Results 121 to 130 of about 152,412 (174)

The Oncogenic Role of UBXN1 in Gastric Cancer Is Attributed to the METTL16‐Mediated m6A Methylation and Histone Modifications

Cancer Medicine
Background Multiple epigenetic regulatory mechanisms are crucial in tumorigenesis and development. However, the synergistic relationship between N6‐methyladenosine (m6A) and histone modifications in regulating gene expression of gastric cancer (GC ...
Kesong Shi, Yani Chen, Tian Gao, Hua Guo, Xinyao Fu, Yuan Wu, Haiquan Yu   +6 more
doaj   +1 more source

YTHDF2 enhances proliferation and metastasis of nasopharyngeal carcinoma by mediating m6A modification in destabilizing FOXO1 mRNA

Cancer Biology & Therapy
Background Aberrant N6-methyladenosine (m6A) modification is linked to cancer development and progression. However, the role of YTH N6-methyladenosine RNA binding protein F2 (YTHDF2), an m6A ‘reader protein’, in nasopharyngeal carcinoma (NPC) is poorly ...
Peng Yu, Wenyang Wei, Xinyun Peng, Jiemei Ye, Yuanli Ji, Bin Zhang, Yonglin Cai   +6 more
doaj   +1 more source

Integrate Analysis of MeRIP-seq and RNA-seq Reveals METTL14 as a Core Regulator of Follicular Granulosa Cell Development in Zi Geese

m6A is a ubiquitous reversible post-transcriptional RNA methylation modification in eukaryotic cells, which has been positive effect on regulating follicles development in animals. However, the role of m6A modification profiling in regulating the development of healthy and atresia small yellow follicle have not yet been studied in poultry.
Jinbo Zhao, Jiaqiang Dong, Hong Zhang, Kun Yang, Mingdong Huo, Niandong Wei, Long Fu, Wenjiang Zhao, Hongbao Wang, Zhigang Ma, Zhifeng Chen   +10 more
openaire   +1 more source

Ythdf2 Accelerates Lymphangiogenesis In Oscc Through Rnf43/Wnt5b Pathway

International Dental Journal
Aim or purpose: The aim of this study is to investigate the role of N6-methyladenosine (m6A), the most abundant intrinsic mRNA modification in eukaryotes, in lymphangiogenesis and lymphatic metastasis in oral squamous cell carcinoma (OSCC). Materials and
Tianjiao Li
doaj   +1 more source

Script_RNA-seq

, 2016
R script for RNA-seq ...
Juergen Heinze (3256044), Katharina von Wyschetzki (3266517), Helena Lowack (3266520)   +2 more
core   +1 more source

RNA methyltransferase 3 drives pancreatic acinar cell carcinoma growth and is a therapeutic target

Signal Transduction and Targeted Therapy
Pancreatic acinar cell carcinoma (ACC) is a rare and aggressive malignancy whose molecular basis remains poorly understood. N6-methyladenosine (m⁶A) RNA modification, mediated particularly through methyltransferase 3 (METTL3), has emerged as a critical ...
Shotaro Tatekawa, Tomoaki Hara, Sikun Meng, Tetsuya Sato, Takahiro Arai, Keisuke Tamari, Yasuko Arao, Yoshiko Tsuji, Masamitsu Konno, Ken Ofusa, Koji Kitamura, Sarah Rennie, Motoharu Inui, Daisuke Taguchi, Hirofumi Akita, Daisuke Motooka, Yoshiki Murakumo, Hidenori Inohara, Yuichiro Doki, Hidetoshi Eguchi, Kazuhiko Ogawa, Hideshi Ishii   +21 more
doaj   +1 more source

METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus

BMC Medicine
Background Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown cause. N6-methyladenosine (m6A) is the most common mRNA modification and participates in various immune processes such as interferon production and immune cell regulation ...
Yu Liu, Xiaohua Wang, Mingcheng Huang, Ailing Luo, Shanshan Liu, Mansi Cai, Weinian Li, Shiwen Yuan, Zhihua Zheng, Xiaoping Liu, Chun Tang   +10 more
doaj   +1 more source

Additional file 1 of Construction of RNA m6A profiles in liver tissue of mice in sepsis-induced liver injury based on m6A MeRIP-seq and RNA-seq

Supplementary material 1.
Li, Li, Li, Penghui, He, Yuhua, Xu, Ziyi, Fan, Yitao, Jia, Xueying, Liu, Yingru, Qin, Lijie   +7 more
openaire   +1 more source

Informative sequence-based models for fragment distributions in ChIP-seq, RNA-seq and ChIP-chip data [PDF]

Many high throughput sequencing protocols for RNA and DNA require that the polynucleic acid is fragmented so that the identity of a limited number of nucleic acids of one or both of the ends of the fragments can be determined by sequencing. The nucleic
Dyer, Nigel
core  

GPRC5B Identified by m5C meRIP-Seq Suppresses Apoptosis in Osteosarcoma Through NSUN2-Mediated RNA Methylation. [PDF]

Cancer Sci
Chen Z, Yang M, Liang X, Yang Z, Mai W, Wang Y, Lu Y, Wang R, Han Y, Xie Y, Cai L.   +10 more
europepmc   +1 more source