BMP4 initiates and patterns ventral-caudal structures in zebrafish and human pluripotent stem cell aggregates. [PDF]
Xing YY +14 more
europepmc +1 more source
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito +9 more
wiley +1 more source
Segregation of endoderm and mesoderm germ layer identities in the diploblast Nematostella vectensis. [PDF]
Haillot E +6 more
europepmc +1 more source
Ectopic Expression of T‐Box Transcription Factors Alters Mouse Forelimb Formation
ABSTRACT The developing vertebrate forelimb expresses seven T‐box transcription factors, with several in overlapping expression domains. All T‐box transcription family members share similarity within their DNA binding domain, the T‐domain. Outside of the T‐domain, these factors share little similarity, allowing family members to have different ...
Mariah H. Denhart, Deborah L. Chapman
wiley +1 more source
Paxillin is crucial for thymus and parathyroid development by regulating the architecture of the third pharyngeal pouch endoderm. [PDF]
Iacolare O +6 more
europepmc +1 more source
Metamorphosis and lncRNAs: A Close Relationship
ABSTRACT The classical definition of metamorphosis is a post‐embryonic transformation, such as from a tadpole to a froglet. However, recent studies suggest this process occurs to some degree in all vertebrates, as the underlying endocrine and molecular pathways are highly conserved. With the advent of high‐throughput sequencing, transcriptomic data for
H. Herrera‐Orozco +1 more
wiley +1 more source
Construction and Expression Analysis of the <i>bin <sup>3xOllas</sup></i> Tool Line. [PDF]
Yi M +3 more
europepmc +1 more source
Micro Pattern‐Based 3D Cell Culture Platform: An Overview of Technologies and Applications
Micro patterns are characterized as a coating of specific adhesion matrices on substrates to support cell growth. An overview of micropattern technology to regulate single cell morphology and fates, further focusing on the micro pattern‐based 3D cell culture platform used in the non‐tumor and tumor researches.
Xinglong Zhu +8 more
wiley +1 more source
Protocol for differentiation of vascular smooth muscle cells from human iPSCs and their application in CRISPRa-mediated gene regulation. [PDF]
Priesmeier L, Tiburcy M, Zelarayán LC.
europepmc +1 more source
Genomic studies implicate RBFOX1 in Alzheimer's disease (AD) risk, highlighting the need to define its role and interactions with other risk factors. Here, CRISPR/Cas9‐mediated RBFOX1 loss in APOE4 human cerebral organoids induces autonomous microglial genesis and accelerates AD pathology, revealing a protective role of RBFOX1 and establishing a model ...
Bowen Zhang +13 more
wiley +1 more source

