Results 121 to 130 of about 4,546 (178)

The Oncogenic Role of UBXN1 in Gastric Cancer Is Attributed to the METTL16‐Mediated m6A Methylation and Histone Modifications

Cancer Medicine
Background Multiple epigenetic regulatory mechanisms are crucial in tumorigenesis and development. However, the synergistic relationship between N6‐methyladenosine (m6A) and histone modifications in regulating gene expression of gastric cancer (GC ...
Kesong Shi, Yani Chen, Tian Gao, Hua Guo, Xinyao Fu, Yuan Wu, Haiquan Yu   +6 more
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Ythdf2 Accelerates Lymphangiogenesis In Oscc Through Rnf43/Wnt5b Pathway

International Dental Journal
Aim or purpose: The aim of this study is to investigate the role of N6-methyladenosine (m6A), the most abundant intrinsic mRNA modification in eukaryotes, in lymphangiogenesis and lymphatic metastasis in oral squamous cell carcinoma (OSCC). Materials and
Tianjiao Li
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Comprehensive Transcriptome-Wide Profiling of 5-Methylcytosine Modifications in Long Non-Coding RNAs in a Rat Model of Traumatic Brain Injury

Current Issues in Molecular Biology
Traumatic brain injury (TBI) poses a major global health challenge, leading to serious repercussions for those affected and imposing considerable financial strains on families and healthcare systems.
Zhijun Xiang, Yixing Luo, Jiangtao Yu, Haoli Ma, Yan Zhao   +4 more
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METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus

BMC Medicine
Background Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown cause. N6-methyladenosine (m6A) is the most common mRNA modification and participates in various immune processes such as interferon production and immune cell regulation ...
Yu Liu, Xiaohua Wang, Mingcheng Huang, Ailing Luo, Shanshan Liu, Mansi Cai, Weinian Li, Shiwen Yuan, Zhihua Zheng, Xiaoping Liu, Chun Tang   +10 more
doaj   +1 more source

Transcriptome-wide N6-methyladenosinem modifications analysis of chicken cecum in responding to Campylobacter jejuni inoculation

Frontiers in Immunology
IntroductionCampylobacter jejuni (C. jejuni), a commensal food-borne pathogen, poses severe threat to human health and poultry industry. N6-methyladenosine (m6A) mRNA modification is associated with innate immunity.
Yanan Zhao, Yuanmei Wang, Liying Liu, Yanru Ren, Long Liu, Jiayi Wang, Xianyao Li, Xianyao Li   +7 more
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Comprehensive analysis of m6A methylated modification of fibrotic atria in rats induced by chronic intermittent hypoxia [PDF]

BackgroundAtrial fibrosis serves as a key pathological basis for atrial fibrillation, significantly elevating the risk of cardiovascular events. However, its molecular mechanisms remain incompletely understood. N⁶-methyladenosine (m6A) modifications have
Hao Zhang, Hualing Wang, Jiao Li, Lijun Wang, Pengyu Sun, Shiyu Qi, Siyu Guan, Tao Geng, Tianshu Gu, Weiding Wang, Wenfeng Shangguan, Xiaodong Xia, Xuan Cao, Xue Liang, Zhiqiang Zhao   +14 more
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METTL3-dependent m⁶A RNA methylation regulates transposable elements and represses human naïve pluripotency through transposable element-derived enhancers [PDF]

N 6-methyladenosine (m6A) is the most prevalent messenger RNA modification with diverse regulatory roles in mammalian cells. While its functions are well-documented in mouse embryonic stem cells (mESCs), its role in human pluripotent stem cells (hPSCs ...

core   +1 more source

Cross-lineage 5-methylcytosine methylome profiling reveals methylated divergence among Toxoplasma gondii tachyzoites of the three major clonal lineages [PDF]

Background Toxoplasma gondii is a globally widespread zoonotic parasite, infecting nearly one-third of the human population, often leading to chronic, latent infections.
Elsheikha, Hany M, Liu, Qing, Song, Hong-Yu, Tian, Chen-Ran, Tian, Xing, Zheng, Wen-Bin, Zheng, Xiao-Nan, Zhu, Xing-Quan   +7 more
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Characterization of N6-methyladenosine long non-coding RNAs in sporadic congenital cataract and age-related cataract [PDF]

AIM: To characterize the N6-methyladenosine (m6A) modification patterns in long non-coding RNAs (lncRNAs) in sporadic congenital cataract (CC) and age-related cataract (ARC).
Ce Zheng, Hong-Fei Ye, Huang Zhu, Ji-Li Chen, Jiao Lyu, Pei-Quan Zhao, Ping Fei, Xiang Zhang, Xun-Xiang Guo, Yu Xu, Zhen-Nan Zhao   +10 more
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Profiling of RNA N6-Methyladenosine methylation reveals the critical role of m6A in betaine alleviating hepatic steatosis

Scientific Reports
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major predisposing factor of metabolic dysfunction-associated steatohepatitis, hepatic fibrosis and hepatocellular carcinoma.
Yuna Wu, Jingsu Yu, Haisen Song, Dehao Lu, Zhilin Li, Xiangling Li, Zhaoxuan Ding, Lei Zhou, Jie Ma, Ying Zhang, Yixing Li   +10 more
doaj   +1 more source