Results 101 to 110 of about 152,412 (174)

MeRIP-seq detects temperature related variation in methylated environmental RNA in fish

Abstract Environmental RNA (eRNA) enables non-invasive, near-real-time and potentially functional insight into aquatic communities by capturing RNA molecules released by living organisms. While most eRNA studies focus solely on transcript abundance, this overlooks other regulatory layers that shape how organisms ...
Ehsan Pashay Ahi, Spiros Papakostas, Aristotelis Moulistanos, Tamara Schenekar   +3 more
openaire   +1 more source

Interrogating the Escherichia coli Epitranscriptome Via CRISPR Interference and Nanopore Native RNA Sequencing

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Epitranscriptomics is understudied in bacteria but has the ability to modulate antimicrobial resistance, virulence and pathogenicity. Pitt et al. implement two cutting‐edge techniques: CRISPR interference and Nanopore direct RNA sequencing along with functional assays to study RNA modifications in Escherichia coli.
Miranda E. Pitt, Jianshu Zhang, An N. T. Nguyen, Michael B. Hall, Leila Jebeli, Leo A. Featherstone, Garry S. A. Myers, Nichollas E. Scott, Lachlan J. M. Coin   +8 more
wiley   +1 more source

A comprehensive analysis of differential RNA m6A methylation modifications across the entire transcriptome in PTSD through high-throughput MeRIP sequencing

Brain Research Bulletin
In recent years, the increasing frequency of traumatic events has drawn greater attention to post-traumatic stress disorder (PTSD). However, its underlying biological mechanisms remain poorly understood.
Luodong Yang, Jiaying Lu, Keke Lu, Min Hu, Guiqing Zhang   +4 more
doaj   +1 more source

Hypothalamus Participates in Peripheral Sympathetic Hyperactivity After Acute Brain Injury by Regulating Trhr M6A Modification

MedComm, Volume 7, Issue 10, October 2026.
In acute brain injury (TBI/ICH), sympathetic hyperactivity is driven by hypothalamic FTO upregulation. FTO demethylates Trhr, blocking m6A‐YTHDF2‐dependent degradation, which stabilizes Trhr mRNA and increases neuronal sensitivity to TRH. Restoring FTO or Trhr alleviates sympathetic hyperactivity, offering a potential target for managing autonomic ...
Maoxing Fei, Handong Wang, Chaochao Gao, Shiqiao Luo, Xiwen Huang, Yanling Han, Mengliang Zhou, Zhenxing Li   +7 more
wiley   +1 more source

DNMT1 Regulates Testosterone Synthesis in Aged Rat Leydig Cells via FTO‐Mediated HSP90AA1 m6A Levels

Aging Cell, Volume 25, Issue 10, October 2026.
During Leydig cell senescence, decreased DNMT1 triggers Fto promoter hypomethylation and upregulates FTO. Elevated FTO reduces m6A modification of Hsp90aa1, lowering HSP90AA1 to inhibit AKT signaling, facilitate apoptosis and reduce testosterone synthesis.
Yaqi Li, Yulei Duan, Zihang Tian, Yibing Gao, Yufei Qiao, Shuang Zhao, Wenyan Li, Zheng Gao, Siyun Niu   +8 more
wiley   +1 more source

N6‐Methyladenosine Demethylase FTO Protects Pancreatic ΒTC6 Cells From Cholesterol‐Triggered Damage by Regulating Nfatc4: Insights From RNA‐Seq Analysis

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
FTO Protects Mouse Pancreatic Beta‐TC‐6 cells From Cholesterol‐Triggered Damage by Repressing Nfatc4. ABSTRACT Excessive cholesterol contributes to pancreatic β‐cell dysfunction and plays a critical role in the pathogenesis of metabolic disorders.
Pingping Hong, Yongjie Li, Jiandong Lin, Lingxiao Wang, Xiaofang Fan, Hongfang Wang, Luping Lou   +6 more
wiley   +1 more source

The m6A methylation and expression profiles of mouse neural stem cells after hypoxia/reoxygenation

Stem Cell Research & Therapy
Background Ischemia–reperfusion injury to the central nervous system often causes severe complications. The activation of endogenous neural stem cells (NSCs) is considered a promising therapeutic strategy for nerve repair.
Shaoqiong Zhang, Kaile Cui, Yuanyuan Li, Yiting Fan, Dongxu Wang, Xingen Yao, Bo Fang   +6 more
doaj   +1 more source

Transcriptomic MeRIP-Seq data of Lupinus angustifolius roots

GENERAL INFORMATIONTitle of Dataset: Transcriptomic MeRIP-Seq data of Lupinus angustifolius rootsThe datasets contain the results of MeRIP-Seq analysis of 24 libraries, including three biological replicates for input samples [I] and after m6A ...
Kubiak, Dawid
core   +1 more source

Polyphenism Through RNA Chemical Modifications

Molecular Ecology, Volume 35, Issue 19, October 2026.
ABSTRACT Polyphenism, the capacity of a single genotype to produce discrete phenotypes in response to environmental cues, has long served as a model for understanding developmental plasticity. While classical studies have highlighted hormonal signalling and transcription‐factor‐driven gene regulatory networks that mediate these environmentally induced ...
Ralf Schneider, Ehsan Pashay Ahi
wiley   +1 more source

Transcriptome-Wide Analysis of N6-Methyladenosine-Modified Long Noncoding RNAs in Particulate Matter-Induced Lung Injury

Toxics
Background: N6-methyladenosine (m6A) modification plays a crucial role in the regulation of diverse cellular processes influenced by environmental factors. Nevertheless, the involvement of m6A-modified long noncoding RNAs (lncRNAs) in the pathogenesis of
Yingying Zeng, Guiping Zhu, Wenjun Peng, Hui Cai, Chong Lu, Ling Ye, Meiling Jin, Jian Wang   +7 more
doaj   +1 more source