Results 11 to 20 of about 288,005 (268)

Pharmacological targeting of KDM6A and KDM6B, as a novel therapeutic strategy for treating craniosynostosis in Saethre-Chotzen syndrome

Stem Cell Research & Therapy, 2020
Background During development, excessive osteogenic differentiation of mesenchymal progenitor cells (MPC) within the cranial sutures can lead to premature suture fusion or craniosynostosis, leading to craniofacial and cognitive issues.
Clara Pribadi, Esther Camp, Dimitrios Cakouros, Peter Anderson, Carlotta Glackin, Stan Gronthos   +5 more
doaj   +1 more source

Mesenchymal Stem Cells

Experimental Biology and Medicine, 2001
Within the bone marrow stroma there exists a subset of nonhematopoietic cells referred to as mesenchymal stem or mesenchymal progenitor cells. These cells can be ex vivo expanded and induced, either in vitro or in vivo, to terminally differentiate into osteoblasts, chondrocytes, adipocytes, tenocytes, myotubes, neural cells, and hematopoietic ...
Minguell, JJ, Erices, A, Conget, P
openaire   +6 more sources

Homing of Mesenchymal Stem Cells [PDF]

Transfusion Medicine and Hemotherapy, 2008
SUMMARY: Mesenchymal stem cells (MSCs) are primarily fibroblast-like cells. Yet, once studied under conditions of shear stress when flowing along endothelial cells in vitro or in blood vessels, as well as in classic migration assays such as chemotaxis assays, MSCs have recently been found to function similarly to leukocytes in many ways.
Reinhard, Henschler, Erika, Deak, Erhard, Seifried   +2 more
openaire   +2 more sources

Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination

Epigenetics & Chromatin, 2019
Background The 5 hydroxymethylation (5hmC) mark and TET DNA dioxygenases play a pivotal role in embryonic stem cell differentiation and animal development.
Dimitrios Cakouros, Sarah Hemming, Kahlia Gronthos, Renjing Liu, Andrew Zannettino, Songtao Shi, Stan Gronthos   +6 more
doaj   +1 more source

The Impact of Mesenchymal Stem Cells on Differentiation of Hematopoietic Stem Cells [PDF]

Advanced Pharmaceutical Bulletin, 2015
Bone marrow microenvironment contains cellular and acellular compartments. The cellular compartment includes hematopoietic stem cells, mesenchymal stem cells and some other stromal cell types, while the acellular compartment is composed of scaffold ...
Mahshid Saleh, karim Shamsasanjan, Aliakbar Movassaghpourakbari, Parvin Akbarzadehlaleh, Zahra Molaeipour   +4 more
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Isolation and Characterization of Feline Wharton’s Jelly-Derived Mesenchymal Stem Cells

Veterinary Sciences, 2021
Wharton’s jelly is a well-known mesenchymal stem cell source in many species, including humans. However, there have been no reports confirming the presence of mesenchymal stem cells in Wharton’s jelly in cats.
Min-Soo Seo, Kyung-Ku Kang, Se-Kyung Oh, Soo-Eun Sung, Kil-Soo Kim, Young-Sam Kwon, Sungho Yun   +6 more
doaj   +1 more source

Sustained release of exosomes loaded into polydopamine-modified chitin conduits promotes peripheral nerve regeneration in rats

Neural Regeneration Research, 2022
Exosomes derived from mesenchymal stem cells are of therapeutic interest because of their important role in intracellular communication and biological regulation.
Ci Li, Song-Yang Liu, Meng Zhang, Wei Pi, Bo Wang, Qi-Cheng Li, Chang-Feng Lu, Pei-Xun Zhang   +7 more
doaj   +1 more source

Non-destructive, label free identification of cell cycle phase in cancer cells by multispectral microscopy of autofluorescence

BMC Cancer, 2019
Background Cell cycle analysis is important for cancer research. However, available methodologies have drawbacks including limited categorisation and reliance on fixation, staining or transformation.
Jared M. Campbell, Abbas Habibalahi, Saabah Mahbub, Martin Gosnell, Ayad G. Anwer, Sharon Paton, Stan Gronthos, Ewa Goldys   +7 more
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Standardization and quality assessment for clinical grade mesenchymal stem cells from human adipose tissue

Hematology, Transfusion and Cell Therapy, 2019
Background: Mesenchymal stem cells have immense potential in stem cell-based therapies, however there is a pre-requisite to develop a curative cell dose. Adipose tissue-derived mesenchymal stem cells are promising mainly due to their potential abundance,
Tanya Debnath, Lakshmi Kiran Chelluri
doaj   +1 more source

Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID-repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages

Haematologica, 2010
Background Bone marrow mesenchymal stem cells support proliferation and differentiation of hematopoietic progenitor cells in vitro. Since these cells constitute a rare subset of bone marrow cells, mesenchymal stem cell preparations for clinical purposes ...
Alexandra Briquet, Sophie Dubois, Sandrine Bekaert, Marie Dolhet, Yves Beguin, André Gothot   +5 more
doaj   +1 more source