Results 51 to 60 of about 143,813 (266)

Interplay between mesenchymal stromal cells and the immune system after transplantation: implications for advanced cell therapy in the retina

Neural Regeneration Research
Advanced mesenchymal stromal cell-based therapies for neurodegenerative diseases are widely investigated in preclinical models. Mesenchymal stromal cells are well positioned as therapeutics because they address the underlying mechanisms of ...
María Norte-Muñoz, David García-Bernal, Diego García-Ayuso, Manuel Vidal-Sanz, Marta Agudo-Barriuso   +4 more
doaj   +1 more source

Co-transplantation of Human Fetal Mesenchymal and Hematopoietic Stem Cells in Type 1 Diabetic Mice Model

Frontiers in Endocrinology, 2019
Introduction: Cell therapy can overcome the limitation of conventional treatments (including different medications and β cell replacement) for type 1 diabetes.
Babak Arjmand, Babak Arjmand, Parisa Goodarzi, Hamid Reza Aghayan, Moloud Payab, Fakher Rahim, Sepideh Alavi-Moghadam, Fereshteh Mohamadi-jahani, Bagher Larijani   +8 more
doaj   +1 more source

Mesenchymal Stromal Cells as a Driver of Inflammaging

International Journal of Molecular Sciences, 2023
Life expectancy and age-related diseases burden increased significantly over the past few decades. Age-related conditions are commonly discussed in a very limited paradigm of depleted cellular proliferation and maturation with exponential accumulation of senescent cells. However, most recent evidence showed that the majority of age-associated ailments,
Svetlana Lyamina, Denis Baranovskii, Ekaterina Kozhevnikova, Tatiana Ivanova, Sergey Kalish, Timur Sadekov, Ilya Klabukov, Igor Maev, Vadim Govorun   +8 more
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Mesenchymal stem cells: the fibroblasts’ new clothes?

Haematologica, 2009
Mesenchymal stem cells are adherent stromal cells, initially isolated from the bone marrow, characterized by their ability to differentiate into mesenchymal tissues such as bone, cartilage and fat.
Muzlifah A. Haniffa, Matthew P. Collin, Christopher D. Buckley, Francesco Dazzi   +3 more
doaj   +1 more source

The Potential of Mesenchymal Stromal Cells in Immunotherapy [PDF]

Immunotherapy, 2016
info:eu-repo/semantics ...
Fayyad Kazan, Mohammad, Fayyad Kazan, Hussein, Lagneaux, Laurence, Najar, Mehdi   +3 more
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients

Haematologica, 2012
Background Recent findings suggest that a specific deletion of Dicer1 in mesenchymal stromal cell-derived osteoprogenitors triggers several features of myelodysplastic syndrome in a murine model.
Carlos Santamaría, Sandra Muntión, Beatriz Rosón, Belén Blanco, Olga López-Villar, Soraya Carrancio, Fermín M. Sánchez-Guijo, María Díez-Campelo, Stela Alvarez-Fernández, María E. Sarasquete, Javier de las Rivas, Marcos González, Jesús F. San Miguel, María Consuelo del Cañizo   +13 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source