Results 31 to 40 of about 19,807 (208)

Merkel Cell Polyomavirus Strains in Patients with Merkel Cell Carcinoma

Emerging Infectious Diseases, 2009
الملخص لقد تحققنا مما إذا كان مرضى سرطان خلايا ميركل (MCC) في فرنسا يحملون فيروس الورم المتعدد لخلايا ميركل (MCPyV) ثم حددنا اختلافات السلالة. جميع عينات MCC المجمدة و 45 ٪ من العينات المثبتة بالفورمالين والبارافين، ولكن لم يكن لدى أي من عينات سرطان الغدد الصماء العصبية غير MCC MCPyV. كانت السلالات من فرنسا والولايات المتحدة متشابهة.
Antoine Touzé, Julien Gaitan, Annabel Maruani, E. Le Bidre, Angélique Doussinaud, Christine Clavel, A. Durlach, F. Aubin, Serge Guyétant, G. Lorette, Pierre Coursaget   +10 more
openaire   +4 more sources

Histological, Immunohistological, and Clinical Features of Merkel Cell Carcinoma in Correlation to Merkel Cell Polyomavirus Status

Journal of Skin Cancer, 2012
Merkel cell carcinoma is a rare, but highly malignant tumor of the skin with high rates of metastasis and poor survival. Its incidence rate rises and is currently about 0.6/100000/year.
T. Jaeger, J. Ring, C. Andres
doaj   +1 more source

Pathophysiology of merkel cell

Journal of Oral and Maxillofacial Pathology, 2013
The objective of this review is to introduce Merkel cells (MCs), to provide a basic overview on the theoretical background of function, development and clinical importance of MCs. The origin of human MCs have been controversial. Some investigators believe that it is a neural crest derivate, whereas others have proposed that it is a differentiation ...
Munde, Prashant Balasaheb, Khandekar, Shubhangi P, Dive, Alka M, Sharma, Aparna   +3 more
openaire   +3 more sources

Merkel cell carcinoma

Tidsskrift for Den norske legeforening, 2022
Merkel cell carcinoma is an uncommon but aggressive tumour with a high metastatic potential. A rapidly growing, non-tender cutaneous tumour on sun-exposed areas of the body in older patients should raise suspicion of the condition. It may be necessary to combine the patient history with clinical, radiological and pathological findings in order to make ...
Morten Kristoffer, Nyrud, Åse, Bratland, Linn, Landrø, Trine, Brevig, Truls, Ryder, Robert, Hermann, Lars, Frich   +6 more
openaire   +2 more sources

A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.

PLoS Genetics, 2016
The Sonic hedgehog (Shh) signaling pathway regulates developmental, homeostatic, and repair processes throughout the body. In the skin, touch domes develop in tandem with primary hair follicles and contain sensory Merkel cells.
Ying Xiao, Ying Xiao, Daniel T Thoresen, Lingling Miao, Jonathan S Williams, Chaochen Wang, Radhika P Atit, Sunny Y Wong, Isaac Brownell   +8 more
doaj   +1 more source

Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms

Advanced Functional Materials, EarlyView.
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger, Min Jiang, Florian Belger, Fabian Link, Benjamin Winkeljann, Olivia M. Merkel   +5 more
wiley   +1 more source

Identification of Merkel cells associated with neurons in engineered skin substitutes after grafting to full thickness wounds.

PLoS ONE, 2019
Engineered skin substitutes (ESS), prepared using primary human fibroblasts and keratinocytes with a biopolymer scaffold, were shown to provide stable closure of excised burns, but relatively little is known about innervation of ESS after grafting.
Jennifer M Hahn, Kelly A Combs, Christopher M Lloyd, Kevin L McFarland, Steven T Boyce, Dorothy M Supp   +5 more
doaj   +1 more source

Merkel cell carcinoma arising from postoperative scar: An unusual presentation

Turkderm Turkish Archives of Dermatology and Venereology, 2021
Merkel cell carcinoma (MCC) is an aggressive and uncommon primary cutaneous neuroendocrine cancer. With unknown pathogenesis, immunosuppression, ultraviolet radiation, Merkel cell polyomavirus, and arsenic exposure are the risk factors.
Mualla Polat, Tekden Karapınar, Hesna Müzeyyen Astarcı, Bengü Tuman, Metin Görgü   +4 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Complete Pathway Refactoring and Combinatorial Biosynthesis of Anthracyclines for Modulation of Histone Eviction and DNA Damage Bioactivities

Angewandte Chemie, EarlyView.
A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang, Heli Tirkkonen, Sabina Y. van der Zanden, Larissa Ponomareva, Isaline Fagon, Leslie Fève, Kendall Paige, Courtney L. Brown, Nora Schwartz, Jacob Hecht, Jennifer Nguyen, Jon S. Thorson, Jacques Neefjes, S. Eric Nybo, Khaled A. Shaaban, Mikko Metsä‐Ketelä   +15 more
wiley   +2 more sources