Results 131 to 140 of about 4,546 (178)

Base-Resolution Sequencing Methods for Whole-Transcriptome Quantification of mRNA Modifications [PDF]

RNA molecules are not merely a combination of four bases of A, C, G, and U. Chemical modifications occur in almost all RNA species and play diverse roles in gene expression regulation. The abundant cellular RNAs, such as ribosomal RNA (rRNA) and transfer
Dai, Qing, He, Chuan, Zhang, Li-Sheng
core   +1 more source

Hypoxic BMSCs accelerate femur fracture healing via the METTL3/SLC2A3 m6A-glycolysis axis

Journal of Translational Medicine
Background Hypoxia promotes the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), thereby accelerating fracture healing. However, the underlying molecular mechanisms remain unclear.
Shaohai Lin, Jia Wu, Lijun Deng, Yudan Long, Wenbo Xu, Wenxu Nie , Guanghui Liu, Yajun Han, Min Zeng, Zhangyuan Lin, Yong Zhu, Haitao Long   +11 more
doaj   +1 more source

METTL3 facilitates the progression of cervical cancer by m6A modification-mediated up-regulation of NEK2

Scientific Reports
N6-methyladenosine (m6A) is the most prevalent modification found in eukaryotic RNA and played a significant role in various cancers. However, the mechanism by which m6A modification influences cervical cancer (CC) tumorigenesis remains unclear ...
Yilin Guo, Yangyang Bai, Lu Wang, Zhen Xu, Nan Zhang, Wuliang Wang, Hu Zhao   +6 more
doaj   +1 more source

Mechanisms of DNA hypomethylating agents in acute myeloid leukemia [PDF]

Aberrant DNA methylation is a hallmark of many cancers. As such, there has been substantial interest in the development of anti-cancer strategies which modulate epigenetic programs associated with alterations in DNA methylation. In acute myeloid leukemia
Dai, Raymond
core  

YTHDF2 promotes anaplastic thyroid cancer progression by activating the DDIT4/AKT/mTOR signaling pathway

Biology Direct
Background RNA methylation, an important reversible post-transcriptional modification in eukaryotes, has emerged as a prevalent epigenetic alteration. However, the role of the m6A reader YTH domain family 2 (YTHDF2) has not been reported in anaplastic ...
Bao Dai, Lei Xu, Shikuo Rong, Muye Song, Ziteng Lan, Weijian Chen, Lingyun Zhang, Yongchen Liu, Linhe Wang, Jinghua Li, Jian Chen, Zeyu Wu   +11 more
doaj   +1 more source

N6-Methyladenosine Promotes TNF mRNA Degradation In CD4+ T Lymphocytes [PDF]

N6-methyladenosine (m6A) is a RNA modification that can regulate post-transcriptional processes including RNA stability, translation, splicing, and nuclear export.
Calis, Jorg J A, Coffer, Paul J, Evers, Anouk, Kievit, Corlinda R E, Lebbink, Robert J, Mocholi, Enric, Mokry, Michal, Picavet, Lucas W, Scholman, Rianne C, Sijbers, Lyanne J P M, van den Dungen, Noortje A M, van Loosdregt, Jorg, van Vroonhoven, Ellen C N, Vastert, Sebastiaan J   +13 more
core  

m6A modification of mutant huntingtin RNA promotes the biogenesis of pathogenic huntingtin transcripts [PDF]

In Huntington’s disease (HD), aberrant processing of huntingtin (HTT) mRNA produces HTT1a transcripts that encode the pathogenic HTT exon 1 protein. The mechanisms behind HTT1a production are not fully understood.
Bates, Gillian P, Brito, Veronica, del Toro, Daniel, Essmann, Amelie, Gines, Silvia, Marti, Eulalia, Mouro Pinto, Ricardo, Pupak, Anika, Rodriguez-Navarro, Irene, Sathasivam, Kirupa, Singh, Ankita, Vang orom, Ulf Andersson   +11 more
core  

Unveiling m7G modification patterns and causal drivers governing intracranial aneurysm rupture risk through multi-omics validation and m7G-MeRIP-seq profiling. [PDF]

J Cereb Blood Flow Metab
Wu P, Maimaiti A, Ma Z, Abulizi A, Yang W, Yin S, Wang Y, Wang Z.   +7 more
europepmc   +1 more source

L-MYC expression maintains self-renewal and prolongs multipotency of primary human neural stem cells [PDF]

, 2016
Benetatos, Joseph, Brody, David L, et al,, Rong, Xianfang   +3 more
core   +1 more source

Weakly supervised learning of RNA modifications from low-resolution epitranscriptome data [PDF]

, 2021
Coenen, Frans, Huang, Daiyun, Meng, Jia, Song, Bowen, Su, Jionglong, Wei, Jingjue   +5 more
core   +1 more source