Results 51 to 60 of about 63,064 (231)

Survival outcomes and epidemiology of Merkel cell carcinoma of the lower limb and hip: A Surveillance, Epidemiology, and End Results analysis 2000-2018Capsule Summary

JAAD International, 2022
Background: Merkel cell carcinoma of lower limb and hip skin is a rare skin tumor that has a high recurrence rate. Objective: To assess epidemiology and survival outcomes of the lower limb and hip Merkel cell carcinoma, which are less addressed in the ...
Matteo Scampa, MS, Rastine Merat, MD, PhD, Evangelia Tzika, MD, Daniel F. Kalbermatten, MD, PhD, Carlo M. Oranges, MD, PhD   +4 more
doaj   +1 more source

Remembering the forgotten child: the role of immune checkpoint inhibition in patients with human immunod eficiency virus and cancer. [PDF]

, 2019
Patients with human immunodeficiency virus (HIV) infection have a high risk of developing virally-mediated cancers. These tumors have several features that could make them vulnerable to immune checkpoint inhibitors (ICIs) including, but not limited to ...
Adashek, Jacob J, Galanina, Natalie, Junior, Pedro Nazareth Aguiar, Kurzrock, Razelle   +3 more
core  

Signature of a non-harmonic potential as revealed from a consistent shape and fluctuation analysis of an adherent membrane [PDF]

, 2014
The interaction of fluid membranes with a scaffold, which can be a planar surface or a more complex structure, is intrinsic to a number of systems - from artificial supported bilayers and vesicles to cellular membranes.
Bihr, Timo, Merkel, Rudolf, Monzel, Cornelia, Schmidt, Daniel, Seifert, Udo, Sengupta, Kheya, Smith, Ana-Sunčana   +6 more
core   +6 more sources

In Situ Photopolymerization of Smectic B Liquid‐Crystalline Electrolytes from Mesogenic Phosphate–Diacrylate/Ionic Liquid Complexes for High‐Performance Soft Ionic Actuators

Advanced Robotics Research, EarlyView.
A flexible liquid‐crystalline electrolyte membrane via in situ photopolymerization of a phosphate‐functionalized mesogen, ionic liquid, and diacrylate monomer is developed. The resulting smectic B (SmB)‐phase structure enables 2D ion transport with high conductivity (10−4 S cm−1).
Chengyang Liu, Masafumi Yoshio
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Response of Merkel cell polyomavirus-positive Merkel cell carcinoma xenografts to a survivin inhibitor [PDF]

, 2013
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with high mortality. Merkel cell polyomavirus (MCV), discovered in 2008, is associated with ∼80% of MCC.
A Guastafierro, A Kita, Anna Guastafierro, AW Tolcher, B Kumar, BD Cheson, D Schrama, D Schrama, Daniel Normolle, EA Engels, F Lamers, G Giaccone, H Ahrens, H Feng, H Xie, I Prieto Muñoz, J Albores-Saavedra, J Cheng, J Kaae, J Li, K Yamanaka, KD Lewis, L Zhao, LD Shultz, Lindsay R. Dresang, M Agelli, M Heath, M Plummer, M Shuda, M Shuda, M Shuda, M Van Gele, M Veness, N Nakamura, NC Hodgson, Patrick S. Moore, PJ Allen, PW Harms, R Arora, R Houben, R Houben, Reety Arora, S Kuwamoto, Shou-Jiang Gao, ST Rosen, T Iwasa, T Nakahara, T Nakahara, T Nakahara, T Nakamura, T Satoh, T Yamauchi, TY Eng, Y Aoyama, Y Chang, Yuan Chang   +55 more
core   +3 more sources

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Inhibitory Immune Checkpoints beyond Programmed Cell Death Ligand 1 in Merkel Cell Carcinoma: Abundant Expression of TIGIT Independent of the Presence of Merkel Cell Polyoma Virus

Acta Dermato-Venereologica
Merkel cell carcinoma is a rare, aggressive skin cancer in which Merkel cell polyoma virus (MCPyV) is frequently pathogenically involved. After failure of anti-programmed cell death protein 1/programmed cell death ligand 1 immunotherapy, therapeutic ...
Ferdinand Toberer, Julia K. Winkler, Leroy Atienza Fernandez, Lea Adams, Alexander Brobeil, Marcell Tóth, Alexander H. Enk, Jürgen C. Becker, Anke Lonsdorf   +8 more
doaj   +1 more source

Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells.

PLoS ONE, 2008
Merkel cell-neurite complexes are highly sensitive touch receptors comprising epidermal Merkel cells and sensory afferents. Based on morphological and molecular studies, Merkel cells are proposed to be mechanosensory cells that signal afferents via ...
Henry Haeberle, Leigh A Bryan, Tegy J Vadakkan, Mary E Dickinson, Ellen A Lumpkin   +4 more
doaj   +1 more source

From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis

Frontiers in Microbiology, 2021
Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC).
Nathan A. Krump, Jianxin You
doaj   +1 more source