Results 51 to 60 of about 5,745,585 (307)

Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells

Haematologica, 2013
The melanoma cell adhesion molecule defines mesenchymal stromal cells in the human bone marrow that regenerate bone and establish a hematopoietic microenvironment in vivo.
Sabine Stopp, Martin Bornhäuser, Fernando Ugarte, Manja Wobus, Matthias Kuhn, Sebastian Brenner, Sebastian Thieme   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Alginate Scaffolds for Mesenchymal Stem Cell Cardiac Therapy: Influence of Alginate Composition [PDF]

, 2012
Despite the success of alginate scaffolds and mesenchymal stem cells (MSCs) therapy in cardiac failure treatment, the impact of the physicochemical environment provided by alginate matrices on cell behavior has never been investigated.
Alfarano, Chiara, Ceccaldi, Caroline, Calise, Denis, Sallerin, Brigitte, Girod Fullana, Sophie, Cussac, Daniel, Parini, Angelo, Lairez, Olivier   +7 more
core   +1 more source

Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modeling the niche compartments in vitro

Haematologica, 2010
Background Hematopoietic stem cells located in the bone marrow interact with a specific microenvironment referred to as the stem cell niche. Data derived from ex vivo co-culture systems using mesenchymal stromal cells as a feeder cell layer suggest that ...
Duohui Jing, Ana-Violeta Fonseca, Nael Alakel, Fernando A. Fierro, Katrin Muller, Martin Bornhauser, Gerhard Ehninger, Denis Corbeil, Rainer Ordemann   +8 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Cardiac Specific Gene Expression Changes in Long Term Culture of Murine Mesenchymal Stem Cells [PDF]

, 2011
Murine MSCs are a readily available source of adult stem cells enabling extensive in vitro study of this cell population. MSCs have been described as multipotent, and have been proven capable of differentiation into several connective tissue types ...
Whitelaw, B., Argyle, S.A., Hodgkiss-Geere, H.M., Bennett, D., Argyle, D.J., Corcoran, B.M., Milne, E.   +6 more
core  

Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis [PDF]

, 2012
Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide.
Aigner, Ludwig, Ludwig Aigner, Francisco J Rivera, Rivera, Francisco J   +3 more
core   +1 more source

Co-transplantation of Human Fetal Mesenchymal and Hematopoietic Stem Cells in Type 1 Diabetic Mice Model

Frontiers in Endocrinology, 2019
Introduction: Cell therapy can overcome the limitation of conventional treatments (including different medications and β cell replacement) for type 1 diabetes.
Babak Arjmand, Babak Arjmand, Parisa Goodarzi, Hamid Reza Aghayan, Moloud Payab, Fakher Rahim, Sepideh Alavi-Moghadam, Fereshteh Mohamadi-jahani, Bagher Larijani   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Mesenchymal stem cells as vectors for lung cancer therapy [PDF]

, 2013
Despite recent advances in treatment, lung cancer accounts for one third of all cancer-related deaths, underlining the need of development of new therapies.
Laurent, GJ, Janes, SM, Kolluri, KK
core