Results 221 to 230 of about 143,813 (266)
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Reinventing mesenchymal stromal cells
Cytotherapy, 2012The life-saving impact of chemotherapy and radiation has been as remarkable and momentous as any advance in the history of medicine. This becomes even more signifi cant when we remind ourselves that 50 years ago nearly all leukemias, lymphomas and aggressive solid tumors were fatal, and that nearly everything in oncology before the 20th century was a ...
Jakub, Tolar, Miroslav, Tolar
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Mesenchymal Stromal Cell Cryopreservation
Biopreservation and Biobanking, 2012The advent of stem cells and stem cell-based therapies for specific diseases requires particular knowledge of laboratory procedures, which not only guarantee the continuous production of cells, but also provide them an identity and integrity as close as possible to their origin.
Sabrina, Renzi +5 more
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Immunogenicity of mesenchymal stromal/stem cells
Scandinavian Journal of Immunology, 2023AbstractMesenchymal stromal/stem cells (MSCs) possess the ability to self‐renew and differentiate into other cell types. Because of their anti‐inflammatory and immunomodulatory abilities, as well as their more ready availability compared to other stem cell sources, MSCs hold great promise for the treatment of many diseases, such as haematological ...
Wenyan Chen, Lu Lv, Na Chen, Enhai Cui
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Mesenchymal stromal cells: an update
Current Opinion in HematologyPurpose of review Mesenchymal stromal cells (MSCs) are widely utilized in preclinical and clinical studies, with over 1500 clinical trials, including applications in Covid-19 treatment. This review consolidates recent advances in understanding MSC biology, mechanisms of action, and clinical utility.
Olivia J, Lee, Armand, Keating
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Challenges for mesenchymal stromal cell therapies
Science Translational Medicine, 2019Clinical trials of mesenchymal stromal cell therapies reveal a challenging heterogeneous landscape, including diverse therapeutic targets, patient categories, cell sources, and potential mechanisms of action.
Ivan Martin +4 more
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Multipotent mesenchymal stromal cells in otorhinolaryngology
Medical Hypotheses, 2014Multipotent mesenchymal stromal cells (MSCs) are primitive cells capable of restoring damaged mesenchyme and with the ability to differentiate into mature cells of bone, cartilage, muscle, fat, nerve or fibrous tissues. MSCs are therefore good candidates for applications in regenerative medicine and cell based therapy.
Lukas, Skoloudik +4 more
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Heterogeneity of mesenchymal stromal cell preparations
Cytotherapy, 2008As an archetype of human adult stem cells that can readily be harvested, enriched and expanded in vitro, mesenchymal stromal cells (MSC) have been reported to be of significance for regenerative medicine. The literature is replete with reports on their developmental potentials in pre-clinical model systems.
A D, Ho, W, Wagner, W, Franke
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Homing properties of mesenchymal stromal cells
Expert Opinion on Biological Therapy, 2014A large number of clinical trials are underway to assess the therapeutic potential of mesenchymal stromal cells. This is based on preclinical observations that point to the probable efficacy of these cells. Very little is known however about the homing mechanisms of these cells to sites of injury and inflammation. This is important if one is to enhance
Kallmeyer, Karlien, Pepper, Michael Sean
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Mesenchymal stromal cells for sphincter regeneration
Advanced Drug Delivery Reviews, 2015Stress urinary incontinence (SUI), defined as the involuntary loss of considerable amounts of urine during increased abdominal pressure (exertion, effort, sneezing, coughing, etc.), is a severe problem to the individuals affected and a significant medical, social and economic challenge.
Klein, Gerd +6 more
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The mesenchymal stromal cell contribution to homeostasis
Journal of Cellular Physiology, 2008AbstractAdult mesenchymal stromal cells (MSCs) are undifferentiated multi‐potent cells predominantly residing in the bone marrow (BM), but also present with similar but not identical features in many other tissues such as blood, placenta, dental pulp, and adipose tissue.
Mauro, Valtieri, Antonio, Sorrentino
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