Results 61 to 70 of about 1,146,077 (364)

Identification of regulatory factors for mesenchymal stem cell-derived salivary epithelial cells in a co-culture system. [PDF]

PLoS ONE, 2014
Patients with Sjögren's syndrome or head and neck cancer patients who have undergone radiation therapy suffer from severe dry mouth (xerostomia) due to salivary exocrine cell death.
Yun-Jong Park, Jin Koh, Adrienne E Gauna, Sixue Chen, Seunghee Cha   +4 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches

Frontiers in Medicine
The inability to get or sustain an erection strong enough for fulfilling sexual performance is the hallmark of the common disorder known as erectile dysfunction (ED). It mostly affects a significant percentage of men worldwide, particularly those aged 40
Xiaoliang Fu, Azar Sheikholeslami, Ulanbek Zhanbyrbekuly, Faezeh Davoodi Asl, Nadiar M. Mussin, Hoda Fazaeli, Karim Daniyalov, Nader Tanideh, Nader Tanideh, Nader Tanideh, Mahdi Mahdipour, Mahdi Mahdipour, Madina A. Kurmanalina, Amin Tamadon, Amin Tamadon, Amin Tamadon   +15 more
doaj   +1 more source

Myogenic-induced mesenchymal stem cells are capable of modulating the immune response by regulatory T cells

Journal of Tissue Engineering, 2014
Cell therapy for patients who have intractable muscle disorders may require highly regenerative cells from young, healthy allogeneic donors. Mesenchymal stem cells are currently under clinical investigation because they are known to induce muscle ...
Sunyoung Joo, Hyun Ju Lim, John D Jackson, Anthony Atala, James J Yoo   +4 more
doaj   +1 more source

Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modeling the niche compartments in vitro

Haematologica, 2010
Background Hematopoietic stem cells located in the bone marrow interact with a specific microenvironment referred to as the stem cell niche. Data derived from ex vivo co-culture systems using mesenchymal stromal cells as a feeder cell layer suggest that ...
Duohui Jing, Ana-Violeta Fonseca, Nael Alakel, Fernando A. Fierro, Katrin Muller, Martin Bornhauser, Gerhard Ehninger, Denis Corbeil, Rainer Ordemann   +8 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Preconditioning influences mesenchymal stem cell properties in vitro and in vivo

Journal of Cellular and Molecular Medicine, 2018
Various diseases and toxic factors easily impair cellular and organic functions in mammals. Organ transplantation is used to rescue organ function, but is limited by scarce resources.
Chenxia Hu, Lanjuan Li
semanticscholar   +1 more source

Mesenchymal stem cells in hematopoietic stem cell transplantation [PDF]

Cytotherapy, 2009
Mesenchymal stromal/stem cells (MSC) of bone marrow (BM) origin not only provide the supportive microenvironmental niche for hematopoietic stem cells (HSC) but are capable of differentiating into various cell types of mesenchymal origin, such as bone, fat and cartilage.
Minoo, Battiwalla, Peiman, Hematti
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Odontogenic MSC Heterogeneity: Challenges and Opportunities for Regenerative Medicine

Frontiers in Physiology, 2022
Cellular heterogeneity refers to the genetic and phenotypic differences among cells, which reflect their various fate choices, including viability, proliferation, self-renewal probability, and differentiation into different lineages.
Yuan Chen, Zhaoyichun Zhang, Xiaoxue Yang, Anqi Liu, Shiyu Liu, Jianying Feng, Kun Xuan   +6 more
doaj   +1 more source