Results 31 to 40 of about 143,813 (266)

Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis

Haematologica, 2010
Background Residual chronic myeloid leukemia disease following imatinib treatment has been attributed to the presence of quiescent leukemic stem cells intrinsically resistant to imatinib.
Fabrizio Vianello, Federica Villanova, Veronica Tisato, Stefania Lymperi, Ka-Kei Ho, Ana R. Gomes, David Marin, Dominique Bonnet, Jane Apperley, Eric W.-F. Lam, Francesco Dazzi   +10 more
doaj   +1 more source

Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vδ 2 T lymphocytes in non-Hodgkin lymphomas

Haematologica, 2014
In this study, we analyzed the influence of mesenchymal stromal cells derived from lymph nodes of non-Hodgkin’s lymphomas, on effector functions and differentiation of Vdelta (δ)2 T lymphocytes.
Alessandra Musso, Silvia Catellani, Paolo Canevali, Sara Tavella, Roberta Venè, Silvia Boero, Ivana Pierri, Marco Gobbi, Annalisa Kunkl, Jean-Louis Ravetti, Maria Raffaella Zocchi, Alessandro Poggi   +11 more
doaj   +1 more source

Isolation of human bone marrow stromal cells from bone marrow biopsies for single-cell RNA sequencing

STAR Protocols, 2021
Summary: Bone marrow (BM) mesenchymal stromal cells play an important role in regulating stem cell quiescence and homeostasis; they are also key contributors to various hematological malignancies. However, human bone marrow stromal cells are difficult to
Hélène F.E. Gleitz, Inge A.M. Snoeren, Stijn N.R. Fuchs, Nils B. Leimkühler, Rebekka K. Schneider   +4 more
doaj   +1 more source

Mesenchymal Stromal Cells

Biology of Blood and Marrow Transplantation, 2007
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Horwitz, Edwin M., Andreef, Michael, Frassoni, Francesco   +2 more
openaire   +1 more source

The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties. [PDF]

PLoS ONE, 2013
Mesenchymal stromal cells are non-hematopoietic, multipotent progenitor cells producing cytokines, chemokines, and extracellular matrix proteins that support hematopoietic stem cell survival and engraftment, influence immune effector cell development ...
Francesca Rossi, Maria Ester Bernardo, Giulia Bellini, Livio Luongo, Antonella Conforti, Iolanda Manzo, Francesca Guida, Luigia Cristino, Roberta Imperatore, Stefania Petrosino, Bruno Nobili, Vincenzo Di Marzo, Franco Locatelli, Sabatino Maione   +13 more
doaj   +1 more source

Mesenchymal stromal cells in myeloid malignancies [PDF]

Blood Research, 2016
Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal myeloid disorders characterized by hematopoietic insufficiency. As MDS and AML are considered to originate from genetic and molecular defects of hematopoietic stem and progenitor cells (HSPC), the main focus of research in this field has focused on the characterization of these
Schroeder, Thomas, Geyh, Stefanie, Germing, Ulrich, Haas, Rainer   +3 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Oxygen tension plays a critical role in the hematopoietic microenvironment in vitro

Haematologica, 2012
Background In the bone marrow mesenchymal stromal cells and osteoblasts form functional niches for hematopoietic stem and progenitor cells. This microenvironment can be partially mimicked using in vitro co-culture systems.
Duohui Jing, Manja Wobus, David M. Poitz, Martin Bornhäuser, Gerhard Ehninger, Rainer Ordemann   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Mesenchymal stromal cells from pooled mononuclear cells of multiple bone marrow donors as rescue therapy in pediatric severe steroid-refractory graft-versus-host disease: a multicenter survey

Haematologica, 2016
To circumvent donor-to-donor heterogeneity which may lead to inconsistent results after treatment of acute graft-versus-host disease with mesenchymal stromal cells generated from single donors we developed a novel approach by generating these cells from ...
Zyrafete Kuçi, Halvard Bönig, Hermann Kreyenberg, Milica Bunos, Anna Jauch, Johannes W.G. Janssen, Marijana Škifić, Kristina Michel, Ben Eising, Giovanna Lucchini, Shahrzad Bakhtiar, Johann Greil, Peter Lang, Oliver Basu, Irene von Luettichau, Ansgar Schulz, Karl-Walter Sykora, Andrea Jarisch, Jan Soerensen, Emilia Salzmann-Manrique, Erhard Seifried, Thomas Klingebiel, Peter Bader, Selim Kuçi   +23 more
doaj   +1 more source