Results 51 to 60 of about 1,352,090 (296)

Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID-repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages

Haematologica, 2010
Background Bone marrow mesenchymal stem cells support proliferation and differentiation of hematopoietic progenitor cells in vitro. Since these cells constitute a rare subset of bone marrow cells, mesenchymal stem cell preparations for clinical purposes ...
Alexandra Briquet, Sophie Dubois, Sandrine Bekaert, Marie Dolhet, Yves Beguin, André Gothot   +5 more
doaj   +1 more source

GATA2 regulates differentiation of bone marrow-derived mesenchymal stem cells

Haematologica, 2014
The bone marrow microenvironment comprises multiple cell niches derived from bone marrow mesenchymal stem cells. However, the molecular mechanism of bone marrow mesenchymal stem cell differentiation is poorly understood. The transcription factor GATA2 is
Mayumi Kamata, Yoko Okitsu, Tohru Fujiwara, Masahiko Kanehira, Shinji Nakajima, Taro Takahashi, Ai Inoue, Noriko Fukuhara, Yasushi Onishi, Kenichi Ishizawa, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae   +12 more
doaj   +1 more source

Factors Affecting the Population of Mesenchymal Stem Cells in Adipose-Derived Stromal Vascular Fraction

Balkan Medical Journal, 2022
Background: Recently, the adipose tissue-derived stromal vascular fraction has become the most popular source for obtaining mesenchymal stem cells because it is less expensive and is easier to perform than bone marrow concentrate harvesting.
E. Çiğdem Karadağ Sarı, Ercüment Ovalı   +1 more
doaj   +1 more source

Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis. [PDF]

, 2015
Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits.
Biswas, Sangita, Deng, Wenbin, Qin, Xin, Xiao, Juan, Yang, Rongbing, Zhang, Min   +5 more
core   +3 more sources

Wnt-mediated endothelial transformation into mesenchymal stem cell–like cells induces chemoresistance in glioblastoma

Science Translational Medicine, 2020
Glioblastoma-associated endothelial cells transform into mesenchymal stem cell–like cells via Wnt/β-catenin, inducing tumor resistance to chemotherapy.
Menggui Huang, Duo Zhang, Janet Y. Wu, Kun Xing, Eujing Yeo, Chunsheng Li, Lin Zhang, E. Holland, L. Yao, L. Qin, Zev A. Binder, D. O’Rourke, S. Brem, C. Koumenis, Y. Gong, Yi Fan   +15 more
semanticscholar   +1 more source

Evaluation of Kohlrabi (Brassica oleracea Var. Gongylodes) Extract Effect on Mesenchymal Stem Cells Viability and Apoptosis

Research in Molecular Medicine, 2020
Background: Cell viability and apoptosis are two crucial factors that may determine cell fate. There are several factors, such as hypoxia, which may be effective in cell processes.
Naser Kalhor Qom, Mohsen Sheykhhasan, Ali Kowsari   +2 more
doaj  

The Late Osteoblast/Preosteocyte Cell Line MLO-A5 Displays Mesenchymal Lineage Plasticity In Vitro and In Vivo

Stem Cells International, 2019
The process of osteoblast switching to alternative mesenchymal phenotypes is incompletely understood. In this study, we tested the ability of the osteoblast/preosteocyte osteogenic cell line, MLO-A5, to also differentiate into either adipocytes or ...
Dongqing Yang, Stan Gronthos, Sandra Isenmann, Howard A. Morris, Gerald J. Atkins   +4 more
doaj   +1 more source

Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

Cells, 2019
Mesenchymal stem cell (MSC)-sourced secretome, defined as the set of MSC-derived bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed therapeutic effects similar to those observed after transplantation of MSCs ...
C. Harrell, Crissy Fellabaum, N. Jovicic, V. Djonov, N. Arsenijević, V. Volarevic   +5 more
semanticscholar   +1 more source

The emerging antioxidant paradigm of mesenchymal stem cell therapy

Stem Cells Translational Medicine, 2020
Mesenchymal stem cells (multipotent stromal cells; MSCs) have been under investigation for the treatment of diverse diseases, with many promising outcomes achieved in animal models and clinical trials.
Rhian Stavely, K. Nurgali
semanticscholar   +1 more source

Microvesicles as vehicles for tissue regeneration: Changing of the guards [PDF]

, 2016
Purpose of Review: Microvesicles (MVs) have been recognised as mediators of stem cell function, enabling and guiding their regenerative effects. Recent Findings: MVs constitute one unique size class of extracellular vesicles (EVs) directly shed from ...
Davies, R. Wayne, Panagiotou, Nikolaos, Selman, Colin, Shiels, Paul G.   +3 more
core   +1 more source