Corrigendum: Mequindox Induced Genotoxicity and Carcinogenicity in Mice [PDF]
Frontiers in Pharmacology, 2018 [This corrects the article DOI: 10.3389/fphar.2018.00361.].
Qianying Liu +14 more
doaj +7 more sources
Corrigendum: The Reproductive Toxicity of Mequindox in a Two-Generation Study in Wistar Rats [PDF]
Frontiers in Pharmacology, 2018 [This corrects the article DOI: 10.3389/fphar.2018.00870.].
Qianying Liu +12 more
doaj +4 more sources
Metabolism of Mequindox in Isolated Rat Liver Cells
Journal of Integrative Agriculture, 2014 Mequindox (MEQ), 3-methyl-2-quinoxalinacetyl-1,4-dioxide, is widely used in Chinese veterinary medicine as an antimicrobial agent and feed additive. Its toxicity has been reported to be closely related to its metabolism.
Guang-hui LI +5 more
doaj +2 more sources
Pharmacokinetics of mequindox after intravenous and intramuscular administration to goat [PDF]
African Journal of Biotechnology, 2016 Pharmacokinetics and bioavailability of mequindox were determined after single intravenous (i.v.) or intramuscular (i.m.) administrations of 7 mg/kg body weight (b.w.) to 10 healthy adult goats. Plasma mequindox concentrations were measured by high performance liquid chromatography.
Li, Yinqian +4 more
openaire +4 more sources
Preparation of mequindox microemulsion and its transdermal permeability in vitro
浙江大学学报. 农业与生命科学版, 2012 Aiming to develop the transdermal formulation of mequindox microemulsion (M-ME) and evaluate its stability and the transdermal permeability in vitro skin, the best prescription was optimized through the pseudoternary phase diagrams, and the M-ME was ...
WU Jing-chao +5 more
doaj +2 more sources
Systems Responses of Rats to Mequindox Revealed by Metabolic and Transcriptomic Profiling [PDF]
Journal of Proteome Research, 2012 Mequindox is used as an antibiotic drug in livestock; however, its toxicity remains largely unclear. Previously, we investigated metabolic responses of mice to mequindox exposure. In order to evaluate dependences of animal species in response to mequindox insult, we present the metabolic consequences of mequindox exposure in a rat model, by employing ...
Zhao, X +6 more
openaire +3 more sources
A Milk Extracellular Vesicle-Based Nanoplatform Enhances Combination Therapy Against Multidrug-Resistant Bacterial Infections. [PDF]
Adv Sci (Weinh)Treating multidrug‐resistant bacteria with a single antibiotic is becoming increasingly difficult, leading to a gradual rise in global infections and deaths. Here, a bio‐inspired delivery system equipped with combination therapy and paracellular transport has been proven to deliver and slowly release a combination of drugs through oral administration ...
Qu S +6 more
europepmc +2 more sources
Catalytic characteristics of CYP3A22-dependent mequindox detoxification
Catalysis Communications, 2011 Abstract The anti-bacterial agent mequindox is widely used as an animal feed additive in China. Its potential effect on host cells, however, remains largely unknown. Here, we report that pig CYP3A22 represents an important metabolic enzyme in mequindox catalysis.
Liu, J +8 more
openaire +4 more sources
Reduction and Hydroxylation Metabolites of Mequindox in Holothurian Analysis by Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry [PDF]
Journal of Chromatographic Science, 2022 AbstractThis research proposed and validated an LC-MSMS method for five reduction and hydroxylation metabolites of Mequindox (MEQ) as well as the precursor in holothurian samples. Specially, three hydroxylation metabolites (2-isoethanol-mequindox, M3, 2-isoethanol-1-desoxymequindox, M4 and 2-isoethanol-4-desoxymequindox, M5) are novel for analysis ...
Yonggang Li +8 more
openaire +3 more sources
Mequindox induced cellular DNA damage via generation of reactive oxygen species
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2012 Mequindox, a quinoxaline-N-dioxide derivative that possesses antibacterial properties, has been widely used as a feed additive in the stockbreeding industry in China. While recent pharmacological studies have uncovered potential hazardous effects of mequindox, exactly how mequindox induces pathological changes and the cellular responses associated with
Yang, Q +10 more
openaire +5 more sources