Results 71 to 80 of about 467,339 (358)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

MERS, SARS and other coronaviruses as causes of pneumonia

Respirology (Carlton South. Print), 2017
Human coronaviruses (HCoVs) have been considered to be relatively harmless respiratory pathogens in the past. However, after the outbreak of the severe acute respiratory syndrome (SARS) and emergence of the Middle East respiratory syndrome (MERS), HCoVs ...
Y. Yin, R. Wunderink
semanticscholar   +1 more source

Nosocomial infections among patients with COVID-19, SARS and MERS: a rapid review and meta-analysis

medRxiv, 2020
Background: COVID-19, a disease caused by SARS-CoV-2 coronavirus, has now spread to most countries and regions of the world. As patients potentially infected by SARS-CoV-2 need to visit hospitals, the incidence of nosocomial infection can be expected to ...
Qi Zhou, Yelei Gao, Xingmei Wang, R. Liu, Peipei Du, Xiaoqing Wang, Xianzhuo Zhang, S. Lu, Zijun Wang, Q. Shi, Weiguo Li, Yanfang Ma, Xufei Luo, T. Fukuoka, H. Ahn, Myeong Soo Lee, E. Liu, Yaolong Chen, Z. Luo, Kehu Yang   +19 more
semanticscholar   +1 more source

MERS-COV [PDF]

International Journal of Infectious Diseases, 2014
Beuy Joob, Viroj Wiwanitkit
  +8 more sources

Spaced seeds improve k-mer-based metagenomic classification [PDF]

, 2015
Metagenomics is a powerful approach to study genetic content of environmental samples that has been strongly promoted by NGS technologies. To cope with massive data involved in modern metagenomic projects, recent tools [4, 39] rely on the analysis of k ...
Brinda, Karel, Kucherov, Gregory, Sykulski, Maciej   +2 more
core   +2 more sources

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Predicting COVID-19 using past pandemics as a guide: how reliable were mathematical models then, and how reliable will they be now?

Mathematical Biosciences and Engineering, 2020
During the earliest stages of a pandemic, mathematical models are a tool that can be imple-mented quickly. However, such models are based on meagre data and limited biological understanding.
Christian Costris-Vas, Elissa J. Schwartz , Robert Smith?   +2 more
doaj   +1 more source

Product of natural evolution (SARS, MERS, and SARS-CoV-2); deadly diseases, from SARS to SARS-CoV-2

Human Vaccines & Immunotherapeutics, 2021
SARS-CoV-2, the virus causing COVID-19, is a single-stranded RNA virus belonging to the order Nidovirales, family Coronaviridae, and subfamily Coronavirinae.
Mohamad Hesam Shahrajabian, Wenli Sun, Qi Cheng   +2 more
doaj   +1 more source

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2

Journal of Virology, 2020
The bifunctional nsp14 subunit of the coronavirus replicase contains 3′-to-5′ exoribonuclease (ExoN) and guanine-N7-methyltransferase domains. For the betacoronaviruses MHV and SARS-CoV, ExoN was reported to promote the fidelity of genome replication ...
N. Ogando, Jessika C. Zevenhoven-Dobbe, Y. van der Meer, P. Bredenbeek, C. Posthuma, E. Snijder   +5 more
semanticscholar   +1 more source

Toward Personalized Stationary Chromatography Phases: Equipping Commercial Silica Phases with Selected Peptide‐Based Binding Domains to Tailor Affinity

Advanced Materials Interfaces, EarlyView.
The 7‐mer peptide motifs QFFLFFQ, QFFEFFQ, and QFQQSFF, known as good, medium, and poor binders for the photosensitizers m‐THPC and Chlorin E6 are covalently immobilized on commercial amino‐functionalized silica particles by inverse electron‐demand Diels‐Alder ligation.
Steffen A. Busche, Lukas D. Bangert, Raoul D. Brand, Tommy Kröger, Enrico Heyl, Hans G. Börner   +5 more
wiley   +1 more source