Results 41 to 50 of about 421,152 (353)

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. [PDF]

, 2012
BACKGROUND: More than half of patients with multiple sclerosis have progressive disease characterised by accumulating disability. The absence of treatments for progressive multiple sclerosis represents a major unmet clinical need.
Kolappan, Madhan, Thompson, Alan J, Luan, Shi-Lu, Altmann, Daniel R, Crawley, Charles, Compston, Alastair, Patani, Rickie, Scott, Michael A, Du, Ming-Qing, Miller, David H, Michell, Andrew W, Chandran, Siddharthan, Connick, Peter, Webber, Daniel J   +13 more
core   +1 more source

Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation

Neural Regeneration Research, 2015
We examined the restorative effect of modified biodegradable chitin conduits in combination with bone marrow mesenchymal stem cell transplantation after right spinal cord hemisection injury.
Feng Xue, Er-jun Wu, Pei-xun Zhang, Li-ya A, Yu-hui Kou, Xiao-feng Yin, Na Han   +6 more
doaj   +1 more source

Autologous mesenchymal stem cell transplantation in stroke patients

Annals of Neurology, 2005
Mesenchymal stem cell (MSC) transplantation improves recovery from ischemic stroke in animals. We examined the feasibility, efficacy, and safety of cell therapy using culture‐expanded autologous MSCs in patients with ischemic stroke. We prospectively and
Oh Young Bang, Jin Soo Lee, Phil Hyu Lee, Gwang Lee   +3 more
semanticscholar   +1 more source

Mesenchymal stem cell transplantation to promote bone healing [PDF]

Journal of Orthopaedic Research, 2012
AbstractAn overall decline in the availability of osteogenic precursor cells and growth factors in the bone marrow microenvironment have been associated with impaired bone formation and osteopenia in humans. The objective of the current study was to determine if transplantation of mesenchymal stromal cells (MSC) from a healthy, young donor mouse into ...
Chan, Gao, Jan, Seuntjens, Gabriel N, Kaufman, Nicolas, Tran-Khanh, Alison, Butler, Ailian, Li, Huifen, Wang, Michael D, Buschmann, Edward J, Harvey, Janet E, Henderson   +9 more
openaire   +2 more sources

Alginate Scaffolds for Mesenchymal Stem Cell Cardiac Therapy: Influence of Alginate Composition [PDF]

, 2012
Despite the success of alginate scaffolds and mesenchymal stem cells (MSCs) therapy in cardiac failure treatment, the impact of the physicochemical environment provided by alginate matrices on cell behavior has never been investigated.
Alfarano, Chiara, Ceccaldi, Caroline, Calise, Denis, Sallerin, Brigitte, Girod Fullana, Sophie, Cussac, Daniel, Parini, Angelo, Lairez, Olivier   +7 more
core   +1 more source

Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis

Cell Research, 2017
Systemic sclerosis (SSc), an autoimmune disease, may cause significant osteopenia due to activation of the IL4Rα/mTOR pathway. Mesenchymal stem cell transplantation (MSCT) can ameliorate immune disorders in SSc via inducing immune tolerance.
Chider Chen, Dandan Wang, A. Moshaverinia, Dawei Liu, X. Kou, Wenjing Yu, Ruili Yang, Lingyun Sun, S. Shi   +8 more
semanticscholar   +1 more source

Mesenchymal stem cells for inducing tolerance in organ transplantation [PDF]

Frontiers in Cell and Developmental Biology, 2014
Organ transplantation is useful for treating the end stage of organ failure. The induction of tolerance to the transplanted organ is essential for its long-term survival. Immunologic tolerance can be induced by immunosuppressive agents and mixed chimerism.
Guo, Kequan, Ikehara, Susumu, Meng, Xu
openaire   +3 more sources

Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells: lumican null mice.

PLoS ONE, 2010
BackgroundKeratoplasty is the most effective treatment for corneal blindness, but suboptimal medical conditions and lack of qualified medical personnel and donated cornea often prevent the performance of corneal transplantation in developing countries ...
Hongshan Liu, Jianhua Zhang, Chia-Yang Liu, I-Jong Wang, Martin Sieber, John Chang, James V Jester, Winston W Y Kao   +7 more
doaj   +1 more source

Mesenchymal Stem Cells for the Treatment of Liver Disease: Present and Perspectives

Gut and Liver, 2020
Mesenchymal stem cell transplantation is an emerging therapy for treating chronic liver diseases. The potential of this treatment has been evaluated in preclinical and clinical studies. Although the mechanisms of mesenchymal stem cell transplantation are
Seong Hee Kang, Moon Young Kim, Young Woo Eom, Soon Koo Baik   +3 more
doaj   +1 more source

Stem Cell Transplantation in the Treatment of Type 1 Diabetes Mellitus: From Insulin Replacement to Beta-Cell Replacement

Frontiers in Endocrinology, 2022
Type 1 diabetes mellitus (T1DM) is an autoimmune disease that attacks pancreatic β-cells, leading to the destruction of insulitis-related islet β-cells. Islet β-cell transplantation has been proven as a curative measure in T1DM.
Xin-Xing Wan, Dan-Yi Zhang, Md. Asaduzzaman Khan, Sheng-Yuan Zheng, Xi-Min Hu, Qi Zhang, Rong-Hua Yang, Kun Xiong, Kun Xiong, Kun Xiong   +9 more
doaj   +1 more source