Results 81 to 90 of about 373,900 (338)

Alignment-free sequence comparison with spaced k-mers [PDF]

, 2013
Alignment-free methods are increasingly used for genome analysis and phylogeny reconstruction since they circumvent various difficulties of traditional approaches that rely on multiple sequence alignments.
, Boden, Marcus, Horwege, Sebastian, Leimeister, Chris, Lindner, Sebastian, Morgenstern, Burkhard   +5 more
core   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Funding vaccines for emerging infectious diseases

Human Vaccines & Immunotherapeutics, 2018
Immunization has played a large role in substantially reducing the infected and death tolls from infectious diseases. In the case of emerging diseases, the identity of the pathogen responsible, as well as the time and location for the next outbreak ...
Gary Wong, Xiangguo Qiu
doaj   +1 more source

Comparative Epidemiology of Human Infections with Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses among Healthcare Personnel. [PDF]

PLoS ONE, 2016
The largest nosocomial outbreak of Middle East respiratory syndrome (MERS) occurred in South Korea in 2015. Health Care Personnel (HCP) are at high risk of acquiring MERS-Coronavirus (MERS-CoV) infections, similar to the severe acute respiratory syndrome
Shelan Liu, Ta-Chien Chan, Yu-Tseng Chu, Joseph Tsung-Shu Wu, Xingyi Geng, Na Zhao, Wei Cheng, Enfu Chen, Chwan-Chuen King   +8 more
doaj   +1 more source

Fos-sur-Mer [PDF]

ADLFI. Archéologie de la France - Informations, 2007
Identifiant de l'operation archeologique : 8399 Date de l'operation : 2007 (SU) Inventeur(s) : Marty Frederic (COL) Sur la parcelle diagnostiquee en 2006 par Brigitte De Luca (BSR PACA, 2006 : 123 124), des travaux de construction d’un immeuble ont detruit une grande partie des niveaux antiques.
Marty, Frédéric, Marty, Frédéric
openaire   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Determination of the Critical Exponents for the Isotropic-Nematic Phase Transition in a System of Long Rods on Two-dimensional Lattices: Universality of the Transition

, 2008
Monte Carlo simulations and finite-size scaling analysis have been carried out to study the critical behavior and universality for the isotropic-nematic phase transition in a system of long straight rigid rods of length $k$ ($k$-mers) on two-dimensional ...
A. J. Ramirez-Pastor, Binder K., D. A. Matoz-Fernandez, D. H. Linares, Fisher M. E., Flory P. J., Ghosh A., Kamieniarz G., Privman V., Selke W., Selke W., Tomé T., Vroege G. J.   +12 more
core   +1 more source

A fusion peptide in the spike protein of MERS coronavirus [PDF]

, 2019
Coronaviruses represent current and emerging threats for many species, including humans. Middle East respiratory syndrome-related coronavirus (MERS-CoV) is responsible for sporadic infections in mostly Middle Eastern countries, with occasional transfer ...
Benjamin W. Neuman, Earp, Entedar A. J. Alsaadi, Hu, Ian M. Jones   +4 more
core   +1 more source

Synthesis of Oligo‐Sulfonimidates by Exponential Growth via Sulfur‐Phenolate Exchange Reactions

ChemistryEurope, EarlyView.
A highly flexible iterative exponential growth strategy is used in combination with the sulfur‐phenolate exchange reaction to develop sequence‐defined oligosulfonimidates (16 mer). Combining this with sulfur‐fluorine exchange‐based iterative step growth, a bespoke 20 mer (Mw = 8.5 kDa) can be synthesized.
Yu Han, Dong‐Dong Liang, Silke Heskamp, Bo Chen, Fedor M. Miloserdov, Han Zuilhof   +5 more
wiley   +1 more source

Mini‐Hairpin DNA: Extraordinarily Stable Structure and Its Applications

Chemistry – A European Journal, EarlyView.
Mini‐hairpin DNA fragments containing GCGAAGC and GCGAAAGC form exceptionally stable hairpin‐like structures, with only two G−C pairs and one sheared G−A pair, remaining undenatured in 7 M urea and resisting nuclease digestion. These mini‐hairpin sequences frequently appear in replication and transcription origins, influence DNA sequencing fidelity ...
Michiko Kimoto, Ichiro Hirao
wiley   +1 more source