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Heterogeneity of mesenchymal stromal cell preparations
Cytotherapy, 2008As an archetype of human adult stem cells that can readily be harvested, enriched and expanded in vitro, mesenchymal stromal cells (MSC) have been reported to be of significance for regenerative medicine. The literature is replete with reports on their developmental potentials in pre-clinical model systems.
A D, Ho, W, Wagner, W, Franke
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Homing properties of mesenchymal stromal cells
Expert Opinion on Biological Therapy, 2014A large number of clinical trials are underway to assess the therapeutic potential of mesenchymal stromal cells. This is based on preclinical observations that point to the probable efficacy of these cells. Very little is known however about the homing mechanisms of these cells to sites of injury and inflammation. This is important if one is to enhance
Kallmeyer, Karlien, Pepper, Michael Sean
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Mesenchymal stromal cells for sphincter regeneration
Advanced Drug Delivery Reviews, 2015Stress urinary incontinence (SUI), defined as the involuntary loss of considerable amounts of urine during increased abdominal pressure (exertion, effort, sneezing, coughing, etc.), is a severe problem to the individuals affected and a significant medical, social and economic challenge.
Klein, Gerd +6 more
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Mesenchymal stromal cells for treatment of arthritis
Best Practice & Research Clinical Rheumatology, 2014Patients with refractory inflammatory arthritis can still respond favourable to autologous haematopoietic stem cell transplantation. However, this treatment has a high morbidity and even 5% mortality. Mesenchymal stromal cells (MSC), a subset of the non-haematopoietic stromal cells obtained from bone marrow, were found to have a strong ...
J F, Swart, N M, Wulffraat
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Mesenchymal Stem/Stromal Cells: MESENCHYMAL STEM/STROMAL CELLS
Cytotherapy, 2023E. Heyman +3 more
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Annals of the New York Academy of Sciences, 2009
Mesenchymal stromal cells (MSCs) are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. MSCs are identified by their adherent properties, immunephenotype, and differentiation potential. MSCs display immunological properties that have been demonstrated both in vitro and in vivo, in animal models and ...
Maria Ester, Bernardo +2 more
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Mesenchymal stromal cells (MSCs) are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. MSCs are identified by their adherent properties, immunephenotype, and differentiation potential. MSCs display immunological properties that have been demonstrated both in vitro and in vivo, in animal models and ...
Maria Ester, Bernardo +2 more
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Challenges for mesenchymal stromal cell therapies
Science Translational Medicine, 2019Clinical trials of mesenchymal stromal cell therapies reveal a challenging heterogeneous landscape, including diverse therapeutic targets, patient categories, cell sources, and potential mechanisms of action.
Ivan Martin +4 more
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Immunomodulatory properties of mesenchymal stromal cells
Blood, 2007Abstract Mesenchymal stem cells (MSCs) are multipotential nonhematopoietic progenitor cells capable of differentiating into multiple lineages of the mesenchyme. MSCs have emerged as a promising therapeutic modality for tissue regeneration and repair.
Alma J, Nauta, Willem E, Fibbe
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Multipotent mesenchymal stromal cells in otorhinolaryngology
Medical Hypotheses, 2014Multipotent mesenchymal stromal cells (MSCs) are primitive cells capable of restoring damaged mesenchyme and with the ability to differentiate into mature cells of bone, cartilage, muscle, fat, nerve or fibrous tissues. MSCs are therefore good candidates for applications in regenerative medicine and cell based therapy.
Lukas, Skoloudik +4 more
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The mesenchymal stem cell, the mesenchymal stromal cell, and the mesenchymal stromal cell exosome
2017Stem cells have two properties: they must be able to divide and be self-renewing and they must be able to differentiate down a specific lineage or set of lineages to produce functional cells. In the case of hematopoietic stem cells (HSC) this was readily shown first in animal models and subsequently in humans that if the recipient's bone marrow was ...
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