Results 41 to 50 of about 123,166 (168)

Unveiling m7G modification patterns and causal drivers governing intracranial aneurysm rupture risk through multi-omics validation and m7G-MeRIP-seq profiling. [PDF]

J Cereb Blood Flow Metab
Intracranial aneurysm (IA) rupture causes severe brain hemorrhage with high mortality, yet its molecular drivers remain unclear and better risk prediction is urgently needed. Using transcriptomics, single-cell analysis, and genetic data, we investigated the role of N7-methylguanosine (m7G) RNA modification in IA. We identified distinct m7G modification
Wu P, Maimaiti A, Ma Z, Abulizi A, Yang W, Yin S, Wang Y, Wang Z.   +7 more
europepmc   +3 more sources

Conjoint analysis of MeRIP-seq and RNA-seq

, 2022
The correlation analysis was designed to find overlaps between m6A difference genes identified by MeRIP-seq and the expression difference genes identified by RNA ...
Ye Zhao (11948567)
core   +1 more source

Transcriptome-wide analysis of glioma stem cell specific m6A modifications in long-non-coding RNAs

Scientific Reports, 2022
The interest in chemical RNA modifications is rapidly growing in the field of molecular biology. Dynamic and reversible alterations of N6-methyladenosine (m6A) RNA modification are responsible for a platter of structural and functional changes in healthy
Giedrius Steponaitis, Rytis Stakaitis, Indre Valiulyte, Raulas Krusnauskas, Rugile Dragunaite, Rūta Urbanavičiūtė, Arimantas Tamasauskas, Daina Skiriute   +7 more
doaj   +1 more source

Fear Stress During Pregnancy Affects Placental m6A-Modifying Enzyme Expression and Epigenetic Modification Levels

Frontiers in Genetics, 2022
As the hub connecting mother and offspring, the placenta’s normal development is vital for fetal growth. Fear stress can cause some structural alterations in the placenta and affect placental development and function. N6-methyladenosine (m6A) is the most
Qiyang Wang, Mingmin Pan, Tong Zhang, Yu Jiang, Peiyuan Zhao, Xihong Liu, Anqi Gao, Liping Yang, Junlin Hou   +8 more
doaj   +1 more source

Transcriptome-wide N6-methyladenosine methylation profile of atherosclerosis in mice

BMC Genomics, 2023
Background Atherosclerosis (AS) is a critical pathological event during the progression of cardiovascular diseases. It exhibits fibrofatty lesions on the arterial wall and lacks effective treatment.
Xinbin Zheng, Bo Zhou, Yuzhen Li, Hengren Zhong, Zhengxin Huang, Minhua Gu   +5 more
doaj   +1 more source

Comprehensive analysis of RNA m6A methylation in pressure overload-induced cardiac hypertrophy

BMC Genomics, 2022
Aim To analyze and compare the mRNA N6-methyladenosine modifications in transverse aortic constriction induced mice hearts and normal mice hearts. Materials and methods Colorimetric quantification was used to probe the changes in m6A modifications in the
Weidong Li, Chenxv Xing, Limeng Bao, Shengna Han, Tianxia Luo, Zhiju Wang, Hongkun Fan   +6 more
doaj   +1 more source

Integrative analysis implicates the significance of m6A in the liver fibrosis of biliary atresia by regulating THY1

Hepatology Communications, 2023
Whether N6-methyladenosine (m6A) is involved in biliary atresia (BA) remains undefined. Herein, we comprehensively evaluated the m6A profile in BA. When compared with normal controls, BA had an elevated m6A level with upregulated m6A writers.
Junfeng Wang, Min Du, Lingdu Meng, Yifan Yang, Shiwei He, Ye Zhu, Xue Ren, Meng Wei, Rui Dong, Shan Zheng, Gong Chen   +10 more
doaj   +1 more source

The alteration of N6-methyladenosine (m6A) modification at the transcriptome-wide level in response of heat stress in bovine mammary epithelial cells

BMC Genomics, 2022
Background Heat stress has a substantial negative economic impact on the dairy industry. N6-methyladenosine (m6A) is the most common internal RNA modification in eukaryotes and plays a key role in regulating heat stress response in animals. In dairy cows,
Ying Qi, Yiming Zhang, Jing Zhang, Jing Wang, Qiuling Li   +4 more
doaj   +1 more source

FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner

Journal of Experimental & Clinical Cancer Research, 2022
Background N6-methyladenosine (m6A) modification is the most common chemical modification in mammalian mRNAs, and it plays important roles by regulating several cellular processes.
Jiapeng Huang, Wei Sun, Zhihong Wang, Chengzhou Lv, Ting Zhang, Dalin Zhang, Wenwu Dong, Liang Shao, Liang He, Xiaoyu Ji, Ping Zhang, Hao Zhang   +11 more
doaj   +1 more source

DataSheet1_Validated Impacts of N6-Methyladenosine Methylated mRNAs on Apoptosis and Angiogenesis in Myocardial Infarction Based on MeRIP-Seq Analysis.docx

, 2022
Objectives: N6-methyladenosine (m6A) is hypothesized to play a role in the regulation of pathogenesis of myocardial infarction (MI). This study was designed to compare m6A-tagged transcript profiles to identify mRNA-specific changes on pathophysiological
Meiling Teng (11529268), Xiao Lu (355468), Yu Zheng (2950), Yini Dang (654078), Jiayue Wang (3136224), Yihui Cheng (5189663), Yingjie Zhang (381556), Zihao Kong (12011810), Xiu Zhang (1804195), Shenrui Wang (11529271), Wenjie Hua (7848546), Min Zhang (111999)   +11 more
core   +1 more source