Results 21 to 30 of about 123,166 (168)

Refined RIP-seq protocol for epitranscriptome analysis with low input materials. [PDF]

PLoS Biology, 2018
N6-Methyladenosine (m6A) accounts for approximately 0.2% to 0.6% of all adenosine in mammalian mRNA, representing the most abundant internal mRNA modifications.
Yong Zeng, Shiyan Wang, Shanshan Gao, Fraser Soares, Musadeqque Ahmed, Haiyang Guo, Miranda Wang, Junjie Tony Hua, Jiansheng Guan, Michael F Moran, Ming Sound Tsao, Housheng Hansen He   +11 more
doaj   +2 more sources

Epigenetic Effects and Potential Contributions of m⁶A Modification to Mammary Gland Development and Lactation of Dairy Goats Explored via MeRIP-seq. [PDF]

Animals (Basel)
To date, more than 170 chemical modifications have been identified in RNA. m6A (N6-methyladenine) RNA methylation is the most abundant form of mRNA modification in eukaryotes, playing an important role in RNA post-transcriptional processes. To investigate the function of m6A methylation modification in the development and lactation of dairy goat ...
Zhang L, Ji Z, Zhao M, Fu J, Meng X.
europepmc   +4 more sources

Additional file 1 of MoAIMS: efficient software for detection of enriched regions of MeRIP-Seq

, 2020
Additional file 1 Supplementary materials for "MoAIMS: efficient software for detection of enriched regions of MeRIP-Seq".
Zhang, Yiqian, Hamada, Michiaki
openaire   +2 more sources

Deep learning model and omics screening highlight angiotensinogen as a 5-methylcytosine (m5C) regulated mediator of tumor-microenvironment communication in liver cancer [PDF]

Frontiers in Immunology
IntroductionThe tumor microenvironment (TME) is critical for liver cancer progression and therapy response. As a key RNA modification, 5-methylcytosine (m5C) methylation is implicated in this process, yet the molecular mechanisms by which m5C ...
Huai Pang, Huai Pang, Huai Pang, Linshu Wang, Yang Li, Yuan Zhou, Yuan Zhou   +6 more
doaj   +2 more sources

MOESM1 of RADAR: differential analysis of MeRIP-seq data with a random effect model

, 2019
Additional file 1: Figure S1. Scatter plot of read count. Figure S2. Read count distribution of INPUT data. Figure S3. Sequencing depth distribution of m6A-seq in published literatures. Figure S4. Variability distribution comparing RNA-seq and m6A-seq (MeRIP-seq). Figure S5. Evaluating performances of benchmarked methods on simulated data using sliding
Zhang, Zijie, Zhan, Qi, Eckert, Mark, Zhu, Allen, Chryplewicz, Agnieszka, De Jesus, Dario, Ren, Decheng, Kulkarni, Rohit, Lengyel, Ernst, He, Chuan, Chen, Mengjie   +10 more
openaire   +2 more sources

Additional file 3 of Mapping the m1A, m5C, m6A and m7G methylation atlas in zebrafish brain under hypoxic conditions by MeRIP-seq

, 2022
Additional file 3. Supplemental Figure 1. Distribution of differential methylation peaks of m1A, m5C, m6A and m7G in the transcriptome. . The fold enrichment of transcript methylation modification peaks analyzed by MACS2 software is displayed in 5 quantiles (boxplot), and the bottom of the box plot shows the number of methylation modification peaks in ...
Li, Wei, Li, Xiaoyu, Ma, Xunjie, Xiao, Wei, Zhang, Jingjing   +4 more
openaire   +2 more sources

Profiles and roles of N6-methyladenosine modification in bovine oocyte maturation [PDF]

BMC Genomics
Background Bovine oocyte quality is crucial for successful in vitro embryo production; therefore, elucidating the mechanisms underlying oocyte maturation is essential.
Tiancang Han, Zhichao Wang, Xinqi Gan, Zhiyuan Yang, Wenzhuo Wang, Kunlong Hu, Ruiqing Zhu, Yunsheng Li, Yunhai Zhang, Zubing Cao   +9 more
doaj   +2 more sources

Dynamic m⁶A methylation during bovine preadipocyte differentiation and functional implication of the m⁶A writer METTL14 [PDF]

BMC Genomics
As a fundamental mechanism of post-transcriptional epigenetic regulation, RNA modifications have attracted increasing research interest in recent years.
Dianqi Zhang, Jiawei Du, Ni Gao, Hehan Qiu, Huaxuan Li, Chugang Mei, Linsen Zan   +6 more
doaj   +2 more sources

A comprehensive analysis of differential RNA m6A methylation modifications across the entire transcriptome in PTSD through high-throughput MeRIP sequencing

Brain Research Bulletin
In recent years, the increasing frequency of traumatic events has drawn greater attention to post-traumatic stress disorder (PTSD). However, its underlying biological mechanisms remain poorly understood.
Guiqing Zhang
exaly   +3 more sources

Mapping the m1A, m5C, m6A and m7G methylation atlas in zebrafish brain under hypoxic conditions by MeRIP-seq. [PDF]

BMC Genomics, 2022
Abstract Background The epigenetic modifications play important regulatory roles in tissue development, maintenance of physiological functions and pathological process. RNA methylations, including newly identified m1A, m5C, m6A and m7G, are important epigenetic modifications.
Li W, Li X, Ma X, Xiao W, Zhang J.
europepmc   +5 more sources