DEVELOPMENT OF COMPUTATIONAL TOOLS TO STUDY THE PATTERNING OF DNA AND RNA METHYLATION IN HEALTHY AND DISEASE STATES [PDF]
, 2016 Epigenetics can be defined as the set of sequence independent processes that produces heritable changes in cellular information. These chromatin-based events such as covalent modification of DNA and histone tails are laid down by the co-ordinated action ...
K. Kishore
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MeRIP-seq detects temperature related variation in methylated environmental RNA in fish
Abstract Environmental RNA (eRNA) enables non-invasive, near-real-time and potentially functional insight into aquatic communities by capturing RNA molecules released by living organisms. While most eRNA studies focus solely on transcript abundance, this overlooks other regulatory layers that shape how organisms ...
Ehsan Pashay Ahi +3 more
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ToxicsBackground: N6-methyladenosine (m6A) modification plays a crucial role in the regulation of diverse cellular processes influenced by environmental factors. Nevertheless, the involvement of m6A-modified long noncoding RNAs (lncRNAs) in the pathogenesis of
Yingying Zeng +7 more
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Recent advances in noncoding RNA modifications of gastrointestinal cancer [PDF]
Hara T., Meng S., Arao Y., et al. Recent advances in noncoding RNA modifications of gastrointestinal cancer. Cancer Science, (2024); https://doi.org/10.1111/cas.16380.Elucidating the mechanisms underlying cancer development and proliferation is ...
Arao, Yasuko +10 more
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The m6A methylation and expression profiles of mouse neural stem cells after hypoxia/reoxygenation
Stem Cell Research & TherapyBackground Ischemia–reperfusion injury to the central nervous system often causes severe complications. The activation of endogenous neural stem cells (NSCs) is considered a promising therapeutic strategy for nerve repair.
Shaoqiong Zhang +6 more
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N6-methyladenosine RNA landscape in the aged mouse hearts [PDF]
ObjectiveCardiac aging is a major risk factor for the development of cardiovascular diseases. Although evidence suggests an association between N6-methyladenosine (m6A) modification and numerous cardiovascular diseases, its role in cardiac aging remains ...
Hai-Liang Mo +12 more
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FTO Facilitates Cervical Cancer Malignancy Through Inducing m6A‐Demethylation of PIK3R3 mRNA
Cancer MedicineBackground The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6‐methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity‐associated gene (FTO) works as the m6A ...
Bingxin Chen +6 more
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MdDSK2a-Like-MdMTA module functions in apple cold response via regulating ROS detoxification and cell wall deposition [PDF]
N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotic cells. Although the importance of its roles in mRNA metabolism, plant development, and stress responses has been well documented, regulation of its machinery is largely
Bao C. +18 more
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The dark side of the epitranscriptome : chemical modifications in long non-coding RNAs [PDF]
, 2017 The broad application of next-generation sequencing technologies in conjunction with improved bioinformatics has helped to illuminate the complexity of the transcriptome, both in terms of quantity and variety.
Gutschner, Tony +2 more
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ALKBH5 regulates chicken adipogenesis by mediating LCAT mRNA stability depending on m6A modification
BMC GenomicsBackground Previous studies have demonstrated the role of N6-methyladenosine (m6A) RNA methylation in various biological processes, our research is the first to elucidate its specific impact on LCAT mRNA stability and adipogenesis in poultry. Results The
Xiaohuan Chao +14 more
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