Results 41 to 50 of about 93,052 (258)

MSX2 Initiates and Accelerates Mesenchymal Stem/Stromal Cell Specification of hPSCs by Regulating TWIST1 and PRAME

Stem Cell Reports, 2018
Summary: The gap in knowledge of the molecular mechanisms underlying differentiation of human pluripotent stem cells (hPSCs) into the mesenchymal cell lineages hinders the application of hPSCs for cell-based therapy.
Leisheng Zhang, Hongtao Wang, Cuicui Liu, Qingqing Wu, Pei Su, Dan Wu, Jiaojiao Guo, Wen Zhou, Yuanfu Xu, Lihong Shi, Jiaxi Zhou   +10 more
doaj   +1 more source

Chorion-derived perinatal mesenchymal stem cells improve cardiac function and vascular regeneration: Preferential treatment for ischemic heart disease

Hellenic Journal of Cardiology, 2022
Background: Stem cell therapy has emerged as a novel treatment for heart failure after myocardial infarction (Ml). Bone marrow-derived mesenchymal stem cells (BM-MSCs) are commonly considered because of their accessibility and usability.
Yong Soo Park, Bong-Woo Park, Hayoung Choi, Seung Hee Lee, Myungshin Kim, Hun-Jun Park, In-Beom Kim   +6 more
doaj   +1 more source

Mesenchymal Stem Cells Derived from Human Periapical Cysts and Their Implications in Regenerative Medicine

Biomedicines, 2023
Mesenchymal stem cells currently play an important role in the tissue engineering field in developing new regenerative approaches. The oral cavity is a rich source of mesenchymal stem cells, and introducing the use of dental stem cells, characterized by ...
Alexandra Roi, Ciprian Roi, Meda Lavinia Negruțiu, Laura Cristina Rusu, Mircea Riviș   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The differentiation potential of adipose tissue-derived mesenchymal stem cells into cell lineage related to male germ cells

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
The adipose tissue is a reliable source of Mesenchymal stem cells (MSCs) showing a higher plasticity and transdifferentiation potential into multilineage cells.
P. Bräunig, W.G. Glanzner, V.B. Rissi, P.B.D. Gonçalves   +3 more
doaj   +1 more source

TGF-β Inhibitor SB431542 Promotes the Differentiation of Induced Pluripotent Stem Cells and Embryonic Stem Cells into Mesenchymal-Like Cells

Stem Cells International, 2018
Due to their potential for tissue engineering applications and ability to modulate the immune system and reduce inflammation, mesenchymal stem cells (MSCs) have been explored as a promising option for the treatment of chronic diseases and injuries ...
Alessander Leyendecker Junior
doaj   +1 more source

The delivery of hsa-miR-11401 by extracellular vesicles can relieve doxorubicin-induced mesenchymal stem cell apoptosis

Stem Cell Research & Therapy, 2021
Background Chemotherapy is an effective anti-tumor treatment. Mesenchymal stem cells (MSCs), exerting therapy effect on injured tissues during chemotherapy, may be damaged in the process.
Huifang Li, Haoyan Huang, Xiaoniao Chen, Shang Chen, Lu Yu, Chen Wang, Yue Liu, Kaiyue Zhang, Lingling Wu, Zhong-Chao Han, Na Liu, Jie Wu, Zongjin Li   +12 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Mesenchymal stem cells (MSCs) as skeletal therapeutics-an update:Journal of Biomedical Science [PDF]

Journal of Biomedical Science, 2016
Mesenchymal stem cells hold the promise to treat not only several congenital and acquired bone degenerative diseases but also to repair and regenerate morbid bone tissues. Utilizing MSCs, several lines of evidences advocate promising clinical outcomes in skeletal diseases and skeletal tissue repair/regeneration.
Saeed, H., Ahsan, M., Saleem, Z., Iqtedar, M., Islam, M A, Danish, Z., Khan, A. M.   +6 more
openaire   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source