Results 81 to 90 of about 152,412 (174)

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease. [PDF]

, 2013
BACKGROUND: Vitamin D insufficiency has been implicated in autoimmunity. ChIP-seq experiments using immune cell lines have shown that vitamin D receptor (VDR) binding sites are enriched near regions of the genome associated with autoimmune diseases.
Heather Hanwell, Adam E Handel, Giulio Disanto, Gavin Giovannoni, Sandve, GK, Berlanga-Taylor, AJ, Geir K Sandve, Finn Drabløs, Disanto, Giulio, Drabløs, F, Handel, Adam, Giuseppe Gallone, George C Ebers, Ramagopalan, Sreeram V, Ebers, George, Drabløs, Finn, Drablos, F, Hanwell, Heather EC, Antonio J Berlanga-Taylor, Handel, Adam E, Sandve, Geir Kjetil, Ebers, Georg C, Ramagopalan, SV, Hanwell, H, Handel, AE, Price, RN, Sreeram V Ramagopalan, Gallone, G, Ebers, GC, Gallone, Anna, Giovannoni, Gavin, Berlanga-Taylor, Antonio, Giovannoni, G, Price, Richard, Disanto, G   +34 more
core   +2 more sources

Prediction and analysis for transcriptome M6A methylation sites on MeRIP-Seq data

, 2015
This item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.Methylated RNA Immunoprecipitation combined with RNA ...
Cui, Xiaodong
core   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Synchronous profiling of mRNA N6-methyladenosine modifications and mRNA expression in high-grade serous ovarian cancer: a pilot study

Scientific Reports
This study aimed to synchronously determine epitranscriptome-wide RNA N6-methyladenosine (m6A) modifications and mRNA expression profile in high grade serous ovarian cancer (HGSOC).
Li Yang, Jingfang Liu, Yanlu Jin, Jie Xing, Jiejie Zhang, Xin Chen, Aijun Yu   +6 more
doaj   +1 more source

Statistical Tests for Detecting Differential RNA-Transcript Expression from Read Counts [PDF]

, 2010
As a fruit of the current revolution in sequencing technology, transcriptomes can now be analyzed at an unprecedented level of detail. These advances have been exploited for detecting differential expressed genes across biological samples and for ...
Gunnar Rätsch, Bohnert, R., Stegle, O., Philipp Drewe, Drewe, P., Rätsch, G., Regina Bohnert, Borgwardt, K., Oliver Stegle, Gunnar Rätsch, Karsten Borgwardt   +10 more
core   +1 more source

Results of ChIP-Seq and DNase-Seq

, 2023
Results of ChIP-Seq and DNase-Seq for Cavendish banana ...
Xiuxiu Li (13880603)
core   +1 more source

Deciphering transcriptome complexity via long‐read sequencing

iMeta, EarlyView.
Long‐read sequencing is transforming transcriptomics from gene‐level quantification to isoform‐resolved interpretation by directly resolving full‐length transcript structures, transcription in repetitive regions, and linked molecular features. This review provides an end‐to‐end roadmap covering sequencing platforms, library preparation strategies ...
Chuwen Xu, Jia Li, Chenxi Yin, Keying Li, Tian Wang, Shiwen Gao, Yue Yu, Cheng Chang, Ye Wang, Guoqing Tong, Liang Gong, Wen Hu, Guoliang Chai, Yilai Han, Qian Qin, Suoqin Jin, Xiufen Zou, Bo Li, Tianyuan Zhang, Ana Conesa, Yunhao Wang, Dingjie Wang   +21 more
wiley   +1 more source

SERPINE1 Alternative Polyadenylation Influences Gastric Cancer Prognosis via N6‐Methyladenosine Modification

Cancer Science, EarlyView.
Multi‐omics integration of the transcriptomic APA landscape and m6A modifications identifies key prognostic genes. Their biological functions and molecular mechanisms in promoting tumor progression are comprehensively validated through in vitro assays. ABSTRACT Alternative polyadenylation (APA) and N6‐methyladenosine (m6A) methylation are critical post‐
Zhuoyi Wu, Ruyun Xu, Ju Fang, Bing Liu, Cao Zhang, Shangxin Zhang, Jing Ni   +6 more
wiley   +1 more source

iakerman/SNS-seq: SNS-seq analysis pipeline

, 2023
SNS-seq analysis pipeline - please note that depending on your reads, some parameters might need changing. This is published in Akerman et al, Nature Communications, 2020.
Akerman Lab
core   +1 more source