Results 41 to 50 of about 5,745,585 (307)

The in vitro plasticity of hair follicle dermal and mesenchymal stem cells [PDF]

, 2008
Stem cells from the hair follicle are an easily accessible population of cells that have a broad in vitro developmental capabilities and potential for autologous replacement of damaged adult tissue.
Emmerson, Robert
core  

Bone marrow mesenchymal stem cell niches and regenerative medicine [PDF]

, 2010
Mesenchymal progenitors are a powerful tool in regenerative medicine, but suffer from a rapid loss of differentiation potential during in vitro expansion.
Di Maggio, Nunzia
core   +1 more source

GMP-compatible and xeno-free cultivation of mesenchymal progenitors derived from human-induced pluripotent stem cells

Stem Cell Research & Therapy, 2019
Background Human mesenchymal stem cells are a strong candidate for cell therapies owing to their regenerative potential, paracrine regulatory effects, and immunomodulatory activity.
Madison McGrath, Edmund Tam, Martina Sladkova, Athbah AlManaie, Matthew Zimmer, Giuseppe Maria de Peppo   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Investigating the properties of cancer stem cells and epithelial to mesenchymal transition in human prostate cancer [PDF]

, 2012
In recent years, the cancer stem cell hypothesis has emerged as a compelling but controversial model of cancer progression. Contrary to the clonal evolution model, the cancer stem cell hypothesis postulates that, akin to normal tissues, tumours are ...
Dunning-Foreman, NL
core  

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. [PDF]

, 2012
BACKGROUND: More than half of patients with multiple sclerosis have progressive disease characterised by accumulating disability. The absence of treatments for progressive multiple sclerosis represents a major unmet clinical need.
Kolappan, Madhan, Thompson, Alan J, Luan, Shi-Lu, Altmann, Daniel R, Crawley, Charles, Compston, Alastair, Patani, Rickie, Scott, Michael A, Du, Ming-Qing, Miller, David H, Michell, Andrew W, Chandran, Siddharthan, Connick, Peter, Webber, Daniel J   +13 more
core   +1 more source

Micro RNA based MSC EV engineering: Targeting the BMP2 cascade for bone repair

Frontiers in Cell and Developmental Biology, 2023
Mesenchymal stem cell derived extracellular vesicles (MSC EVs) possess excellent immunomodulatory and therapeutic properties. While beneficial, from a translational perspective, extracellular vesicles with consistent functionality and target specificity ...
Chun-Chieh Huang, Miya Kang, Kasey Leung, Yu Lu, Sajjad Shirazi, Praveen Gajendrareddy, Sriram Ravindran   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Current Issues and Regulations in Tendon Regeneration and Musculoskeletal Repair with Mesenchymal Stem Cells

, 2011
Mesenchymal stem cells are multipotent stromal cells residing within the connective tissue of most organs. Their surface phenotype has been well described.
Grange, Simon
core   +1 more source

Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches

Frontiers in Medicine
The inability to get or sustain an erection strong enough for fulfilling sexual performance is the hallmark of the common disorder known as erectile dysfunction (ED). It mostly affects a significant percentage of men worldwide, particularly those aged 40
Xiaoliang Fu, Azar Sheikholeslami, Ulanbek Zhanbyrbekuly, Faezeh Davoodi Asl, Nadiar M. Mussin, Hoda Fazaeli, Karim Daniyalov, Nader Tanideh, Nader Tanideh, Nader Tanideh, Mahdi Mahdipour, Mahdi Mahdipour, Madina A. Kurmanalina, Amin Tamadon, Amin Tamadon, Amin Tamadon   +15 more
doaj   +1 more source