Results 61 to 70 of about 5,762,651 (303)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Mesenchymal Stem Cells as Immunomodulators in Transplantation [PDF]
, 2012 In recent years it has become evident that mesenchymal stem cells (MSCs), also termed mesenchymal stromal cells, have potent immunomodulatory effects in addition to their known ability of organ regeneration and recruitment to sites of injured or inflamed tissue (Caplan 1991; Garin, Chu et al. 2007; Nauta and Fibbe 2007; Bianco, Robey et al.
Nadia Zghoul +2 more
openaire +1 more source
The in vitro plasticity of hair follicle dermal and mesenchymal stem cells [PDF]
, 2008 Stem cells from the hair follicle are an easily accessible population of cells that have a broad in vitro developmental capabilities and potential for autologous replacement of damaged adult tissue.
Emmerson, Robert
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2011 Mesenchymal stem cells are multipotent stromal cells residing within the connective tissue of most organs. Their surface phenotype has been well described.
Grange, Simon
core +1 more source
Progress in mesenchymal stem cell–based therapy for acute liver failure
Stem Cell Research & Therapy, 2018 Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. Numerous treatment strategies for acute liver failure simply prevent complications and
Yong-Hong Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Transplantation of human umbilical cord mesenchymal stem cells to treat premature ovarian failure
Stem Cell Research & Therapy, 2021 As one of the problems and diseases for women before 40 years, premature ovarian failure (POF) could be characterized by amenorrhea, low estrogen levels, infertility, high gonadotropin levels, and lack of mature follicles.
Oldouz Shareghi-oskoue +2 more
doaj +1 more source
Investigations into the in vitro developmental plasticity of adult mesenchymal stem cells [PDF]
, 2006 Bone marrow (BM) derived stem cells contribute to the regeneration of diverse adult tissues including heart, liver and brain following BM transplantation.
Croft, Adam P., Croft, Adam P
core
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source