Results 61 to 70 of about 93,052 (258)

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

Identification and Characterization of Human Endometrial Mesenchymal Stem/Stromal Cells and Their Potential for Cellular Therapy

Stem Cells Translational Medicine, 2016
Summary Human endometrium is a highly regenerative tissue, undergoing more than 400 cycles of proliferation, differentiation, and shedding during a woman's reproductive life.
Saeedeh Darzi, Jerome A. Werkmeister, James A. Deane, Caroline E. Gargett   +3 more
doaj   +1 more source

Roles of Mesenchymal Stem Cells (MSCs) in bacterial diseases

Journal of Biomedical Research, 2013
Mesenchymal stem cell (MSC) based cell therapy has emerged as a promising therapeutic approach for treatment of several degenerative, infectious and non-infectious diseases. Numerous studies have demonstrated the remarkable immunosuppressive and antibacterial effects of MSCs both in vitro and in vivo, in animal models and in humans.
nuclePalaksha K Javaregowda, Jang Won Yoon, Goo Jang   +2 more
openaire   +1 more source

Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials

Stem Cell Research & Therapy, 2023
AbstractMesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their robust immunomodulatory and regenerative properties. Their paracrine activity is one of the most important features that contribute to their efficacy. Recently, it has been demonstrated that the production of various factors via extracellular vesicles ...
Ahmed Lotfy, Noha M. AboQuella, Hongjun Wang   +2 more
openaire   +3 more sources

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Mesenchymal stem cells preserve their stem cell traits after exposure to antimetabolite chemotherapy

Stem Cell Research, 2019
Background: Mesenchymal stem cells (MSCs) participate in the regeneration of tissue lesions induced by antimetabolite chemotherapy; however, the influence of this class of anti-cancer compounds on the stem cells remains largely unknown.
Ramon Lopez Perez, Franziska Münz, Denise Vidoni, Alexander Rühle, Thuy Trinh, Sonevisay Sisombath, Bingwen Zou, Patrick Wuchter, Jürgen Debus, Anca-Ligia Grosu, Rainer Saffrich, Peter E. Huber, Nils H. Nicolay   +12 more
doaj   +1 more source

Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer [PDF]

Oncotarget, 2012
Circulating bone marrow-derived Mesenchymal Stem Cells (BM-MSCs) have an innate tropism for tumor tissue in response to the inflammatory microenvironment present in malignant lesions. The prostate is bombarded by numerous infectious and inflammatory insults over a lifetime.
W Nathaniel, Brennen, Shuangling, Chen, Samuel R, Denmeade, John T, Isaacs   +3 more
openaire   +2 more sources

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Advanced Healthcare Materials, EarlyView.
Recent advances in microfluidic technologies for microgel fabrication are critically reviewed, highlighting the capabilities and limitations of major microfluidic platforms and discussing how platform design, material selection, and crosslinking strategies influence microgel architecture and functionality. Current challenges and future opportunities in
Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios‐Cervantes, Ben A. Kertesz, Todd Hoare   +6 more
wiley   +1 more source

Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications

Dentistry Journal, 2018
Tissue engineering is based on the interaction between stem cells, biomaterials and factors delivered in biological niches. Oral tissues have been found to be rich in stem cells from different sources: Stem cells from oral cavity are easily harvestable ...
Gianrico Spagnuolo, Bruna Codispoti, Massimo Marrelli, Carlo Rengo, Sandro Rengo, Marco Tatullo   +5 more
doaj   +1 more source

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

Advanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick, Salim El Hadwe, Kesi Liang, George G. Malliaras, Damiano G. Barone   +4 more
wiley   +1 more source