Results 71 to 80 of about 556,462 (362)

Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells

Haematologica, 2013
The melanoma cell adhesion molecule defines mesenchymal stromal cells in the human bone marrow that regenerate bone and establish a hematopoietic microenvironment in vivo.
Sabine Stopp, Martin Bornhäuser, Fernando Ugarte, Manja Wobus, Matthias Kuhn, Sebastian Brenner, Sebastian Thieme   +6 more
doaj   +1 more source

Hypoxic Culture Conditions as a Solution for Mesenchymal Stem Cell Based Regenerative Therapy [PDF]

, 2014
Cell-based regenerative therapies, based on in vitro propagation of stem cells, offer tremendous hope to many individuals suffering from degenerative diseases that were previously deemed untreatable.
Abu Kasim, N. H., Alabsi, A. M., Haque, N., Rahman, M. T.   +3 more
core   +1 more source

Mesenchymal stem cells: From stem cells to sarcomas [PDF]

Cell Biology International, 2016
Abstract Mesenchymal stem cells (MSCs) have garnered vast interests in clinical settings, especially in regenerative medicine due to their unique properties—they are reliably isolated and expanded from various tissue sources; they are able to differentiate into mesodermal tissues such as bones,
Lye, Kwan Liang, Nordin, Norshariza, Vidyadaran, Sharmili, Karuppiah, Thilakavathy   +3 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Identification of regulatory factors for mesenchymal stem cell-derived salivary epithelial cells in a co-culture system. [PDF]

PLoS ONE, 2014
Patients with Sjögren's syndrome or head and neck cancer patients who have undergone radiation therapy suffer from severe dry mouth (xerostomia) due to salivary exocrine cell death.
Yun-Jong Park, Jin Koh, Adrienne E Gauna, Sixue Chen, Seunghee Cha   +4 more
doaj   +1 more source

Odontogenic MSC Heterogeneity: Challenges and Opportunities for Regenerative Medicine

Frontiers in Physiology, 2022
Cellular heterogeneity refers to the genetic and phenotypic differences among cells, which reflect their various fate choices, including viability, proliferation, self-renewal probability, and differentiation into different lineages.
Yuan Chen, Zhaoyichun Zhang, Xiaoxue Yang, Anqi Liu, Shiyu Liu, Jianying Feng, Kun Xuan   +6 more
doaj   +1 more source

Mesenchymal Differentiation and Organ Distribution of Established Human Stromal Cell Lines in NOD/SCID Mice [PDF]

, 2001
Two human stromal cell lines were established previously from bone marrow-derived primary long-term cultures by immortalization using the SV40 large T antigen and cellular cloning. After irradiation, the fibroblast-like cell lines L87/4 and L88/5 support
Huss, Ralf, Meissner, Petra, Moosmann, Sabine, Sagebiel, Sabine, Thalmeier, Karin, Wiest, Irmgard   +5 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Introduce Characteristic, Types and Functional Mechanism of Adjuvants as a Biologic Complement [PDF]

Journal of Advanced Biomedical Sciences, 2019
The widespread use of effective vaccines against infectious diseases has been one of the most important public health progresses in the 21st century.
Tahereh Zarei Taher, Ali Kowsari, Mohsen Sheykhhasan, Hamed Manoochehri, Naser Kalhor, Leila Naserpour   +5 more
doaj  

Myogenic-induced mesenchymal stem cells are capable of modulating the immune response by regulatory T cells

Journal of Tissue Engineering, 2014
Cell therapy for patients who have intractable muscle disorders may require highly regenerative cells from young, healthy allogeneic donors. Mesenchymal stem cells are currently under clinical investigation because they are known to induce muscle ...
Sunyoung Joo, Hyun Ju Lim, John D Jackson, Anthony Atala, James J Yoo   +4 more
doaj   +1 more source