Results 191 to 200 of about 95,300 (301)

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, Volume 13, Issue 24, 27 April 2026.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

Traffic and functional polarization of macrophages in the areas of programmed interdigital cell death in the embryonic chick. [PDF]

Apoptosis
Moran G, Duarte-Olivenza C, Hurle JM, Lorda-Diez CI, Montero JA.   +4 more
europepmc   +1 more source

Vascularized Cardiac Tissue Engineering: From Advances in Biofabrication to Translational Applications

Advanced Science, Volume 13, Issue 23, 23 April 2026.
This review presents a process‐oriented framework for vascularized cardiac tissue engineering, highlighting how the coordinated design of cells, biomaterials, and biofabrication strategies enables the functional development or vascularized myocardium for disease modelling and drug discovery.
Yang Liu, Zijie Zhang, Hongbin Li, Lino Prados‐Martin, Huanhong Li, Feng Cheng, Xia Tu, Khoon S. Lim, Wanlu Li, Mian Wang   +9 more
wiley   +1 more source

Targeted CRISPR-Cas9 screening identifies core transcription factors controlling murine haemato-endothelial fate commitment. [PDF]

Nat Commun
Teske M, Wertheimer T, Butz S, Zwicky P, Mallona I, Nopper SL, Münz C, Elling U, Lancrin C, Becher B, Grosso AR, Baubec T, Schmolka N.   +12 more
europepmc   +1 more source

Tracking tau and cellular responses in human iPSC‐microglia: from uptake to seedable secretion, including in extracellular vesicles

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Microglia have been implicated in the templated spread of tau aggregates in tauopathies through mouse studies. However, it is unclear whether these findings translate to human disease. METHODS We challenged human induced pluripotent stem cell (iPSC)‐derived microglia‐like‐cells (iMGL) with monomeric and fibrillar recombinant tau ...
Maria Kreger Karabova, Anna del Ser‐Badia, Anne Hedegaard, Sam J. Washer, Zeynep Baykam, Darragh P. O'Brien, Iolanda Vendrell, Svenja S. Hester, Roman Fischer, Errin Johnson, Charlotte E. Melia, Teige R. S. Matthews‐Palmer, Rishi Matadeen, Alessia Santambrogio, Michael A. Metrick II, Michele Vendruscolo, Sophie Keeling, Kimberly Ai Xian Cheam, William A. McEwan, Kenneth S. Kosik, Theresa A. Day, William S. James, Sally A. Cowley   +22 more
wiley   +1 more source

A Hypoxia-reoxygenation Injury Model in Self-assembling Human Cardioids. [PDF]

J Vis Exp
Parker LE, Thomas MC, Williams AB, Weirnick R, Ogliari AS, Karpurapu A, Barreto C, Manepalli S, Peña KC, Brandt AN, Booth M, Dalal NA, Lou F, Beard AJ, Karra R.   +14 more
europepmc   +1 more source

Human iPSC‐derived GABAergic interneuron transplantation restores circuit balance and cognitive function in an Alzheimer's disease model

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is characterized by disrupted excitatory–inhibitory (E:I) balance and impaired synaptic function, yet current treatments fail to repair these fundamental circuit impairments. METHODS Human induced pluripotent stem cell‐derived post‐mitotic medial ganglionic eminence‐originated inhibitory neurons (MGE‐pINs)
Xinzhe Zhang, Gaojie Wang, Haodong Chen, Ye Sun, Ziteng Wangliu, Lijing Wang, Miao Sun, Qing Liu, Xue Zhang   +8 more
wiley   +1 more source

Blastocoeldach-Polarität und richtungsweisende Signale bei der Mesodermwanderung in der Xenopus-Gastrula [PDF]

, 2001
Nagel, Martina
core  

Constructing the spatiotemporal atlas of single-cell lineage trajectories in stereotypic biological structures. [PDF]

iScience
Wang R, Yang X, Lian C, Wang J, Chen J, Qian Y, Xu Y, Wang L, Marioni JC, Tam PPL, Jing N.   +10 more
europepmc   +1 more source

Mechanisms Underlying the Initiation and Termination of Collective Cell Migration: Perspectives for Understanding Development and Cancer Metastasis

BioEssays, Volume 48, Issue 4, April 2026.
How collective cell migration starts and stops is a fundamental question but remains poorly understood. This review discusses the distinct mechanisms in in vivo models and cancer metastasis that define the regulatory pathways and collective features governing the initiation and termination of collective cell migration.
Guangxia Miao
wiley   +1 more source