Results 41 to 50 of about 90,123 (258)

MSX2 Initiates and Accelerates Mesenchymal Stem/Stromal Cell Specification of hPSCs by Regulating TWIST1 and PRAME

Stem Cell Reports, 2018
Summary: The gap in knowledge of the molecular mechanisms underlying differentiation of human pluripotent stem cells (hPSCs) into the mesenchymal cell lineages hinders the application of hPSCs for cell-based therapy.
Leisheng Zhang, Hongtao Wang, Cuicui Liu, Qingqing Wu, Pei Su, Dan Wu, Jiaojiao Guo, Wen Zhou, Yuanfu Xu, Lihong Shi, Jiaxi Zhou   +10 more
doaj   +1 more source

Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials

Stem Cell Research & Therapy, 2023
AbstractMesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their robust immunomodulatory and regenerative properties. Their paracrine activity is one of the most important features that contribute to their efficacy. Recently, it has been demonstrated that the production of various factors via extracellular vesicles ...
Ahmed Lotfy, Noha M. AboQuella, Hongjun Wang   +2 more
openaire   +3 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The differentiation potential of adipose tissue-derived mesenchymal stem cells into cell lineage related to male germ cells

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
The adipose tissue is a reliable source of Mesenchymal stem cells (MSCs) showing a higher plasticity and transdifferentiation potential into multilineage cells.
P. Bräunig, W.G. Glanzner, V.B. Rissi, P.B.D. Gonçalves   +3 more
doaj   +1 more source

The delivery of hsa-miR-11401 by extracellular vesicles can relieve doxorubicin-induced mesenchymal stem cell apoptosis

Stem Cell Research & Therapy, 2021
Background Chemotherapy is an effective anti-tumor treatment. Mesenchymal stem cells (MSCs), exerting therapy effect on injured tissues during chemotherapy, may be damaged in the process.
Huifang Li, Haoyan Huang, Xiaoniao Chen, Shang Chen, Lu Yu, Chen Wang, Yue Liu, Kaiyue Zhang, Lingling Wu, Zhong-Chao Han, Na Liu, Jie Wu, Zongjin Li   +12 more
doaj   +1 more source

Mesenchymal Stem Cells Derived from Human Periapical Cysts and Their Implications in Regenerative Medicine

Biomedicines, 2023
Mesenchymal stem cells currently play an important role in the tissue engineering field in developing new regenerative approaches. The oral cavity is a rich source of mesenchymal stem cells, and introducing the use of dental stem cells, characterized by ...
Alexandra Roi, Ciprian Roi, Meda Lavinia Negruțiu, Laura Cristina Rusu, Mircea Riviș   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Mesenchymal stem cells (MSCs) as skeletal therapeutics-an update:Journal of Biomedical Science [PDF]

Journal of Biomedical Science, 2016
Mesenchymal stem cells hold the promise to treat not only several congenital and acquired bone degenerative diseases but also to repair and regenerate morbid bone tissues. Utilizing MSCs, several lines of evidences advocate promising clinical outcomes in skeletal diseases and skeletal tissue repair/regeneration.
Saeed, H., Ahsan, M., Saleem, Z., Iqtedar, M., Islam, M A, Danish, Z., Khan, A. M.   +6 more
openaire   +1 more source

Endothelial Progenitor Cells (EPCs) and Mesenchymal Stem Cells (MSCs) in Bone Healing

Current Stem Cell Research & Therapy, 2012
Fracture healing is a complex physiological process. Local vascularity at the site of the fracture has been established as one of the most important factors influencing the healing process, and lack of vascularity has been implicated in atrophic non unions. Existing research has primarily involved utilising Mesenchymal Stem Cells (MSCs) to augment bone
Keramaris NC, Kaptanis S, Moss HL, Loppini M, Pneumaticos S, MAFFULLI, Nicola   +5 more
openaire   +5 more sources

Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer [PDF]

Oncotarget, 2012
Circulating bone marrow-derived Mesenchymal Stem Cells (BM-MSCs) have an innate tropism for tumor tissue in response to the inflammatory microenvironment present in malignant lesions. The prostate is bombarded by numerous infectious and inflammatory insults over a lifetime.
W Nathaniel, Brennen, Shuangling, Chen, Samuel R, Denmeade, John T, Isaacs   +3 more
openaire   +2 more sources