Results 61 to 70 of about 561,805 (383)

L-Proline Induces a Mesenchymal-like Invasive Program in Embryonic Stem Cells by Remodeling H3K9 and H3K36 Methylation [PDF]

, 2013
SummaryMetabolites are emerging as key mediators of crosstalk between metabolic flux, cellular signaling, and epigenetic regulation of cell fate. We found that the nonessential amino acid L-proline (L-Pro) acts as a signaling molecule that promotes the ...
Angelini, Claudia, Cimmino, Amelia, Comes, Stefania, De Cesare, Dario, De Falco, Sandro, Fico, Annalisa, Gagliardi, Miriam, Laprano, Nicola, Matarazzo, Maria R., Minchiotti, Gabriella, Palamidessi, Andrea, Patriarca, Eduardo J., Scita, Giorgio   +12 more
core   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Co-transplantation of Human Fetal Mesenchymal and Hematopoietic Stem Cells in Type 1 Diabetic Mice Model

Frontiers in Endocrinology, 2019
Introduction: Cell therapy can overcome the limitation of conventional treatments (including different medications and β cell replacement) for type 1 diabetes.
Babak Arjmand, Babak Arjmand, Parisa Goodarzi, Hamid Reza Aghayan, Moloud Payab, Fakher Rahim, Sepideh Alavi-Moghadam, Fereshteh Mohamadi-jahani, Bagher Larijani   +8 more
doaj   +1 more source

Cholangiocytes: Cell transplantation [PDF]

, 2017
Background:Due to significant limitations to the access to orthotropic liver transplantation, cell therapies forliver diseases have gained large interest worldwide.Scope of review:To revise current literature dealing with cell therapy for liver diseases.
Alvaro, Domenico, Bragazzi, MARIA CONSIGLIA, Cardinale, Vincenzo, Carpino, Guido, Gaudio, Eugenio, Ridola, Lorenzo   +5 more
core   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modeling the niche compartments in vitro

Haematologica, 2010
Background Hematopoietic stem cells located in the bone marrow interact with a specific microenvironment referred to as the stem cell niche. Data derived from ex vivo co-culture systems using mesenchymal stromal cells as a feeder cell layer suggest that ...
Duohui Jing, Ana-Violeta Fonseca, Nael Alakel, Fernando A. Fierro, Katrin Muller, Martin Bornhauser, Gerhard Ehninger, Denis Corbeil, Rainer Ordemann   +8 more
doaj   +1 more source

Use of mesenchymal stem cell therapy in COVID-19 related strokes

Neural Regeneration Research, 2023
Coronavirus disease 2019 (COVID-19) has affected a broad demographics, eliciting a more significant effect on specific groups such as males, African Americans, and Hispanic minorities.
Mahika Rawat, Chiao Ng, Emaad Khan, Rayyan A Shah, Suha Ashfaq, Ghaith A Bahader, Zahoor A Shah   +6 more
doaj   +1 more source

CARS and SHG microscopy to follow the collagen production in living human corneal fibroblasts and mesenchymal stem cells in fibrin gel 3D cultures [PDF]

, 2011
Coherent anti-Stokes Raman scattering (CARS) microscopy is combined with second harmonic generation (SHG) technique in order to follow the early stage of stem cell differentiation within a 3D scaffold. CARS microscopy can detect lipid membranes and droplet compartments in living cells and SHG microscopy enables a strong imaging contrast for molecules ...
arxiv   +1 more source

Numerical analysis of a mechanotransduction dynamical model reveals homoclinic bifurcations of extracellular matrix mediated oscillations of the mesenchymal stem cell fate [PDF]

International Journal of Non-Linear Mechanics, 113, 146-157, 2019, 2019
We perform one and two-parameter numerical bifurcation analysis of a mechanotransduction model approximating the dynamics of mesenchymal stem cell differentiation into neurons, adipocytes, myocytes and osteoblasts. For our analysis, we use as bifurcation parameters the stiffness of the extracellular matrix and parameters linked with the positive ...
arxiv   +1 more source

Morphology and size of stem cells from mouse and whale: Observational study [PDF]

, 2013
Objective To compare the morphology and size of stem cells from two mammals of noticeably different body size. Design Observational study. Setting The Netherlands.
Beukel, J.C. (Anneke) van den, Hoogduijn, M.J. (Martin), Ijzer, J. (Jooske), Wiersma, L.C.M. (Lidewij)   +3 more
core   +1 more source