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Mesenchymal stromal cells therapy for remodeling the joint microenvironment: mechanisms, nanotechnology-enhanced strategies, and translation prospects. [PDF]

Stem Cell Res Ther
Shi Y, Ni Z, Wang F, Li Z, Li S, Li K, Chen X, Xu C, Wang F.   +8 more
europepmc   +1 more source

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Therapeutic applications of mesenchymal stromal cells

Seminars in Cell and Developmental Biology, 2007
Mesenchymal stromal cells (MSC) are multipotent cells that can be derived from many different organs and tissues. They have been demonstrated to play a role in tissue repair and regeneration in both preclinical and clinical studies. They also have remarkable immunosuppressive properties.
Alison Rice, Rebecca Pelekanos
exaly   +6 more sources

Reinventing mesenchymal stromal cells

Cytotherapy, 2012
The life-saving impact of chemotherapy and radiation has been as remarkable and momentous as any advance in the history of medicine. This becomes even more signifi cant when we remind ourselves that 50 years ago nearly all leukemias, lymphomas and aggressive solid tumors were fatal, and that nearly everything in oncology before the 20th century was a ...
Jakub, Tolar, Miroslav, Tolar
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Immunogenicity of mesenchymal stromal/stem cells

Scandinavian Journal of Immunology, 2023
AbstractMesenchymal stromal/stem cells (MSCs) possess the ability to self‐renew and differentiate into other cell types. Because of their anti‐inflammatory and immunomodulatory abilities, as well as their more ready availability compared to other stem cell sources, MSCs hold great promise for the treatment of many diseases, such as haematological ...
Wenyan Chen, Lu Lv, Na Chen, Enhai Cui
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Stromal Mesenchymal Progenitor Cells

Leukemia & Lymphoma, 1999
The precursors of bone, cartilage, fat and muscle cells are likely to be derived from more primitive mesenchymal cells which exhibit some of the characteristics of stem cells. Despite extensive study of stromal cell differentiation, neither mesenchymal stem cells or the more committed, tissue-specific progenitors have been well characterized.
R, Ghilzon, C A, McCulloch, R, Zohar
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Mesenchymal Stromal Cell Cryopreservation

Biopreservation and Biobanking, 2012
The advent of stem cells and stem cell-based therapies for specific diseases requires particular knowledge of laboratory procedures, which not only guarantee the continuous production of cells, but also provide them an identity and integrity as close as possible to their origin.
Sabrina, Renzi, Tina, Lombardo, Silvia, Dotti, Sara S, Dessì, Pasquale, De Blasio, Maura, Ferrari   +5 more
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Mesenchymal stromal cells: an update

Current Opinion in Hematology
Purpose of review Mesenchymal stromal cells (MSCs) are widely utilized in preclinical and clinical studies, with over 1500 clinical trials, including applications in Covid-19 treatment. This review consolidates recent advances in understanding MSC biology, mechanisms of action, and clinical utility.
Olivia J, Lee, Armand, Keating
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The mesenchymal stromal cell contribution to homeostasis

Journal of Cellular Physiology, 2008
AbstractAdult mesenchymal stromal cells (MSCs) are undifferentiated multi‐potent cells predominantly residing in the bone marrow (BM), but also present with similar but not identical features in many other tissues such as blood, placenta, dental pulp, and adipose tissue.
Mauro, Valtieri, Antonio, Sorrentino
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