Results 81 to 90 of about 3,967 (153)

Antimicrobial susceptibility of enterobacterales causing bloodstream infection in United States medical centres: comparison of aztreonam-avibactam with beta-lactams active against carbapenem-resistant enterobacterales

BMC Infectious Diseases
Background Bloodstream infection (BSI) is associated with poor outcomes especially when effective antimicrobial therapy and control of infection source are delayed.
Helio S. Sader, John H. Kimbrough, Rodrigo E. Mendes, Mariana Castanheira   +3 more
doaj   +1 more source

Revisiting the Metallo‐β‐Lactamase–Mediated Antibiotic Resistance: Exploring Novel Mechanisms and Therapeutic Strategies

International Journal of Microbiology, Volume 2025, Issue 1, 2025.
β‐Lactam resistance is one of the major health concerns today, primarily due to enzymes called β‐lactamases. Metallo‐β‐lactamases (MβLs) can cleave a wide range of β‐lactam antibiotics, including carbapenems. These enzymes require zinc (Zn) ions to function and can be inhibited by conventional β‐lactamase inhibitors.
Jahanvi Saini, Silvi Gautam, Divakar Sharma, Ankit Khanduri, Divya Venugopal, Guilherme Dilarri   +5 more
wiley   +1 more source

In Vitro Activity of “Old” and “New” Antimicrobials against the Klebsiella pneumoniae Complex

Antibiotics
The Klebsiella pneumoniae complex is a commonly isolated bacteria in human infections. These opportunistic pathogens pose a serious threat to public health due to their potential transmission to the human population.
Alicja Sękowska
doaj   +1 more source

A Focused Review on Commercially Available Automated Systems for Antibiotic Susceptibility Testing

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
The battle against antibiotic resistance demands innovative solutions for efficient and accurate antibiotic susceptibility testing (AST). Traditional methods, though reliable, are often time‐consuming and labor‐intensive, limiting their ability to provide timely results in clinical settings.
Qumars Ghavami, Haider Abd Ulhai Nasser, Seyedeh Shadi Vaziri, Majid Taati Moghadam, Rajib Chowdhury   +4 more
wiley   +1 more source

Multicenter clinical evaluation of Etest meropenem-vaborbactam (bioMérieux) for susceptibility testing of Enterobacterales (Enterobacteriaceae) and Pseudomonas aeruginosa [PDF]

, 2019
Meropenem-vaborbactam (MEV) is a novel carbapenem-beta-lactamase inhibitor combination antibiotic approved by the U.S. Food and Drug Administration (FDA) for treatment of complicated urinary tract infections, including pyelonephritis, in adults.
Anglade, Claire, Bridon, Laurence, Burnham, Carey-Ann D, Davies, Leanne, Garner, Omai B, Garrett, Sheri, Jean, Sophonie, Richards, Jennifer, Wallace, Meghan, Wootton, Mandy   +9 more
core   +1 more source

Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance [PDF]

, 2020
The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim of this review is to provide a comprehensive assessment of the mechanisms
Bassetti, Matteo, Giacobbe, Daniele Roberto, Peghin, Maddalena, Sepulcri, Chiara, Vena, Antonio   +4 more
core   +1 more source

Activity of Aztreonam-avibactam and other β-lactamase inhibitor combinations against Gram-negative bacteria isolated from patients hospitalized with pneumonia in United States medical centers (2020–2022)

BMC Pulmonary Medicine
Background Initial antimicrobial therapy for pneumonia is frequently empirical and resistance to antimicrobial agents represents a great challenge to the treatment of patients hospitalized with pneumonia.
Helio S. Sader, Rodrigo E. Mendes, S. J. Ryan Arends, Timothy B. Doyle, Mariana Castanheira   +4 more
doaj   +1 more source

In Vitro Activities of Cefiderocol, Ceftazidime–Avibactam, Meropenem–Vaborbactam, Imipenem–Relebactam and Eravacycline Against Carbapenem-Resistant Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance
AIM/BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections are a significant global threat due to the limited treatment options. In this study, in vitro activities of novel antimicrobial agents were investigated against CRKP strains ...
FATMA SENA TÜRKDOĞAN, Betigul Ongen
doaj   +1 more source

Diagnostic algorithm for the detection of carbapenemases and extended-spectrum β-lactamases in carbapenem-resistant Pseudomonas aeruginosa [PDF]

Pseudomonas aeruginosa can acquire carbapenem resistance through various mechanisms, including genomic mutations leading to the overexpression of efflux pumps, intrinsic AmpC-β-lactamase, and/or reduced permeability, and/or through the acquisition of ...
Egli, Adrian, Garcia-Verellen, Laia, Hinic, Vladimira, Keller, Peter M, Kolesnik-Goldmann, Natalia, Mancini, Stefano, Nolte, Oliver, Roloff, Tim, Seth-Smith, Helena M B, Syed, Muhammad Ali, Ullah, Irfan   +10 more
core   +1 more source

EVALUATION OF THE MINIMUM INHIBITORY CONCENTRATION OF MEROPENEM AND NEW THERAPEUTIC OPTIONS FOR SERRATIA MARCESCENS AND MORGANELLACEAE ENTEROBACTERALES WITH REDUCED SUSCEPTIBILITY TO MEROPENEM

Brazilian Journal of Infectious Diseases
Introduction/Objective: Serratia marcescens and Enterobacterales of the Morganellaceae family are associated with infections in different sites and exhibit an expected phenotype of resistance to several antimicrobials, making therapeutic options very ...
Lívia Medeiros, Eduarda Castro Oliveira, Mariana Preussler Mott, Bruno Watanabe, Rodrigo Minuto Paiva, Larissa Lutz   +5 more
doaj   +1 more source