Results 71 to 80 of about 3,967 (153)

Antimicrobial activity of ceftazidime-avibactam against KPC-2-producing Enterobacterales: a cross-combination and dose-escalation titration study with relebactam and vaborbactam

Microbiology Spectrum
With the introduction of ceftazidime-avibactam worldwide, the antimicrobial activity of new β-lactam/β-lactamase inhibitors (BL/BLIs) needs to be investigated.
Min Seo Kang, Jin Yang Baek, Jae-Hoon Ko, Sun Young Cho, Keon Young Lee, Young Ho Lee, Jinyoung Yang, Tae Yeul Kim, Hee Jae Huh, Nam Yong Lee, Kyungmin Huh, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck   +13 more
doaj   +1 more source

Diversity of resistance mechanisms in carbapenem-resistant Enterobacteriaceae at a health care system in Northern California, from 2013 to 2016 [PDF]

, 2019
The mechanism of resistance in carbapenem-resistant Enterobacteriaceae (CRE) has therapeutic implications. We comprehensively characterized emerging mechanisms of resistance in CRE between 2013 and 2016 at a health system in Northern California.
Andermann, Tessa, Banaei, Niaz, Bhatt, Ami, Budvytiene, Indre, Gaur, Rajiv L., Gomez, Carlos A., Kültz, Dietmar, Sandlund, Johanna, Senchyna, Fiona, Shi, Gongyi, Tamburini, Fiona B., Tenover, Fred C., Tickler, Isabella A., Tremintin, Guillaume, Truong, Cynthia, Watz, Nancy   +15 more
core   +1 more source

Infections Management in the Lung Transplant Setting in Italy: A Web‐Survey

Transplant Infectious Disease, Volume 27, Issue 2, March/April 2025.
A web survey has revealed significant variation in infection management practices across Italian lung transplant centers. These differences encompass key aspects of infection prevention and control, including antibiotic protocols and cytomegalovirus prophylaxis, underscoring a lack of consistency in fundamental strategies.
Andrea Lombardi, Paolo Grossi, Malgorzata Mikulska, Maddalena Giannella, Renato Pascale, Serena Marinello, Francesca Montagnani, Elena Seminari, Silvia Corcione, Alessandra Bandera, Alessandro Bertani, Alessandra Mularoni, for the Infection Prevention and Treatment Working Group of the LUNG‐SITO study group   +12 more
wiley   +1 more source

ARGONAUT-IV: susceptibility of carbapenemase-producing Klebsiella pneumoniae to the oral bicyclic boronate β-lactamase inhibitor ledaborbactam combined with ceftibuten. [PDF]

Ledaborbactam (formerly VNRX-5236), a bicyclic boronate β-lactamase inhibitor with activity against class A, C, and D β-lactamases, is under development as an orally bioavailable etzadroxil prodrug (VNRX-7145) in combination with ceftibuten for the ...
Abdelhamed, Ayman M, Bethel, Christopher R, Bonomo, Robert A, Fowler, Vance G, Good, Caryn E, Hujer, Andrea M, Hujer, Kristine M, Jacobs, Michael R, Mack, Andrew R, Marshall, Steven H, Moeck, Greg, Papp-Wallace, Krisztina M, Patel, Robin, Rhoads, Daniel D, Six, David A, Uehara, Tsuyoshi, van Duin, David   +16 more
core   +2 more sources

α‐Triazolylboronic Acids: A Novel Scaffold to Target FLT3 in AML

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
Boronic acids represent an intriguing and unexplored class of compounds in the context of acute myeloid leukemia (AML), and they are only scantly reported as inhibitors of protein kinases. The screening of an in‐house library of boronic compounds identified α‐triazolylboronic acids as a novel chemotype for targeting FLT3 in AML. Selected compounds show
Maria Luisa Introvigne, Lorenza Destro, Luca Mologni, Valentina Crippa, Paolo Zardi, Francesco Fini, Fabio Prati, Emilia Caselli, Alfonso Zambon   +8 more
wiley   +1 more source

Cefiderocol‐Resistant Elizabethkingia anophelis Bacteremia Following WATCHMAN Implantation: A Case Report and Review of the Literature

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Elizabethkingia anophelis is an emerging pathogen associated with nosocomial and community outbreaks. Treatment of infection caused by E. anophelis is not well‐defined given its extensive drug resistance profile, and infection carries a poor prognosis. E.
Anna DeFrank, Michael Bosco, Sigridh Muñoz Gómez, Amit Dhaliwal, Priya Gusain   +4 more
wiley   +1 more source

A Case of Nocardia kroppenstedtii Infection Successfully Treated With a Multidisciplinary Approach

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Nocardia species constitute a diverse group of microorganisms classified as aerobic actinomyces. Among these species, many have been implicated as causative agents of severe human infections, particularly in immunocompromised patients, affecting lungs, skin, and nervous system.
Francesco Foglia, Annalisa Ambrosino, Giuseppe Greco, Annalisa Chianese, Carla Zannella, Francesca Cinone, Alfonso Reginelli, Diego Sandro Giordano, Giovanni Tortorella, Maria Teresa Laieta, Anna De Filippis, Massimiliano Galdiero, Rita Greco, Emiliana Finamore, Rajib Chowdhury   +14 more
wiley   +1 more source

Carbapenem‐Resistant Klebsiella pneumoniae Isolated From a Patient in a Midwestern U.S. Hospital With a History of Indian Travel: Therapeutic Strategies and Clinical Outcomes

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Carbapenemases have had increasing prevalence within the United States and worldwide. Here, we present a case of carbapenem‐resistant Klebsiella pneumoniae (CRKP) which is unique due to the rarity of multiple mechanisms of resistance within the Klebsiella pneumoniae harboring New Delhi metallo‐β‐lactamases (NDM), oxacillinase‐48 (OXA‐48)‐like, and ...
Christopher Phan, Kristen Tsai, Christian M. Gill, Robin Chamberland, Christian Hendrix, Rong Hou, Dawei Cui   +6 more
wiley   +1 more source

Spotlight commentary: Treatment of multidrug‐resistant Gram‐negative infections in the era of growing antimicrobial resistance

British Journal of Clinical Pharmacology, Volume 91, Issue 9, Page 2485-2489, September 2025.
Luka Bielen, Andro Vujević, Luka Csenar
wiley   +1 more source

Cockroaches as Reservoirs, Vectors, and Potential Sentinels of Multidrug‐Resistant Bacteria in Ugandan Communities: A Retrospective Analysis

Global Health, Epidemiology and Genomics, Volume 2025, Issue 1, 2025.
Background: Cockroaches could play a role in the transmission dynamics of antimicrobial‐resistant bacteria (ARB) at variable interfaces in Ugandan communities, acting as both reservoirs and vectors. This study investigated the burden and diversity of ARB carried by cockroaches in human settlements in Uganda, so as to understand their role in the spread
Steven Kakooza, Paul Ssajjakambwe, Rebecca Nalubega, Betty Namazi, Aisha Nantume, Geoffrey Ssentamu, Esther Nabatta, David Nalumenya, Mariam Wanyana, Damien F. N. Munyiirwa, Dorcus Namuyinda, Sayaka Tsuchida, Kazunari Ushida, John Baligwamunsi Kaneene, Omar Enzo Santangelo   +14 more
wiley   +1 more source