Results 151 to 160 of about 2,271 (197)

Ring contraction and ring expansion reactions in terpenoid biosynthesis and their application to total synthesis. [PDF]

Beilstein J Org Chem
Kratena N, Heinzig N, Gärtner P.
europepmc   +1 more source

Combining biocatalytic and radical retrosynthesis for efficient chemoenzymatic synthesis of natural products.

Chem Soc Rev
Renata H.
europepmc   +1 more source

Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids

Angewandte Chemie - International Edition, 2020
AbstractFungal meroterpenoids are a diverse group of hybrid natural products with impressive structural complexity and high potential as drug candidates. In this work, we evaluate the promiscuity of the early structure diversity‐generating step in fungal meroterpenoid biosynthetic pathways: the multibond‐forming polyene cyclizations catalyzed by the ...
Makoto Fujita, John A. Porco, Dean J Tantillo   +2 more
exaly   +6 more sources

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A Multifunctional Cytochrome P450 and a Meroterpenoid Cyclase in the Biosynthesis of Fungal Meroterpenoid Atlantinone B

Organic Letters, 2022
The biosynthetic gene cluster of atlantinone B (10) was discovered in Penicillium chrysogenum MT-40. A multifunctional cytochrome P450 (AtlD) encoded by the cluster is responsible for the formation of the unique lactone-bridged ring and the 16β-hydroxyl of atlantinone B, and a new terpene cyclase (AtlC) can unprecedentedly accept the demethylated ...
Bo-wen Qi, Na Li, Bei-bei Zhang, Ze-kun Zhang, Wen-jing Wang, Xiao Liu, Juan Wang, Takayoshi Awakawa, Peng-fei Tu, Ikuro Abe, She-po Shi, Jun Li   +11 more
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The chemistry and biology of fungal meroterpenoids (2009–2019)

Organic & Biomolecular Chemistry, 2021
The structural features, biological activities, and fungal biodiversity of 1585 new meroterpenoids were comprehensively overviewed (2009–2019).
Minghua Jiang, Zhenger Wu, Lan Liu, Senhua Chen   +3 more
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Unusual chemistries in fungal meroterpenoid biosynthesis

Current Opinion in Chemical Biology, 2016
Meroterpenoids are polyketide and terpenoid hybrid natural products with remarkable biological activities. Recent progress in fungal meroterpenoid biosynthesis has revealed several unusual enzyme reactions and novel enzymes, including unique terpene cyclization reactions by a novel family of membrane-bound terpene cyclases and post-cyclization ...
Yudai, Matsuda, Takayoshi, Awakawa, Takahiro, Mori, Ikuro, Abe   +3 more
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Meroterpenoid enantiomers from Ganoderma sinensis

Fitoterapia, 2016
Zizhines A-F (1-6), six pairs of new meroterpenoid enantiomers and a known meroterpenoid (7) were isolated from the fruiting bodies of Ganoderma sinensis. The structures and absolute configurations of the new substances were assigned by spectroscopic and computational methods.
Wen-Wen, Cao, Qi, Luo, Yong-Xian, Cheng, Shu-Mei, Wang   +3 more
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Racemic meroterpenoids from Ganoderma cochlear

Fitoterapia, 2018
Ganoderma cochlear, as edible and medicinal fungus, has long been used to prevent and treat various diseases. As our continuously phytochemical investigation of this fungus, a HPLC-UV-guided method led to the isolation of nine previously undescribed aromatic meroterpenoids with different ring systems, including six pairs of racemates, (±)-cochlearins A-
Xingrong, Peng, Xia, Wang, Long, Chen, Han, Yang, Lei, Li, Shuangyang, Lu, Lin, Zhou, Minghua, Qiu   +7 more
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Cannabinoid-like meroterpenoids from Peperomia incana

Phytochemistry, 2023
Ten previously undescribed metabolites were isolated from Peperomia incana (Haw.) A. Dietr. (Piperaceae), among which four contained a chromene moiety, two were identified as meroterpene lactones, and four were cannabinoid-like compounds. While the chemical structures of the compounds were assigned based on HRESIMS and 1D and 2D-NMR spectra analyses ...
Hamed, Abdelaaty, Yamaguchi, Lydia Fumiko, Yn, Estela, Morante, es Valencia, Spira, Beny, Stammler, Hans Georg, Gaafary, Menna El, Ziegler, David, Syrovets, Tatiana, Simmet, Thomas, Kato, Massuo Jorge   +10 more
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Cellular and biochemical antileukemic mechanisms of the meroterpenoid Oncocalyxone A

Journal of Toxicology and Environmental Health, Part A, 2020
Oncocalyxone A, a 1,4-benzoquinone derived from Cordia oncocalyx, exhibits anti-inflammatory, antimicrobial and antidiabetic properties. The aim of this study was to (1) examine the cytotoxic actions of oncocalyxone A on human normal and tumor cell lines and (2) determine mechanistic actions underlying effects upon leukemia cells using cellular and ...
Aline Borba Sbardelotto, Francisco Washington Araújo Barros-Nepomuceno, Bruno Marques Soares, Bruno Coêlho Cavalcanti, Rayran Walter Ramos de Sousa, Marcília Pinheiro da Costa, Otília Deusdênia Loiola Pessoa, Cláudia Pessoa, Paulo Michel Pinheiro Ferreira   +8 more
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