Results 41 to 50 of about 79,337 (314)
Mesenchymal stem cell transplantation in multiple sclerosis [PDF]
Journal of the Neurological Sciences, 2013 Mesenchymal stem cells (MSCs) are pluripotent non-hematopoietic precursor cells that can be isolated from bone marrow and numerous other tissues, culture-expanded to purity, and induced to differentiate in vitro and in vivo into mesodermal derivatives. MSCs exhibit many phenotypic and functional similarities to pericytes.
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Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice [PDF]
Yearbook of Paediatric Endocrinology, 2018 Spermatogonial stem cell transplantation (SSCT) could become a fertility restoration tool for childhood cancer survivors. However, since in mice, the colonization efficiency of transplanted spermatogonial stem cells (SSCs) is only 12%, the efficiency of the procedure needs to be improved before clinical implementation is possible. Co-transplantation of
Kadam, Prashant +5 more
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Advances in mesenchymal stem cell transplantation for the treatment of osteoporosis [PDF]
Cell Proliferation, 2020 AbstractOsteoporosis is a systemic metabolic bone disease with characteristics of bone loss and microstructural degeneration. The personal and societal costs of osteoporosis are increasing year by year as the ageing of population, posing challenges to public health care. Homing disorders, impaired capability of osteogenic differentiation, senescence of
Yuhe Jiang +4 more
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Neural Regeneration Research, 2016 We hypothesized that a chemically extracted acellular allogeneic nerve graft used in combination with bone marrow mesenchymal stem cell transplantation would be an effective treatment for long-segment sciatic nerve defects.
Ya-jun Li +4 more
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Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke [PDF]
Cell Transplantation, 2018 Stroke is a major disease that leads to high mortality and morbidity. Given the ageing population and the potential risk factors, the prevalence of stroke and socioeconomic burden associated with stroke are expected to increase. During the past decade, both prophylactic and therapeutic strategies for stroke have made significant progress.
Fan Wang +3 more
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Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
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Parkinson's Disease and Mesenchymal Stem Cells: Potential for Cell-Based Therapy
Parkinson's Disease, 2012 Cell transplantation is a strategy with great potential for the treatment of Parkinson's disease, and many types of stem cells, including neural stem cells and embryonic stem cells, are considered candidates for transplantation therapy.
Masaaki Kitada, Mari Dezawa
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Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice
Journal of Neuroinflammation, 2018 Background Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that mesenchymal stem cell therapy protected blood-brain barrier disruption from several ...
Zhuo Cheng +8 more
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Dose-Independent Therapeutic Benefit of Bone Marrow Stem Cell Transplantation after MI in Mice
Biomedicines, 2020 Several cell populations derived from bone marrow (BM) have been shown to possess cardiac regenerative potential. Among these are freshly isolated CD133+ hematopoietic as well as culture-expanded mesenchymal stem cells. Alternatively, by purifying CD271+
Nicole Zarniko +4 more
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Mesenchymal stem cell transplantation to promote bone healing [PDF]
Journal of Orthopaedic Research, 2012 AbstractAn overall decline in the availability of osteogenic precursor cells and growth factors in the bone marrow microenvironment have been associated with impaired bone formation and osteopenia in humans. The objective of the current study was to determine if transplantation of mesenchymal stromal cells (MSC) from a healthy, young donor mouse into ...
Nicolas Tran-Khanh +9 more
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