Results 61 to 70 of about 123,166 (168)

Characterization of Enterovirus Associated m6A RNA Methylation in Children With Neurological Symptoms: A Prospective Cohort Study

Frontiers in Neuroscience, 2021
Little is known about the particular changes of N6-methyladenosine (m6A) RNA methylation in enterovirus (EV) infection among children with neurologic symptoms.
Danping Zhu, Yongling Song, Dandan Hu, Suyun Li, Guangming Liu, Peiqing Li, Sida Yang   +6 more
doaj   +1 more source

A comprehensive evaluation of alignment algorithms in the context of RNA-seq. [PDF]

, 2012
Transcriptome sequencing (RNA-Seq) overcomes limitations of previously used RNA quantification methods and provides one experimental framework for both high-throughput characterization and quantification of transcripts at the nucleotide level.
Friedel, Caroline C., Friedel Caroline C., Caroline C. Friedel (29226), Caroline C Friedel, Lindner, Robert, Lindner Robert, Robert Lindner (107994), Robert Lindner, Caroline C. Friedel   +8 more
core   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Comprehensive analysis of the transcriptome-wide m6A methylome in colorectal cancer by MeRIP sequencing

Epigenetics, 2021
Accumulating evidence has demonstrated that N6-methyladenosine (m6A) plays important roles in various cancers, making it essential to profile m6A modifications at a transcriptome-wide scale in colorectal cancer (CRC).
Zhen Zhang, Quan Wang, Mengmeng Zhang, Wei Zhang, Long Zhao, Changjiang Yang, Bo Wang, Kewei Jiang, Yingjiang Ye, Zhanlong Shen, Shan Wang   +10 more
doaj   +1 more source

bigwig files for meRIP Illumina sequencing

, 2020
meRIP-seq data aligned to hg19 and Ad5 virus. All samples are seperated by coverage going to the forward and reverse strand.RNA-seq data is also aligned to hg19 and the Ad5 virus simultaneously. All bigwig show the raw coverage without any normalization.
Katharina Hayer (8393328)
core   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

N6-methyladenosine modification of THBS1 induced by affluent WTAP promotes Graves’ ophthalmopathy progression through glycolysis to affect Th17/Treg balance

Autoimmunity
Graves’ ophthalmopathy (GO) obvious manifestation is the imbalance of Th17/Treg. N6-methyladenosine (m6A) methylation is an important regulator of Th17/Treg balance.
Lin-na Li, Jie-man Wu, Zong-ji Zheng, Shu-xian Li, Meng-yi Cai, Meng-chen Zou   +5 more
doaj   +1 more source

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

Transcriptome-wide mapping of internal mRNA N 7-methylguanosine in sporulated and unsporulated oocysts of Eimeria tenella reveals stage-specific signatures

Parasites & Vectors
Background Growing evidence indicates that N 7-methylguanosine (m7G) modification plays critical roles in epigenetic regulation. However, no data regarding m7G modification are currently available in Eimeria tenella, a highly virulent species causing ...
Qing-Xin Fan, Zi-Rui Wang, Jin-Long Wang, Yu-Xuan Wang, Ze-Dong Zhang, Lin-Mei Yu, Tao Jia, Xing-Quan Zhu, Qing Liu   +8 more
doaj   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source