Results 21 to 30 of about 152,412 (174)

Mapping the m1A, m5C, m6A and m7G methylation atlas in zebrafish brain under hypoxic conditions by MeRIP-seq. [PDF]

BMC Genomics, 2022
Abstract Background The epigenetic modifications play important regulatory roles in tissue development, maintenance of physiological functions and pathological process. RNA methylations, including newly identified m1A, m5C, m6A and m7G, are important epigenetic modifications.
Li W, Li X, Ma X, Xiao W, Zhang J.
europepmc   +5 more sources

A low-cost, low-input method establishment for m6A MeRIP-seq. [PDF]

Biosci Rep
Abstract N6-methyladenosine (m6A) is a highly prevalent modification found in mammal mRNA molecules that plays a crucial role in the regulation of cellular function. m6A RNA immunoprecipitation sequencing (MeRIP-seq) has been frequently used in transcriptomics research to identify the location of m6A.
Xia W, Guo L, Su H, Li J, Lu J, Li H, Huang B.   +6 more
europepmc   +3 more sources

Comprehensive Analysis of Differentially Expressed Profiles of mRNA N6-Methyladenosine in Colorectal Cancer

Frontiers in Cell and Developmental Biology, 2022
Aim: To comprehensively profile the landscape of the mRNA N6-methyladenosine (m6A) modification in human colorectal cancer (CRC).Methods: Methylated RNA immunoprecipitation sequencing (MeRIP-seq) was explored to compare the difference in mRNA N6 ...
Na Li, Qin Guo, Qiao Zhang, Bai-Jun Chen, Xiao-An Li, Yan Zhou   +5 more
doaj   +1 more source

NSUN2-Mediated m⁵C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA. [PDF]

Adv Sci (Weinh)
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Zhu X, Liu X, Yu X, Han Q, Shi F, Song W, Liu L, Chu C, Shen C, Zhang Z, Li X.   +10 more
europepmc   +2 more sources

A Metabolic-Epigenetic Axis of AARS1/IGF2BP3-K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence. [PDF]

Adv Sci (Weinh)
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Jiang P, Zheng Y, Tian C, Tu Y, Chang X, Yu J, Yu H, Gong C, Xiong J, Baker PN, Fu Y, Tong C.   +11 more
europepmc   +2 more sources

Comprehensive analysis of transcriptome-wide m6A methylome in the lung tissues of mice with acute particulate matter exposure

Ecotoxicology and Environmental Safety, 2022
Particulate matter (PM) exposure is identified as a critical risk factor for chronic airway diseases, but the biological mechanism of PM-induced lung damage was not fully elucidated.
Juan Song, Yingying Zeng, Mengchan Zhu, Guiping Zhu, Cuicui Chen, Meiling Jin, Jian Wang, Yuanlin Song   +7 more
doaj   +1 more source

MeRIP-Seq initially revealed the role of m6A modification in Chinese sacbrood virus-infected <i>Apis cerana</i> larvae. [PDF]

Front Microbiol
Chinese sacbrood virus (CSBV) is highly lethal to honeybee larvae (especially the larva of Apis cerana) and causes considerable losses to beekeeping industry. N6-methyladenine (m6A) modification of mRNA is a predominant post-transcriptional modification in eukaryotes and plays a role in viral infection.
Liu Y, Bai H, Qiu H, Fei D, Ma M.
europepmc   +4 more sources

Role of N6-methyladenosine methylation in transverse aortic constriction-induced cardiac fibrosis: insights from MeRIP-seq analysis. [PDF]

Mol Biol Rep
Abstract This study aimed to investigate the role and potential mechanisms of N6-methyladenosine (m6A) methylation in a mouse model of transverse aortic constriction (TAC)-induced cardiac fibrosis using MeRIP-seq. A TAC-induced cardiac fibrosis mouse model was established, and cardiac function and structural parameters were assessed ...
Liu S, Liu H, Bai Q, Wei Z, Zhao P, Chen H, Song B, Yu C.   +7 more
europepmc   +4 more sources

REPIC: a database for exploring the N 6-methyladenosine methylome

Genome Biology, 2020
The REPIC (RNA E PItranscriptome Collection) database records about 10 million peaks called from publicly available m6A-seq and MeRIP-seq data using our unified pipeline. These data were collected from 672 samples of 49 studies, covering 61 cell lines or
Shun Liu, Allen Zhu, Chuan He, Mengjie Chen   +3 more
doaj   +1 more source

N6‐methyladenosine reader YTHDF3 regulates melanoma metastasis via its ‘executor' LOXL3

Clinical and Translational Medicine, 2022
Background A number of studies have demonstrated that N6‐methyladenosine (m6A) plays a vital role in the pathological process of various tumours. Recently, it was found that m6A writers or erasers affect the tumourigenesis of melanoma.
Hao‐ze Shi, Jing‐shu Xiong, Lu Gan, Ying Zhang, Cong‐cong Zhang, Ying‐qi Kong, Qiu‐ju Miao, Cui‐cui Tian, Rong Li, Jin‐quan Liu, Er‐jia Zhang, Wen‐bo Bu, Yan Wang, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +15 more
doaj   +1 more source