Results 51 to 60 of about 2,668 (112)

A Focused Review on Commercially Available Automated Systems for Antibiotic Susceptibility Testing

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
The battle against antibiotic resistance demands innovative solutions for efficient and accurate antibiotic susceptibility testing (AST). Traditional methods, though reliable, are often time‐consuming and labor‐intensive, limiting their ability to provide timely results in clinical settings.
Qumars Ghavami, Haider Abd Ulhai Nasser, Seyedeh Shadi Vaziri, Majid Taati Moghadam, Rajib Chowdhury   +4 more
wiley   +1 more source

Expanding the β‐Lactamase Family in the Human Microbiome

Advanced Science, Volume 11, Issue 46, December 11, 2024.
β‐lactam resistance is mainly driven by β‐lactamases. The study analyzes 1369 characterized and 16 204 putative β‐lactamases, identifying nine from eight clusters. The highest gut β‐lactamase abundance is found in Japan and the lowest in Fiji. β‐lactamase levels correlate with β‐lactam use and income, increasing in colorectal cancer and cardiovascular ...
Baolei Jia, Ju Hye Baek, Jae Kyeong Lee, Ying Sun, Kyung Hyun Kim, Ji Young Jung, Che Ok Jeon   +6 more
wiley   +1 more source

Antimicrobial susceptibility of enterobacterales causing bloodstream infection in United States medical centres: comparison of aztreonam-avibactam with beta-lactams active against carbapenem-resistant enterobacterales

BMC Infectious Diseases
Background Bloodstream infection (BSI) is associated with poor outcomes especially when effective antimicrobial therapy and control of infection source are delayed.
Helio S. Sader, John H. Kimbrough, Rodrigo E. Mendes, Mariana Castanheira   +3 more
doaj   +1 more source

Recovery of clinically relevant multidrug‐resistant Klebsiella pneumoniae lineages from wastewater in Kumasi Metropolis, Ghana

Environmental Microbiology Reports, Volume 16, Issue 6, December 2024.
This study revealed a significant prevalence of antimicrobial resistance in Klebsiella pneumoniae and Pseudomonas aeruginosa isolates from wastewater, exhibiting diverse resistance profiles, including co‐resistance to antibiotics and heavy metals. These findings underscore the critical need for continuous One Health surveillance to mitigate the spread ...
Amen Ekhosuehi, Odion O. Ikhimiukor, Helen Michelle Korkor Essandoh, Nana Yaw Asiedu, Isoken Tito Aighewi, Gabriel Temitope Sunmonu, Erkison Ewomazino Odih, Anderson O. Oaikhena, Dorothy Cyril‐Okoh, Clara Yeboah, Iruka N. Okeke   +10 more
wiley   +1 more source

In Vitro Activity of “Old” and “New” Antimicrobials against the Klebsiella pneumoniae Complex

Antibiotics
The Klebsiella pneumoniae complex is a commonly isolated bacteria in human infections. These opportunistic pathogens pose a serious threat to public health due to their potential transmission to the human population.
Alicja Sękowska
doaj   +1 more source

Activity of Aztreonam-avibactam and other β-lactamase inhibitor combinations against Gram-negative bacteria isolated from patients hospitalized with pneumonia in United States medical centers (2020–2022)

BMC Pulmonary Medicine
Background Initial antimicrobial therapy for pneumonia is frequently empirical and resistance to antimicrobial agents represents a great challenge to the treatment of patients hospitalized with pneumonia.
Helio S. Sader, Rodrigo E. Mendes, S. J. Ryan Arends, Timothy B. Doyle, Mariana Castanheira   +4 more
doaj   +1 more source

In Vitro Activities of Cefiderocol, Ceftazidime–Avibactam, Meropenem–Vaborbactam, Imipenem–Relebactam and Eravacycline Against Carbapenem-Resistant Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance
AIM/BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections are a significant global threat due to the limited treatment options. In this study, in vitro activities of novel antimicrobial agents were investigated against CRKP strains ...
FATMA SENA TÜRKDOĞAN, Betigul Ongen
doaj   +1 more source

EVALUATION OF THE MINIMUM INHIBITORY CONCENTRATION OF MEROPENEM AND NEW THERAPEUTIC OPTIONS FOR SERRATIA MARCESCENS AND MORGANELLACEAE ENTEROBACTERALES WITH REDUCED SUSCEPTIBILITY TO MEROPENEM

Brazilian Journal of Infectious Diseases
Introduction/Objective: Serratia marcescens and Enterobacterales of the Morganellaceae family are associated with infections in different sites and exhibit an expected phenotype of resistance to several antimicrobials, making therapeutic options very ...
Lívia Medeiros, Eduarda Castro Oliveira, Mariana Preussler Mott, Bruno Watanabe, Rodrigo Minuto Paiva, Larissa Lutz   +5 more
doaj   +1 more source

Activity of β-Lactamase Inhibitor Combinations Against Enterobacterales Isolated from Patients with Intra-Abdominal Infection from United States Medical Centres (2019–2023)

Antibiotics
Objective: To evaluate the antimicrobial susceptibility of Enterobacterales isolated from patients with intra-abdominal infections (IAI) in United States (US) medical centres.
Helio S. Sader, John H. Kimbrough, Marisa L. Winkler, Rodrigo E. Mendes, Mariana Castanheira   +4 more
doaj   +1 more source

Aztreonam Combinations with Avibactam, Relebactam, and Vaborbactam as Treatment for New Delhi Metallo-β-Lactamase-Producing Enterobacterales Infections—In Vitro Susceptibility Testing

Pharmaceuticals
Antimicrobial resistance is a major global health issue. Metallo-β-lactamases (MBL), in particular, are problematic because they can inactivate all classes of β-lactams except aztreonam.
Małgorzata Brauncajs, Filip Bielec, Marlena Malinowska, Dorota Pastuszak-Lewandoska   +3 more
doaj   +1 more source