Results 71 to 80 of about 19,807 (208)
The Anatomical Record, EarlyView.Abstract Meissner corpuscles are rapidly adapting mechanoreceptors involved in tactile discrimination in human glabrous hand skin. Detailed information on their regional distribution and variation across age, sex, and hand side remains limited. This study mapped Meissner corpuscles in 17 phalangeal and palmar regions from 46 individuals (27 male and 19
Irene Amigo +7 more
wiley +1 more source
Merkel Cell Carcinoma With Divergent Differentiation-Or Something Else? A Triphasic Cutaneous Carcinoma With Lineage Plasticity. [PDF]
J Cutan PatholABSTRACT Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma that typically arises in sun‐exposed skin of older or immunosuppressed patients. Combined or collision tumors involving MCC and other cutaneous malignancies are uncommon, and tumors exhibiting more than two distinct malignant phenotypes are exceptionally rare.
Khalil Z, Elameen H, Alomari AK.
europepmc +2 more sources
Arthritis &Rheumatology, EarlyView.Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source
Tumor virus–induced lineage survival circuit drives Merkel cell carcinogenesis
The Journal of Clinical InvestigationApproximately 80% of Merkel cell carcinoma (MCC) cases are caused by Merkel cell polyomavirus (MCV), driven by its T antigen oncogene. Why MCV drives MCC, a skin cancer that displays the neuroendocrine Merkel cell phenotype, remains unclear.
Masahiro Shuda
doaj +1 more source
Journal of the American Academy of DermatologyMerkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that is highly radiosensitive and immunogenic. Immunotherapy is the primary treatment of advanced disease, and immune checkpoint inhibitors show promise as neoadjuvant or adjuvant therapy in patients with high-risk resectable MCC.
Sach Thakker +5 more
+8 more sources
Regulatory harmonization: Evolution, globalization and future directions
British Journal of Clinical Pharmacology, EarlyView.Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm +2 more
wiley +1 more source
Merkel cell carcinoma with seborrheic keratosis: A unique association
Indian Journal of Pathology and Microbiology, 2018 Merkel cell carcinoma (MCC) is a rare, clinically aggressive neuroendocrine carcinoma of the skin; MCC is 40 times less common as compared to melanoma. The most frequently reported sites have been the head and neck, extremities, and trunk.
Murthy S Anand +3 more
doaj +1 more source
The Cutaneous Branch of the Obturator Nerve: Common Finding or a Rarity Worthy of Note
Clinical Anatomy, EarlyView.ABSTRACT According to textbook descriptions, branches of the femoral and obturator nerves provide the sensory innervation to the medial side of the thigh. However, as the exact prevalence of the obturator nerve's cutaneous branch is unknown, an anatomic study was conducted to reveal its role in providing cutaneous innervation to the medial thigh ...
Christoph Fuchssteiner +3 more
wiley +1 more source
Artificial structures for human‐machine interfaces with closed‐loop interaction
FlexMat, EarlyView.Artificial structures bridge sensing and feedback in closed‐loop human‐machine interfaces by providing geometry‐enabled mechanical and functional programmability. This review maps the role of artificial structures in diverse sensing modalities and feedback strategies, and illustrates their integration into closed‐loop interaction systems, highlighting ...
Taiqi Hu +4 more
wiley +1 more source
Head &Neck, EarlyView.ABSTRACT Background H&N Merkel cell carcinoma (MCC) mainly affects elderly patients, yet age‐stratified treatment patterns and outcomes data are scarce. Methods We analyzed 88 consecutive H&N MCC patients (2000–2022) by age (< 75 vs. ≥ 75 years). OS was estimated by Kaplan–Meier analysis and MCC‐specific death with competing‐risks methods (cause ...
Igor Vainer +3 more
wiley +1 more source