Metabolism of Mequindox in Isolated Rat Liver Cells
Journal of Integrative Agriculture, 2014 Mequindox (MEQ), 3-methyl-2-quinoxalinacetyl-1,4-dioxide, is widely used in Chinese veterinary medicine as an antimicrobial agent and feed additive. Its toxicity has been reported to be closely related to its metabolism.
Guang-hui LI +5 more
doaj +3 more sources
Toxic metabolites, Sertoli cells and Y chromosome related genes are potentially linked to the reproductive toxicity induced by mequindox. [PDF]
Oncotarget, 2017 Mequindox (MEQ) is a relatively new synthetic antibacterial agent widely applied in China since the 1980s. However, its reproductive toxicity has not been adequately performed.
Liu Q, Lei Z, Dai M, Wang X, Yuan Z.
europepmc +5 more sources
Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox. [PDF]
Sci Rep, 2017 Mequindox (MEQ) is a synthetic antimicrobial agent of quinoxaline-1,4-dioxide group (QdNOs). The liver is regarded as the toxicity target of QdNOs, and the role of N → O group-associated various toxicities mediated by QdNOs is well recognized.
Liu Q +8 more
europepmc +5 more sources
Reduction and Hydroxylation Metabolites of Mequindox in Holothurian Analysis by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry. [PDF]
Journal of Chromatographic Science, 2022 This research proposed and validated an LC-MSMS method for five reduction and hydroxylation metabolites of Mequindox (MEQ) as well as the precursor in holothurian samples.
Yonggang Li +8 more
semanticscholar +4 more sources
Systems responses of rats to mequindox revealed by metabolic and transcriptomic profiling. [PDF]
Journal of Proteome Research, 2012 Mequindox is used as an antibiotic drug in livestock; however, its toxicity remains largely unclear. Previously, we investigated metabolic responses of mice to mequindox exposure.
Xiuju Zhao +6 more
semanticscholar +4 more sources
Mequindox induced cellular DNA damage via generation of reactive oxygen species.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2012 Mequindox, a quinoxaline-N-dioxide derivative that possesses antibacterial properties, has been widely used as a feed additive in the stockbreeding industry in China.
Jing Liu +10 more
semanticscholar +6 more sources
Catalytic characteristics of CYP3A22-dependent mequindox detoxification
Catalysis Communications, 2011 The anti-bacterial agent mequindox is widely used as an animal feed additive in China. Its potential effect on host cells, however, remains largely unknown. Here, we report that pig CYP3A22 represents an important metabolic enzyme in mequindox catalysis.
Jing Liu +8 more
semanticscholar +5 more sources
Comparison of Antimicrobial Resistance, Virulence Genes, Phylogroups, and Biofilm Formation of Escherichia coli Isolated From Intensive Farming and Free-Range Sheep [PDF]
Frontiers in Microbiology, 2021 Pathogenic E. coli are among the most frequently isolated bacterial pathogens on large-scale sheep farms in China. Antibiotic use in wool sheep production is a risk factor for promoting the emergence of resistant E. coli.
Xueliang Zhao +12 more
doaj +2 more sources
Preparation of mequindox microemulsion and its transdermal permeability in vitro
浙江大学学报. 农业与生命科学版, 2012 Aiming to develop the transdermal formulation of mequindox microemulsion (M-ME) and evaluate its stability and the transdermal permeability in vitro skin, the best prescription was optimized through the pseudoternary phase diagrams, and the M-ME was ...
WU Jing-chao +5 more
doaj +2 more sources
Pharmacokinetics of mequindox after intravenous and intramuscular administration to goat [PDF]
African Journal of Biotechnology, 2016 Pharmacokinetics and bioavailability of mequindox were determined after single intravenous (i.v.) or intramuscular (i.m.) administrations of 7 mg/kg body weight (b.w.) to 10 healthy adult goats.
Hao, Caiju +4 more
core +4 more sources