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Cryopreservation and Revival of Mesenchymal Stromal Cells
2011Over the past few years, the pace of preclinical stem cell research is astonishing and adult stem cells have become the subject of intense research. Due to the presence of promising supporting preclinical data, human clinical trials for stem cell regenerative treatment of various diseases have been initiated.
Haack-Sørensen, Mandana, Kastrup, Jens
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Immunomodulation by Multipotent Mesenchymal Stromal Cells
Transplantation, 2007Multipotent mesenchymal stromal cells (MSC) are currently under intense investigation to determine their role in cellular therapy. They are a rare subset of cells, but are easy to isolate and possess an extensive proliferative potential. MSC differentiate into cell types of mesenchymal and nonmesenchymal lineages, providing a promising tool for tissue ...
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Annals of the New York Academy of Sciences, 2009
Mesenchymal stromal cells (MSCs) are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. MSCs are identified by their adherent properties, immunephenotype, and differentiation potential. MSCs display immunological properties that have been demonstrated both in vitro and in vivo, in animal models and ...
Maria Ester, Bernardo +2 more
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Mesenchymal stromal cells (MSCs) are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. MSCs are identified by their adherent properties, immunephenotype, and differentiation potential. MSCs display immunological properties that have been demonstrated both in vitro and in vivo, in animal models and ...
Maria Ester, Bernardo +2 more
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Mesenchymal stromal cells for treatment of arthritis
Best Practice & Research Clinical Rheumatology, 2014Patients with refractory inflammatory arthritis can still respond favourable to autologous haematopoietic stem cell transplantation. However, this treatment has a high morbidity and even 5% mortality. Mesenchymal stromal cells (MSC), a subset of the non-haematopoietic stromal cells obtained from bone marrow, were found to have a strong ...
J F, Swart, N M, Wulffraat
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Mesenchymal stromal cells and rheumatic disorders
Immunology Letters, 2015Mesenchymal stromal cells (MSC), often incorrectly called stem cells, have been the intense focus of in vitro studies and animal models of rheumatic and other diseases over more than a decade. Despite multiple plausible mechanisms of action and a plethora of positive in vivo animal studies, few randomised controlled clinical trials have demonstrated ...
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The Origins of Mesenchymal Stromal Cell Heterogeneity
Stem Cell Reviews and Reports, 2011Cultured mesenchymal stromal cell (MSC) populations are best characterized by the capacity of some cells within this population to differentiate into mesodermal derivatives such as osteoblasts, chondrocytes and adipocytes. However, this progenitor property is not shared by all cells within the MSC population.
Meirav, Pevsner-Fischer +2 more
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Mesenchymal Stem/Stromal Cells: MESENCHYMAL STEM/STROMAL CELLS
Cytotherapy, 2023E. Heyman +3 more
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Immunosuppressive Properties of Mesenchymal Stromal Cells
2012The main interest in mesenchymal stromal cells (MSCs) is correlated with their ability to suppress the proliferation of T lymphocytes induced by mitogenic agents and alloantigens which regulate the transplantation rejection. Moreover, MSCs are resistant to the CD8+ T lymphocyte cytotoxicity, they are able to inhibit the differentiation of dendritic ...
LANZA, Francesco +4 more
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The mesenchymal stem cell, the mesenchymal stromal cell, and the mesenchymal stromal cell exosome
2017Stem cells have two properties: they must be able to divide and be self-renewing and they must be able to differentiate down a specific lineage or set of lineages to produce functional cells. In the case of hematopoietic stem cells (HSC) this was readily shown first in animal models and subsequently in humans that if the recipient's bone marrow was ...
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Finessing the manufacture of mesenchymal stromal cells
Cytotherapy, 2014Mesenchymal stromal cells (MSCs) are an appealing cellular therapy, with early-phase clinical studies underway as therapies for acute graft-versus-host disease, inflammatory bowel disease, diabetes, wound repair and other diseases. The relative ease with which these cells can be expanded makes them especially appealing.
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