Results 91 to 100 of about 3,967 (153)

Estimating Renal Function in Drug Development: Time to Take the Fork in the Road [PDF]

, 2019
Renal function is the most commonly applied patient‐specific quantitative variable used to determine drug doses. Measurement of renal function is not practical in most clinical settings; therefore, clinicians often rely on estimates when making dosing ...
Accetta, Beker, Benet, Bohula, Bouquegneau, Cockcroft, Delanaye, Eastwood, Gagneux-Brunon, Hoover, Hornum, Inker, Kaye, Kingsley, Levey, Levey, Levey, Levey, Lim, Luke, Matzke, Merdjan, O'Riordan, O'Riordan, Pai, Park, Park, Peck, Pottel, Rubino, Schwartz, Stevens, Stevens, Teo, Yeung   +34 more
core   +1 more source

New Antibiotics Against Multidrug-Resistant Gram-Negative Bacteria in Lung Transplantation: Clinical Evidence, Safety, and PK/PD Properties

Transplant International
Infections caused by multidrug-resistant Gram-negative bacteria (MDR-GNB) and Pseudomonas aeruginosa are leading causes of morbidity and mortality after lung transplantation (LuTx).
Andrea Lombardi, Andrea Lombardi, Davide Mangioni, Giulia Viero, Laura Alagna, Giulia Renisi, Paola Saltini, Alessandra Bandera, Alessandra Bandera   +8 more
doaj   +1 more source

A Difficult Case of Ventriculitis in a 40-Year-Old Woman with Acute Myeloid Leukemia [PDF]

Ventriculitis and nosocomial meningitis caused by carbapenem-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria represent a growing treatment challenge.
Cascio, Antonio, Giammanco, Giovanni Maurizio, Iacopino, Domenico Gerardo, Maugeri, Rosario, Pipitò, Luca, Rubino, Raffaella, Santoro, Marco, Siragusa, Sergio, Sucato, Giuseppe, Trizzino, Marcello   +9 more
core   +1 more source

Activity of β-Lactamase Inhibitor Combinations Against Enterobacterales Isolated from Patients with Intra-Abdominal Infection from United States Medical Centres (2019–2023)

Antibiotics
Objective: To evaluate the antimicrobial susceptibility of Enterobacterales isolated from patients with intra-abdominal infections (IAI) in United States (US) medical centres.
Helio S. Sader, John H. Kimbrough, Marisa L. Winkler, Rodrigo E. Mendes, Mariana Castanheira   +4 more
doaj   +1 more source

Activity of aztreonam-avibactam and ceftazidime-avibactam against β-lactamase-producing enterobacterales Isolates from United States hospitals

Journal of Global Antimicrobial Resistance
Objectives: Enterobacterales isolates producing β-lactamases are widespread and threaten the use of β-lactams. This study evaluated the activity of aztreonam-avibactam and comparator antimicrobial agents against Enterobacterales isolates producing common
Lalitagauri M Deshpande, Timothy B Doyle, Helio S Sader, Mariana Castanheira   +3 more
doaj   +1 more source

Aztreonam Combinations with Avibactam, Relebactam, and Vaborbactam as Treatment for New Delhi Metallo-β-Lactamase-Producing Enterobacterales Infections—In Vitro Susceptibility Testing

Pharmaceuticals
Antimicrobial resistance is a major global health issue. Metallo-β-lactamases (MBL), in particular, are problematic because they can inactivate all classes of β-lactams except aztreonam.
Małgorzata Brauncajs, Filip Bielec, Marlena Malinowska, Dorota Pastuszak-Lewandoska   +3 more
doaj   +1 more source

Characterization of Metallo β-Lactamase Producing Enterobacterales Isolates with Susceptibility to the Aztreonam/Avibactam Combination [PDF]

Background/Objectives: Metallo-β-lactamases (MBLs) in Enterobacterales and other Gram-negative organisms pose significant public health threats due to their association with multidrug resistance (MDR).
De Maio F., Posteraro B., Sanguinetti M., Spanu T.   +3 more
core   +1 more source

Antimicrobial susceptibility of clinically important carbapenem-resistant Enterobacterales towards standard and new antibiotics

Journal of Global Antimicrobial Resistance
AIM: The aim of this work is to study carbapenem-resistant Enterobacterales (CRE) incidence, carbapenemase types and antimicrobial susceptibility of the strains to standard and new antibiotics.
Deniz Hamidov, Emma Keuleyan, Theodor Todorov, Radoslava Vazharova, Georgi Todorov, Atanas Syarov   +5 more
doaj   +1 more source

New Antibiotics Against Multidrug-Resistant Gram-Negative Bacteria in Liver Transplantation: Clinical Perspectives, Toxicity, and PK/PD Properties [PDF]

Antimicrobial resistance is a growing global health problem, and it is especially relevant among liver transplant recipients where infections, particularly when caused by microorganisms with a difficult-to-treat profile, are a significant cause of ...
Alagna, Laura, Bandera, Alessandra, Lombardi, Andrea, Mangioni, Davide, Palomba, Emanuele, Tonizzo, Anna, Viero, Giulia   +6 more
core   +1 more source

Epidemiology and antimicrobial susceptibility profiles of Enterobacterales causing bloodstream infections before and during COVID-19 pandemic: Results of the Study for Monitoring Antimicrobial Resistance Trends (SMART) in Taiwan, 2018–2021

Journal of Microbiology, Immunology and Infection
Background: The coronavirus disease 2019 (COVID-19) pandemic has contributed to the spread of antimicrobial resistance, including carbapenem-resistant Enterobacterales.
Yu-Lin Lee, Chun-Eng Liu, Hung-Jen Tang, Yu-Tsung Huang, Yao-Shen Chen, Po-Ren Hsueh, Wen-Chien Ko, Po-Liang Lu, Chun-Eng Liu, Kenneth Yin-Ching Chuang, Fu-Der Wang, Yao-Shen Chen, Min-Chi Lu, Mao-Wang Ho   +13 more
doaj   +1 more source