi, Ikuo Wakamatsu, Shogo Uno, Chiharu Hanazato, Tomomi Masuda, Koichi Yamaguchi, Haruka Aoki-Saito, Norimitsu Kasahara, Yosuke Miura, Hiroaki Tsurumaki, Kenichiro Hara, Yasuhiko Koga, Noriaki Sunaga, Takuhisa Okada, Hayato Ikota, Takeshi Hisada, Toshitaka Maeno   +17 more
doaj  

Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study [PDF]

, 2016
BACKGROUND: Asthma is a biologically heterogeneous disease and development of novel therapeutics requires understanding of pathophysiologic phenotypes. There is uncertainty regarding the stability of clinical characteristics and biomarkers in asthma over
C. Porsbjerg, D. Singh, E. S. Barnathan, F. Baribaud, J. M. FitzGerald, J. N. Kline, M. J. Loza, M. Laviolette, null null, P. Berger, P. Chanez, P. E. Silkoff, P. O. Girodet, S. Kelsen, S. Khatri, V. Backer, V. S. Susulic   +16 more
core   +1 more source

Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys [PDF]

, 2001
Timothy K. Hart, Richard M. Cook, Parnian Zia‐Amirhosseini, Elisabeth A. Minthorn, Teresa S. Sellers, Beverly E. Maleeff, Scot Eustis, Lester W. Schwartz, Ping Tsui, Edward R. Appelbaum, Elise C. Martin, Peter J. Bugelski, Danuta J. Herzyk   +12 more
openalex   +1 more source

Severe Atopic Dermatitis In Spain: A Real-Life Observational Study [PDF]

, 2019
Objective: To determine the epidemiology and characterize the treatment prescribed for severe atopic dermatitis (AD) in children/adults in usual clinical practice.
Armario Hita, José Carlos, Navarro-Artieda, Ruth, Sicras-Mainar, Antoni   +2 more
core   +2 more sources