Results 191 to 200 of about 143,813 (266)

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Rejuvenation of mesenchymal stromal cells via partial reprogramming enables scalable generation of transcriptionally diverse MSC libraries. [PDF]

Stem Cell Res Ther
Tu H, Hosaka A, Hichiwa G, Wang Y, Kazuki K, Tabata T, Osaki M, Nakayama Y, Kanazawa I, Honma K, Kimura MT, Gao X, Ogata N, Abe S, Oshimura M, Kazuki Y.   +15 more
europepmc   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

RGD-modified alginate enhances viability, metabolic reprogramming, and cytokine secretion profiles in encapsulated mesenchymal stromal cells. [PDF]

Sci Rep
Güven K, Dhawan A, Filippi C.
europepmc   +1 more source

Mass culture of equine synovial fluid‐derived mesenchymal stromal cells using nonwoven polyethylene terephthalate fabrics

Equine Veterinary Journal, EarlyView.
Abstract Background Culture protocols need to yield 100 million equine synovial fluid (SF)‐derived mesenchymal stromal cells (SF‐MSCs) in around 3 weeks are needed, before these cells can be evaluated as agents of articular repair in clinical trials. Objectives To investigate mass culture of equine SF‐MSC culture protocols using nonwoven polyethylene ...
Miho Daniel Yoshitomi, Tomohide Kuramoto, Takashi Hatazoe, Kenta Mitsuda, Henry Smith, Kazuhiro Misumi   +5 more
wiley   +1 more source

Immunomodulatory Mechanisms of Mesenchymal Stromal Cells: Cytokine Networks and Therapeutic Potential Across Immune-Mediated, Inflammatory, and Regenerative Disorders. [PDF]

Biology (Basel)
Nurlybek T, Altaeva N, Kazhiyakhmetova B, Seitkumarova Z, Baidildina Y, Vizigina A, Kashkinbayev Y.   +6 more
europepmc   +1 more source

Review of articular cartilage repair techniques and their application in the horse

Equine Veterinary Journal, EarlyView.
Abstract Articular cartilage lesions represent a significant career‐limiting problem in athletic horses. A healthy articular cartilage surface is vital for optimal joint function, and defects can result in irreversible degenerative changes. Successful treatment of cartilage lesions remains a long‐standing challenge for orthopaedic surgeons, prompting ...
Charlotte K. Barton, Brad B. Nelson, Laurie R. Goodrich   +2 more
wiley   +1 more source

Mesenchymal Stromal Cells: Bridging the Gaps in Hematologic Disease Therapy. [PDF]

Stem Cell Rev Rep
Zhao X, Ming X, Wu J, Zhu X, Xiao Y.
europepmc   +1 more source