Results 21 to 30 of about 138,445 (169)

Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors

Haematologica, 2009
Background Mesenchymal stromal cells are employed in various different clinical settings in order to modulate immune response. However, relatively little is known about the mechanisms responsible for their immunomodulatory effects, which could be ...
Maria Antonietta Avanzini, Maria Ester Bernardo, Angela Maria Cometa, Cesare Perotti, Nadia Zaffaroni, Francesca Novara, Livia Visai, Antonia Moretta, Claudia Del Fante, Raffaella Villa, Lynne M. Ball, Willem E. Fibbe, Rita Maccario, Franco Locatelli   +13 more
doaj   +1 more source

Gut Mesenchymal Stromal Cells in Immunity [PDF]

Stem Cells International, 2017
Mesenchymal stromal cells (MSCs), first found in bone marrow (BM), are the structural architects of all organs, participating in most biological functions. MSCs possess tissue-specific signatures that allow their discrimination according to their origin and location. Among their multiple functions, MSCs closely interact with immune cells, orchestrating
Messina V., Buccione C., Marotta G., Ziccheddu G., Signore M., Mattia G., Puglisi R., Sacchetti B., Biancone L., Valtieri M.   +9 more
openaire   +3 more sources

Mesenchymal stromal cells transiently alter the inflammatory milieu post-transplant to delay graft-versus-host disease

Haematologica, 2010
Background Multipotent mesenchymal stromal cells suppress T-cell function in vitro, a property that has underpinned their use in treating clinical steroid-refractory graft-versus-host disease after allogeneic hematopoietic stem cell transplantation ...
Melinda E. Christensen, Brie E. Turner, Laura J. Sinfield, Katarina Kollar, Hannah Cullup, Nigel J. Waterhouse, Derek N.J. Hart, Kerry Atkinson, Alison M. Rice   +8 more
doaj   +1 more source

Down-regulation of Dicer1 promotes cellular senescence and decreases the differentiation and stem cell-supporting capacities of mesenchymal stromal cells in patients with myelodysplastic syndrome

Haematologica, 2015
Although it has been reported that mesenchymal stromal cells are unable to provide sufficient hematopoietic support in myelodysplastic syndrome, the underlying mechanisms remain elusive.
Youshan Zhao, Dong Wu, Chengming Fei, Juan Guo, Shuncheng Gu, Yang Zhu, Feng Xu, Zheng Zhang, Lingyun Wu, Xiao Li, Chunkang Chang   +10 more
doaj   +1 more source

How to Make Sense out of 75,000 Mesenchymal Stromal Cell Publications?

Cells, 2022
Mesenchymal stromal cells have been the subject of an expanding number of studies over the past decades. Today, over 75,000 publications are available that shine light on the biological properties and therapeutic effects of these versatile cells in ...
Dina Mönch, Marlies E. J. Reinders, Marc H. Dahlke, Martin J. Hoogduijn   +3 more
doaj   +1 more source

Mesenchymal stromal cells as universal donor cells [PDF]

Expert Opinion on Biological Therapy, 2012
Stem cell transplantation is a promising approach for improving cardiac function after severe myocardial damage for which use of autologous cells have been preferred to avoid immune rejection. Recently, however, rodent as well as human mesenchymal stromal cells (MSCs) have been reported to be uniquely immune tolerant, both in in vitro as well as in ...
Rony, Atoui, Ray C J, Chiu
openaire   +2 more sources

Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions

Haematologica, 2010
Background Research on mesenchymal stromal cells has created high expectations for a variety of therapeutic applications. Extensive propagation to yield enough mesenchymal stromal cells for therapy may result in replicative senescence and thus hamper ...
Katharina Schallmoser, Christina Bartmann, Eva Rohde, Simone Bork, Christian Guelly, Anna C. Obenauf, Andreas Reinisch, Patrick Horn, Anthony D. Ho, Dirk Strunk, Wolfgang Wagner   +10 more
doaj   +1 more source

Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modeling the niche compartments in vitro

Haematologica, 2010
Background Hematopoietic stem cells located in the bone marrow interact with a specific microenvironment referred to as the stem cell niche. Data derived from ex vivo co-culture systems using mesenchymal stromal cells as a feeder cell layer suggest that ...
Duohui Jing, Ana-Violeta Fonseca, Nael Alakel, Fernando A. Fierro, Katrin Muller, Martin Bornhauser, Gerhard Ehninger, Denis Corbeil, Rainer Ordemann   +8 more
doaj   +1 more source

ENCAPSULATION OF MESENCHYMAL STROMAL CELLS IN ALGINATE MICROSPHERES [PDF]

Biotechnologia Acta, 2016
The research aim work was a comparative study of structural and functional state and capacity for differentiation of multipotent mesenchymal stromal cells, stored at various temperatures either as cell suspensions or within alginate microspheres. Storage
Mazur, Volkova, Petrenko, Zaikov,, Petrenko, Tarusin   +5 more
doaj   +1 more source

Human olfactory mesenchymal stromal cells co-expressing horizontal basal and ensheathing cell proteins in culture

Biomédica: revista del Instituto Nacional de Salud, 2020
Introduction: The olfactory neuro-epithelium has an intrinsic capability of renewal during lifetime provided by the existence of globose and horizontal olfactory precursor cells.
Carlos Ayala-Grosso, Rosalinda Pieruzzini, Leslie Vargas-Saturno, José E. Cardier   +3 more
doaj   +1 more source