Results 51 to 60 of about 138,445 (169)

Canonical signaling by TGF family members in mesenchymal stromal cells is dispensable for hematopoietic niche maintenance under basal and stress conditions.

PLoS ONE, 2020
Mesenchymal stromal cells are an important component of the bone marrow hematopoietic niche. Prior studies showed that signaling from members of the transforming growth factor (TGF) superfamily in mesenchymal stromal cells is required for normal niche ...
Joseph Ryan Krambs, Grazia Abou Ezzi, Juo-Chin Yao, Daniel C Link   +3 more
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Mesenchymal stromal cells for cardiovascular disease [PDF]

Journal of Cardiovascular Disease Research, 2011
The fields of regenerative medicine and cellular therapy have been the subject of tremendous hype and hope. In particular, the perceived usage of somatic cells like mesenchymal stromal cells (MSCs) has captured the imagination of many. MSCs are a rare population of cells found in multiple regions within the body that can be readily expanded ex vivo and
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Transforming growth factor β1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia

Haematologica, 2018
Mesenchymal stromal cells are involved in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia, but the underlying mechanisms are incompletely understood.
Stefanie Geyh, Manuel Rodríguez-Paredes, Paul Jäger, Annemarie Koch, Felix Bormann, Julian Gutekunst, Christoph Zilkens, Ulrich Germing, Guido Kobbe, Frank Lyko, Rainer Haas, Thomas Schroeder   +11 more
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Gene-expression and in vitro function of mesenchymal stromal cells are affected in juvenile myelomonocytic leukemia

Haematologica, 2015
An aberrant interaction between hematopoietic stem cells and mesenchymal stromal cells has been linked to disease and shown to contribute to the pathophysiology of hematologic malignancies in murine models.
Friso G.J. Calkoen, Carly Vervat, Else Eising, Lisanne S. Vijfhuizen, Peter-Bram A.C. ‘t Hoen, Marry M. van den Heuvel-Eibrink, R. Maarten Egeler, Maarten J.D. van Tol, Lynne M. Ball   +8 more
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Multipotent human stromal cells isolated from cord blood, term placenta and adult bone marrow show distinct differences in gene expression pattern

Genomics Data, 2015
Multipotent mesenchymal stromal cells derived from human placenta (pMSCs), and unrestricted somatic stem cells (USSCs) derived from cord blood share many properties with human bone marrow-derived mesenchymal stromal cells (bmMSCs) and are currently in ...
Nicholas Matigian, Gary Brooke, Faten Zaibak, Tony Rossetti, Katarina Kollar, Rebecca Pelekanos, Celena Heazlewood, Alan Mackay-Sim, Christine A. Wells, Kerry Atkinson   +9 more
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Morphological, Ultrastructural, and Molecular Aspects of In Vitro Mouse Embryo Implantation on Human Endometrial Mesenchymal Stromal Cells in The Presence of Steroid Hormones as An Implantation Model

Cell Journal, 2018
Objective This experimental study aimed to evaluate the effects of 17β-estradiol (E2) and progesterone (P4) on the interaction between mouse embryo and human endometrial mesenchymal stromal cells, and gene expressions related to implantation [αV and β3 ...
Marzieh Rahimipour, Mojdeh Salehnia, Mina Jafarabadi   +2 more
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Methods and efficacy of extracellular vesicles derived from mesenchymal stromal cells in animal models of disease: a preclinical systematic review protocol

Systematic Reviews, 2019
Background Over the past decade, mesenchymal stromal cells have been increasingly investigated for their therapeutic potential in several different illnesses.
Alvin Tieu, Mitchell Slobodian, Dean A. Fergusson, Joshua Montroy, Dylan Burger, Duncan J. Stewart, Risa Shorr, David S. Allan, Manoj M. Lalu   +8 more
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Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells

Haematologica, 2014
Multiple myeloma is an incurable hematologic cancer characterized by the clonal proliferation of malignant plasma cells within the bone marrow. Numerous studies suggest that the myeloma plasma cells occupy and alter the stromal tissue of the bone marrow ...
Jacqueline E. Noll, Sharon A. Williams, Christine M. Tong, Hongsheng Wang, Julie M. Quach, Louise E. Purton, Katherine Pilkington, Luen B. To, Andreas Evdokiou, Stan Gronthos, Andrew C.W. Zannettino   +10 more
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The Immunosuppressive Effect of Mesenchymal Stromal Cells on B Lymphocytes is Mediated by Membrane Vesicles

Cell Transplantation, 2013
The immunomodulatory properties of mesenchymal stromal cells are the subject of increasing interest and of widening clinical applications, but the reproducibility of their effects is controversial and the underlying mechanisms have not been fully ...
Manuela Budoni, Alessandra Fierabracci, Rosa Luciano, Stefania Petrini, Vincenzo Di Ciommo, Maurizio Muraca   +5 more
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Mechanisms of mesenchymal stromal cell immunomodulation [PDF]

Immunology & Cell Biology, 2012
Multipotent mesenchymal stromal cells (MSCs) have generated considerable interest in the fields of regenerative medicine, cell therapy and immune modulation. Over the past 5 years, the initial observations that MSCs could enhance regeneration and modulate immune responses have been significantly advanced and we now have a clearer picture of the effects
openaire   +3 more sources