UPLC-MS/MS Method for Simultaneous Determination of Three Major Metabolites of Mequindox in Holothurian [PDF]
Journal of Analytical Methods in Chemistry, 2018 This study developed an ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the detection of three major metabolites of mequindox, including 3-methyl-quinoxaline-2-carboxylic acid, 1-desoxymequindox, and 1,4 ...
Huihui Liu +9 more
doaj +6 more sources
Mequindox Induced Genotoxicity and Carcinogenicity in Mice [PDF]
Frontiers in Pharmacology, 2018 Mequindox (MEQ), acting as an inhibitor of deoxyribonucleic acid (DNA) synthesis, is a synthetic heterocyclic N-oxides. To investigate the potential carcinogenicity of MEQ, four groups of Kun-Ming (KM) mice (50 mice/sex/group) were fed with diets ...
Qianying Liu +14 more
doaj +7 more sources
Metabolism Profile of Mequindox in Sea Cucumbers In Vivo Using LC-HRMS [PDF]
Antibiotics, 2022 In this work, the metabolism behavior of mequindox (MEQ) in sea cucumber in vivo was investigated using LC-HRMS. In total, nine metabolites were detected and identified as well as the precursor in sea cucumber tissues.
Xin Mao +8 more
doaj +4 more sources
The Reproductive Toxicity of Mequindox in a Two-Generation Study in Wistar Rats [PDF]
Frontiers in Pharmacology, 2018 Mequindox (MEQ), belonging to quinoxaline-di-N-oxides (QdNOs), has been extensively used as a synthetic antibacterial agent. To evaluate the reproductive toxicity of MEQ, different concentrations of MEQ were administered to Wistar rats by feeding diets ...
Qianying Liu +12 more
doaj +5 more sources
Mechanisms of the Testis Toxicity Induced by Chronic Exposure to Mequindox [PDF]
Frontiers in Pharmacology, 2017 Mequindox (MEQ) is a synthetic antimicrobial agent widely used in China since the 1980s. Although the toxicity of MEQ is well recognized, its testis toxicity has not been adequately investigated.
Qianying Liu +9 more
doaj +5 more sources
Effects of
BMC Veterinary Research, 2012 Background Lactobacillus plantarum is a plant-associated bacterial species but it has also been found in human, mouse and porcine gastrointestinal tracts.
Suo Cheng +6 more
doaj +5 more sources
Mequindox-Induced Kidney Toxicity Is Associated With Oxidative Stress and Apoptosis in the Mouse [PDF]
Frontiers in Pharmacology, 2018 Mequindox (MEQ), belonging to quinoxaline-di-N-oxides (QdNOs), is a synthetic antimicrobial agent widely used in China. Previous studies found that the kidney was one of the main toxic target organs of the QdNOs.
Qianying Liu +16 more
doaj +5 more sources
Natural occurrences and characterization of Elizabethkingia miricola infection in cultured bullfrogs (Rana catesbeiana) [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionThe bacterium Elizabethkingia miricola is a multispecies pathogen associated with meningitis-like disease that has been isolated from several amphibian species, including the bullfrog, but this is the first isolation in Guangxi.
Dongdong Wei +14 more
doaj +2 more sources
Comparison of Antimicrobial Resistance, Virulence Genes, Phylogroups, and Biofilm Formation of Escherichia coli Isolated From Intensive Farming and Free-Range Sheep [PDF]
Frontiers in Microbiology, 2021 Pathogenic E. coli are among the most frequently isolated bacterial pathogens on large-scale sheep farms in China. Antibiotic use in wool sheep production is a risk factor for promoting the emergence of resistant E. coli.
Xueliang Zhao +12 more
doaj +2 more sources
Olaquindox-Induced Liver Damage Involved the Crosstalk of Oxidative Stress and p53 In Vivo and In Vitro. [PDF]
Oxid Med Cell Longev, 2020 Olaquindox (OLA), a member of the quinoxaline‐N,N‐dioxide family, has been widely used as a growth‐promoting feed additive and treatment for bacterial infections. The toxicity has been a major concern, and the precise molecular mechanism remains poorly understood. The present study was aimed at investigating the roles of oxidative stress and p53 in OLA‐
Li D +8 more
europepmc +2 more sources