Results 51 to 60 of about 5,762,651 (303)

Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice

Journal of Neuroinflammation, 2018
Background Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that mesenchymal stem cell therapy protected blood-brain barrier disruption from several ...
Zhuo Cheng, Liping Wang, Meijie Qu, Huaibin Liang, Wanlu Li, Yongfang Li, Lidong Deng, Zhijun Zhang, Guo-Yuan Yang   +8 more
doaj   +1 more source

Adipose-derived mesenchymal stromal/stem cells : tissue localization, characterization, and heterogeneity [PDF]

, 2012
Adipose tissue as a stem cell source is ubiquitously available and has several advantages compared to other sources. It is easily accessible in large quantities with minimal invasive harvesting procedure, and isolation of adipose-derived mesenchymal ...
Helmut Geiger, Geiger, Helmut, Baer, Patrick C., Patrick C. Baer   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Parkinson's Disease and Mesenchymal Stem Cells: Potential for Cell-Based Therapy

Parkinson's Disease, 2012
Cell transplantation is a strategy with great potential for the treatment of Parkinson's disease, and many types of stem cells, including neural stem cells and embryonic stem cells, are considered candidates for transplantation therapy.
Masaaki Kitada, Mari Dezawa
doaj   +1 more source

Acellular allogeneic nerve grafting combined with bone marrow mesenchymal stem cell transplantation for the repair of long-segment sciatic nerve defects: biomechanics and validation of mathematical models

Neural Regeneration Research, 2016
We hypothesized that a chemically extracted acellular allogeneic nerve graft used in combination with bone marrow mesenchymal stem cell transplantation would be an effective treatment for long-segment sciatic nerve defects.
Ya-jun Li, Bao-lin Zhao, Hao-ze Lv, Zhi-gang Qin, Min Luo   +4 more
doaj   +1 more source

Ontological Differences in First Compared to Third Trimester Human Fetal Placental Chorionic Stem Cells [PDF]

, 2012
Human mesenchymal stromal/stem cells (MSC) isolated from fetal tissues hold promise for use in tissue engineering applications and cell-based therapies, but their collection is restricted ethically and technically.
Vanleene, Maximilien, George Bou-Gharios (139817), Moschidou Dafni, Gemma N Jones, Maximilien Vanleene (139811), George Bou-Gharios, Puga-Iglesias, Tamara-Isabel, Katarzyna Kuleszewicz, Sandra J. Shefelbine (139814), David, AL, Shefelbine, Sandra J., Fisk, NM, David Anna L., Moschidou, Dafni, Shefelbine Sandra J., Guillot, Pascale V., Bou-Gharios George, Gemma N. Jones (139797), Maximilien Vanleene, Fisk Nicholas M., Nicholas M Fisk, Shefelbine, SJ, De Coppi, Paolo, Puga-Iglesias, TI, Puga-Iglesias Tamara-Isabel, Katarzyna Kuleszewicz (139808), Paolo De Coppi (118582), Jones Gemma N., Bou-Gharios, G, Pascale V. Guillot (139827), Kuleszewicz Katarzyna, Anna L David, Vanleene, M, Kuleszewicz, K, David, Anna L., Sandra J Shefelbine, Fisk, Nicholas M., Dafni Moschidou, Paolo De Coppi, Bou-Gharios, George, Tamara-Isabel Puga-Iglesias, Pascale V Guillot, Jones, GN, Tamara-Isabel Puga-Iglesias (139805), Guillot, PV, De Coppi Paolo, Fisk, NM ; https://orcid.org/, Jones, Gemma N., Dafni Moschidou (139801), Guillot Pascale V., Kuleszewicz, Katarzyna, Moschidou, D, Vanleene Maximilien, Nicholas M. Fisk (139820), De Coppi, P, Anna L. David (139823)   +55 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Dose-Independent Therapeutic Benefit of Bone Marrow Stem Cell Transplantation after MI in Mice

Biomedicines, 2020
Several cell populations derived from bone marrow (BM) have been shown to possess cardiac regenerative potential. Among these are freshly isolated CD133+ hematopoietic as well as culture-expanded mesenchymal stem cells. Alternatively, by purifying CD271+
Nicole Zarniko, Anna Skorska, Gustav Steinhoff, Robert David, Ralf Gaebel   +4 more
doaj   +1 more source

The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments. [PDF]

, 2011
BACKGROUND: No treatments are currently available that slow, stop, or reverse disease progression in established multiple sclerosis (MS). The Mesenchymal Stem Cells in Multiple Sclerosis (MSCIMS) trial tests the safety and feasibility of treatment with a
Kolappan, Madhan, Thomas, David L, Andrew W Michell, Altmann, Daniel R., Richardson, Karen, Wheeler-Kingshott, Claudia AM, Karen Richardson, Thompson, Alan J., Shi L Luan, David L Thomas, Tozer, Daniel J, Webber, Daniel J., Rebecca S Samson, Siddharthan Chandran, Xiao-Ling He, Crawley, Charles, Compston, Alastair, Du, Ming-Qing, Alan J Thompson, Michell, Andrew W, Webber, Daniel J, Peter Connick, Kelly Barber, Barber, Kelly, Ming-Qing Du, Thompson, Alan J, Michael A Scott, Claudia AM Wheeler-Kingshott, Charles Crawley, Madhan Kolappan, Alastair Compston, Thomas, David L., Patani, Rickie, Wheeler-Kingshott, Claudia A. M., Tozer, Daniel J., Miller, David H, Scott, Michael A., Daniel J Tozer, He, Xiao-Ling, Miller, David H., Luan, Shi L, Daniel J Webber, Rickie Patani, Altmann, Daniel R, Samson, Rebecca S, David H Miller, Scott, Michael A, Chandran, Siddharthan, Luan, Shi L., Daniel R Altmann, Connick, Peter, Samson, Rebecca S., Michell, Andrew W., Chandran Siddharthan, Kolappan Madhan, Luan Shi L, Miller David H, Crawley Charles, Richardson Karen, Wheeler-Kingshott Claudia AM, Scott Michael A, Thompson Alan J, Webber Daniel J, Du Ming-Qing, Compston Alastair, Patani Rickie, Altmann Daniel R, Samson Rebecca S, He Xiao-Ling, Connick Peter, Tozer Daniel J, Michell Andrew W, Barber Kelly, Thomas David L   +73 more
core   +4 more sources