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Background: Since November 2019, when the novel coronavirus arose in Wuhan City, over 188 million people worldwide have been infected with COVID-19. It is the third coronavirus outbreak in the twenty-first century.
Manas Pustake+8 more
doaj +1 more source
Emerging and reemerging infectious diseases are global public concerns. With the outbreak of unknown pneumonia in Wuhan, China in December 2019, a new coronavirus, SARS‐CoV‐2 has been attracting tremendous attention. Rapid and accurate laboratory testing
Ying Yan, Le Chang, Lunan Wang
semanticscholar +1 more source
Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Memish, Ziad A.
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IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes.
Type 1 IFNs (IFN-I) generally protect mammalian hosts from virus infections, but in some cases, IFN-I is pathogenic. Because IFN-I is protective, it is commonly used to treat virus infections for which no specific approved drug or vaccine is available ...
Rudragouda Channappanavar+9 more
semanticscholar +1 more source
Does SARS‐CoV‐2 has a longer incubation period than SARS and MERS?
The outbreak of a novel coronavirus (SARS‐CoV‐2) since December 2019 in Wuhan, the major transportation hub in central China, became an emergency of major international concern.
Xuan Jiang, S. Rayner, M. Luo
semanticscholar +1 more source
Kevlar: A Mapping-Free Framework for Accurate Discovery of De Novo Variants. [PDF]
De novo genetic variants are an important source of causative variation in complex genetic disorders. Many methods for variant discovery rely on mapping reads to a reference genome, detecting numerous inherited variants irrelevant to the phenotype of ...
Brown, C Titus+2 more
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Optimized small-molecule 3C-like protease inhibitors show potency against human coronaviruses in both cell culture and a mouse model. Targeting coronavirus 3CLpro Coronavirus 3C-like proteases (3CLpro) are attractive therapeutic targets because they play
A. Rathnayake+11 more
semanticscholar +1 more source
Hematologic, hepatic, and renal function changes in hospitalized patients with Middle East respiratory syndrome coronavirus [PDF]
Background There are no longitudinal data on the changes in hematologic, hepatic, and renal function findings in patients with Middle East respiratory syndrome coronavirus (MERS‐CoV) infection. Methods This is a retrospective cohort study of 16 MERS‐
Abbasi, S.+5 more
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MERS, SARS and other coronaviruses as causes of pneumonia
Human coronaviruses (HCoVs) have been considered to be relatively harmless respiratory pathogens in the past. However, after the outbreak of the severe acute respiratory syndrome (SARS) and emergence of the Middle East respiratory syndrome (MERS), HCoVs ...
Yu-dong Yin, R. Wunderink
semanticscholar +1 more source
Nosocomial infections among patients with COVID-19, SARS and MERS: a rapid review and meta-analysis
Background: COVID-19, a disease caused by SARS-CoV-2 coronavirus, has now spread to most countries and regions of the world. As patients potentially infected by SARS-CoV-2 need to visit hospitals, the incidence of nosocomial infection can be expected to ...
Qi Zhou+19 more
semanticscholar +1 more source