Results 141 to 150 of about 2,951 (216)

Unusual chemistries in fungal meroterpenoid biosynthesis

Current Opinion in Chemical Biology, 2016
Meroterpenoids are polyketide and terpenoid hybrid natural products with remarkable biological activities. Recent progress in fungal meroterpenoid biosynthesis has revealed several unusual enzyme reactions and novel enzymes, including unique terpene cyclization reactions by a novel family of membrane-bound terpene cyclases and post-cyclization ...
Yudai, Matsuda, Takayoshi, Awakawa, Takahiro, Mori, Ikuro, Abe   +3 more
openaire   +2 more sources

Meroterpenoids with bicyclic polyprenylated acylphloroglucinol scaffold and anti-inflammatory activity from Hypericum lancasteri.

Phytochemistry
Twelve undescribed meroterpenoids possessing bicyclic polyprenylated acylphloroglucinol (BPAP) scaffold, (±)-lancasternoids A-D and lancasternoids E-H, together with fourteen known analogues, were isolated from Hypericum lancasteri (Hypericaceae) and ...
Jin‐Qiu You, Yun-Qi Jin, Yu-Meng Miao, Xinyu Sun, Jia-Yu Yang, Jin-Chang Huang, Jing-Ya Li, Ai‐Jun Hou   +7 more
semanticscholar   +1 more source

Meroterpenoid enantiomers from Ganoderma sinensis

Fitoterapia, 2016
Zizhines A-F (1-6), six pairs of new meroterpenoid enantiomers and a known meroterpenoid (7) were isolated from the fruiting bodies of Ganoderma sinensis. The structures and absolute configurations of the new substances were assigned by spectroscopic and computational methods.
Wen-Wen, Cao, Qi, Luo, Yong-Xian, Cheng, Shu-Mei, Wang   +3 more
openaire   +2 more sources

Natural Lysine-Reactive Meroterpenoids, Stachybenzals A-C, as Covalent Asparagine Synthetase Inhibitors.

Journal of Natural Products
Asparagine synthetase (ASNS) is a promising molecular target for cancer chemotherapy. We previously reported bisabosqual A (Bis A), a natural covalent ASNS inhibitor that binds to K556 of ASNS.
Lei Zhang, Yanjun Pan, H. Uekusa, Takehiro Suzuki, N. Dohmae, Akira Hattori, Yoshinori Hirano, Hideaki Kakeya   +7 more
semanticscholar   +1 more source

Racemic meroterpenoids from Ganoderma cochlear

Fitoterapia, 2018
Ganoderma cochlear, as edible and medicinal fungus, has long been used to prevent and treat various diseases. As our continuously phytochemical investigation of this fungus, a HPLC-UV-guided method led to the isolation of nine previously undescribed aromatic meroterpenoids with different ring systems, including six pairs of racemates, (±)-cochlearins A-
Xingrong, Peng, Xia, Wang, Long, Chen, Han, Yang, Lei, Li, Shuangyang, Lu, Lin, Zhou, Minghua, Qiu   +7 more
openaire   +2 more sources

Meroterpenoids? A historical and critical review of this biogenetic determinant

Natural Product Reports, 2023
The word meroterpenoid was introduced by Conforth to qualify a biosynthetic pathway. Its use as natural products is at the origin of exclusions and confusions which are discussed here.
Eddy Goyer, Catherine Lavaud, Georges Massiot   +2 more
openaire   +3 more sources

Cannabinoid-like meroterpenoids from Peperomia incana

Phytochemistry, 2023
Ten previously undescribed metabolites were isolated from Peperomia incana (Haw.) A. Dietr. (Piperaceae), among which four contained a chromene moiety, two were identified as meroterpene lactones, and four were cannabinoid-like compounds. While the chemical structures of the compounds were assigned based on HRESIMS and 1D and 2D-NMR spectra analyses ...
Hamed, Abdelaaty, Yamaguchi, Lydia Fumiko, Yn, Estela, Morante, es Valencia, Spira, Beny, Stammler, Hans Georg, Gaafary, Menna El, Ziegler, David, Syrovets, Tatiana, Simmet, Thomas, Kato, Massuo Jorge   +10 more
openaire   +4 more sources

Cellular and biochemical antileukemic mechanisms of the meroterpenoid Oncocalyxone A

Journal of Toxicology and Environmental Health, Part A, 2020
Oncocalyxone A, a 1,4-benzoquinone derived from Cordia oncocalyx, exhibits anti-inflammatory, antimicrobial and antidiabetic properties. The aim of this study was to (1) examine the cytotoxic actions of oncocalyxone A on human normal and tumor cell lines and (2) determine mechanistic actions underlying effects upon leukemia cells using cellular and ...
Aline Borba Sbardelotto, Francisco Washington Araújo Barros-Nepomuceno, Bruno Marques Soares, Bruno Coêlho Cavalcanti, Rayran Walter Ramos de Sousa, Marcília Pinheiro da Costa, Otília Deusdênia Loiola Pessoa, Cláudia Pessoa, Paulo Michel Pinheiro Ferreira   +8 more
openaire   +2 more sources

A series of meroterpenoids with highly oxygenated skeletons from the endophytic fungus Penicillium sp. and their anti-inflammatory activities.

Phytochemistry
Four undescribed meroterpenoids, peniclactone D (1) and penichrodrimanins A-C (5-7), along with five known analogues (2-4, 8, and 9), were isolated from the fungus Penicillium sp. GDGJ-285. Their structures and absolute configurations were established on
Tuxiang Mo, Liu-Xia Lv, Xi-shan Huang, Jia-Tong Zhou, Qian Wu, Xian-Hua He, Li-Qi Liang, Wei-Feng Xu, Jun Li, Ruiyun Yang   +9 more
semanticscholar   +1 more source

Sustainable bioproduction of triterpenoid sapogenins and meroterpenoids in a metabolically engineered medicinal mushroom

Green Chemistry
Metabolic engineering of a medicinal mushroom for sustainable bioproduction of oleanolic and ursolic acids and meroterpenoids. Oleanolic and ursolic acid production was enhanced by reconstructing the terpenoid backbone biosynthetic pathway.
F. Azi, Xiaomei Dai, Yuxiang Hong, Liqing Yin, Mingsheng Dong, Peng Xu   +5 more
semanticscholar   +1 more source