Results 41 to 50 of about 4,624,864 (302)

Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vδ 2 T lymphocytes in non-Hodgkin lymphomas

Haematologica, 2014
In this study, we analyzed the influence of mesenchymal stromal cells derived from lymph nodes of non-Hodgkin’s lymphomas, on effector functions and differentiation of Vdelta (δ)2 T lymphocytes.
Alessandra Musso, Silvia Catellani, Paolo Canevali, Sara Tavella, Roberta Venè, Silvia Boero, Ivana Pierri, Marco Gobbi, Annalisa Kunkl, Jean-Louis Ravetti, Maria Raffaella Zocchi, Alessandro Poggi   +11 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties. [PDF]

PLoS ONE, 2013
Mesenchymal stromal cells are non-hematopoietic, multipotent progenitor cells producing cytokines, chemokines, and extracellular matrix proteins that support hematopoietic stem cell survival and engraftment, influence immune effector cell development ...
Francesca Rossi, Maria Ester Bernardo, Giulia Bellini, Livio Luongo, Antonella Conforti, Iolanda Manzo, Francesca Guida, Luigia Cristino, Roberta Imperatore, Stefania Petrosino, Bruno Nobili, Vincenzo Di Marzo, Franco Locatelli, Sabatino Maione   +13 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Characterization of mesenchymal stromal cell-mediated mitochondrial transfer to healthy and diseased intervertebral disc cells.

PLoS ONE
Intradiscal injection of mesenchymal stromal cells has gained widespread interest for the treatment of intervertebral disc degeneration. Mesenchymal stromal cells have been shown to impart a therapeutic benefit on treated tissues through a variety of ...
Ashley Cardenas, Noah Willett, Anthony Robayo, Jessica Berger, Blake Boadi, Chibuikem A Ikwuegbuenyi, Ibrahim Hussain, Roger Härtl, Lawrence J Bonassar   +8 more
doaj   +1 more source

Oxygen tension plays a critical role in the hematopoietic microenvironment in vitro

Haematologica, 2012
Background In the bone marrow mesenchymal stromal cells and osteoblasts form functional niches for hematopoietic stem and progenitor cells. This microenvironment can be partially mimicked using in vitro co-culture systems.
Duohui Jing, Manja Wobus, David M. Poitz, Martin Bornhäuser, Gerhard Ehninger, Rainer Ordemann   +5 more
doaj   +1 more source

Isolation of human bone marrow stromal cells from bone marrow biopsies for single-cell RNA sequencing

STAR Protocols, 2021
Summary: Bone marrow (BM) mesenchymal stromal cells play an important role in regulating stem cell quiescence and homeostasis; they are also key contributors to various hematological malignancies. However, human bone marrow stromal cells are difficult to
Hélène F.E. Gleitz, Inge A.M. Snoeren, Stijn N.R. Fuchs, Nils B. Leimkühler, Rebekka K. Schneider   +4 more
doaj   +1 more source

Mesenchymal Stromal Cells as a Driver of Inflammaging

International Journal of Molecular Sciences, 2023
Life expectancy and age-related diseases burden increased significantly over the past few decades. Age-related conditions are commonly discussed in a very limited paradigm of depleted cellular proliferation and maturation with exponential accumulation of senescent cells. However, most recent evidence showed that the majority of age-associated ailments,
Svetlana Lyamina, Denis Baranovskii, Ekaterina Kozhevnikova, Tatiana Ivanova, Sergey Kalish, Timur Sadekov, Ilya Klabukov, Igor Maev, Vadim Govorun   +8 more
openaire   +3 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Mesenchymal stromal cells from pooled mononuclear cells of multiple bone marrow donors as rescue therapy in pediatric severe steroid-refractory graft-versus-host disease: a multicenter survey

Haematologica, 2016
To circumvent donor-to-donor heterogeneity which may lead to inconsistent results after treatment of acute graft-versus-host disease with mesenchymal stromal cells generated from single donors we developed a novel approach by generating these cells from ...
Zyrafete Kuçi, Halvard Bönig, Hermann Kreyenberg, Milica Bunos, Anna Jauch, Johannes W.G. Janssen, Marijana Škifić, Kristina Michel, Ben Eising, Giovanna Lucchini, Shahrzad Bakhtiar, Johann Greil, Peter Lang, Oliver Basu, Irene von Luettichau, Ansgar Schulz, Karl-Walter Sykora, Andrea Jarisch, Jan Soerensen, Emilia Salzmann-Manrique, Erhard Seifried, Thomas Klingebiel, Peter Bader, Selim Kuçi   +23 more
doaj   +1 more source