Results 111 to 120 of about 152,412 (174)

FTO Facilitates Cervical Cancer Malignancy Through Inducing m6A‐Demethylation of PIK3R3 mRNA

Cancer Medicine
Background The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6‐methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity‐associated gene (FTO) works as the m6A ...
Bingxin Chen, Liming Wang, Xiaomin Li, Ci Ren, Chun Gao, Wencheng Ding, Hui Wang   +6 more
doaj   +1 more source

RNA m6A-binding protein YTHDF2 regulates neoblast proliferation in planarian regeneration by targeting ASTACIN Signaling

Journal of Advanced Research
Introduction: Planarians exhibit remarkable notable regenerative capacity, through the self-renewal of the neoblast stem cells. The RNA N6-methyladenosine (m6A)-binding protein YTHDF2 recognizes m6A modified regions on the mRNA and facilitates their ...
Hanxue Zheng, Du Wang, Linfeng Li, Qian Xu, Mengdi Cheng, Jiayi Chen, Siyi Zhu, Duan Lin, Ruohan Lin, Wenjuan Xue, Shiyue Liu, Gerui Qu, Yuan Yu, Fulin Chen   +13 more
doaj   +1 more source

Dynamic m⁶A methylation during bovine preadipocyte differentiation and functional implication of the m⁶A writer METTL14

BMC Genomics
As a fundamental mechanism of post-transcriptional epigenetic regulation, RNA modifications have attracted increasing research interest in recent years.
Dianqi Zhang, Jiawei Du, Ni Gao, Hehan Qiu, Huaxuan Li, Chugang Mei, Linsen Zan   +6 more
doaj   +1 more source

Profiles and roles of N6-methyladenosine modification in bovine oocyte maturation

BMC Genomics
Background Bovine oocyte quality is crucial for successful in vitro embryo production; therefore, elucidating the mechanisms underlying oocyte maturation is essential.
Tiancang Han, Zhichao Wang, Xinqi Gan, Zhiyuan Yang, Wenzhuo Wang, Kunlong Hu, Ruiqing Zhu, Yunsheng Li, Yunhai Zhang, Zubing Cao   +9 more
doaj   +1 more source

Unveiling m7G modification patterns and causal drivers governing intracranial aneurysm rupture risk through multi-omics validation and m7G-MeRIP-seq profiling

Journal of Cerebral Blood Flow & Metabolism
Intracranial aneurysm (IA) rupture causes severe brain hemorrhage with high mortality, yet its molecular drivers remain unclear and better risk prediction is urgently needed. Using transcriptomics, single-cell analysis, and genetic data, we investigated the role of N7-methylguanosine (m7G) RNA modification in IA. We identified distinct m7G modification
Pengfei Wu, Aierpati Maimaiti, Zekun Ma, Alimasi Abulizi, Wenbo Yang, Shengnan Yin, Yongxin Wang, Zengliang Wang   +7 more
openaire   +2 more sources

METTL3-mediated m6A methylation to promote mandibular condyle fracture repair via TGF-β/Smad signaling pathway

Scientific Reports
Mandibular condylar fractures are common maxillofacial injuries. N6-methyladenosine (m6A), one of the most abundant eukaryotic mRNA modifications, has not yet been clearly elucidated in terms of its specific role in condylar fracture repair. A mandibular
Zhitao Yao, Guodong Lv, Wei An, Maimaitituxun, Jin Zhao   +4 more
doaj   +1 more source

ALKBH5 regulates chicken adipogenesis by mediating LCAT mRNA stability depending on m6A modification

BMC Genomics
Background Previous studies have demonstrated the role of N6-methyladenosine (m6A) RNA methylation in various biological processes, our research is the first to elucidate its specific impact on LCAT mRNA stability and adipogenesis in poultry. Results The
Xiaohuan Chao, Lijin Guo, Chutian Ye, Aijun Liu, Xiaomeng Wang, Mao Ye, Zhexia Fan, Kang Luan, Jiahao Chen, Chunlei Zhang, Manqing Liu, Bo Zhou, Xiquan Zhang, Zhenhui Li, Qingbin Luo   +14 more
doaj   +1 more source

Comprehensive Transcriptome-Wide Profiling of 5-Methylcytosine Modifications in Long Non-Coding RNAs in a Rat Model of Traumatic Brain Injury

Current Issues in Molecular Biology
Traumatic brain injury (TBI) poses a major global health challenge, leading to serious repercussions for those affected and imposing considerable financial strains on families and healthcare systems.
Zhijun Xiang, Yixing Luo, Jiangtao Yu, Haoli Ma, Yan Zhao   +4 more
doaj   +1 more source

Transcriptome-wide N6-methyladenosinem modifications analysis of chicken cecum in responding to Campylobacter jejuni inoculation

Frontiers in Immunology
IntroductionCampylobacter jejuni (C. jejuni), a commensal food-borne pathogen, poses severe threat to human health and poultry industry. N6-methyladenosine (m6A) mRNA modification is associated with innate immunity.
Yanan Zhao, Yuanmei Wang, Liying Liu, Yanru Ren, Long Liu, Jiayi Wang, Xianyao Li, Xianyao Li   +7 more
doaj   +1 more source

CODE_for_RNA-seq

, 2019
code for RNA-seq data ...
Xuanyu Liu (5556740)
core   +1 more source