Results 21 to 30 of about 14,564 (138)

Rugged Metropolis Sampling with Simultaneous Updating of Two Dynamical Variables [PDF]

, 2005
The Rugged Metropolis (RM) algorithm is a biased updating scheme, which aims at directly hitting the most likely configurations in a rugged free energy landscape. Details of the one-variable (RM$_1$) implementation of this algorithm are presented.
B. A. Berg, Bernd A. Berg, D. Frenkel, G. E. Schultz, Huan-Xiang Zhou, N. A. Alves, Y. Peng, Z. Li   +7 more
core   +1 more source

Influence of Mutations of Conserved Arginines on Neuropeptide Binding in the DPP III Active Site

Molecules, 2023
Dipeptidyl peptidase III (DPP III), a zinc exopeptidase, is involved in the final steps of intercellular protein degradation and has a marked affinity for opioid peptides such as enkephalins and endomorphins.
Antonija Tomić, Zrinka Karačić, Sanja Tomić   +2 more
doaj   +1 more source

Comparative Study of Multicanonical and Simulated Annealing Algorithms in the Protein Folding Problem [PDF]

, 1994
We compare a few variants of the recently proposed multicanonical method with the well known simulated annealing for the effectiveness in search of the energy global minimum of a biomolecular system. For this we study in detail Met-enkephalin, one of the
Affinger, Berg, Berg, Berg, Berg, Berg, Berg, Brünger, Brünger, Celik, Chou, Ferrenberg, Ferrenberg, Fukugita, Garrett, Goodsell, Hansmann, Hansmann, Kawai, Kawai, Kirkpatrick, Levitt, Li, Metropolis, Momany, Nakai, Nakazawa, Nilges, Némethy, Okamoto, Okamoto, Okamoto, Okamoto, Okamoto, Shakhnovich, Sipple, Ulrich H.E. Hansmann, von Freyberg, Wilson, Wilson, Wilson, Yuko Okamoto   +41 more
core   +3 more sources

Cytogenetic effects of combination of tridecactide and met-enkephalin on lymphocytes of patients with multiple sclerosis

Journal of Health Sciences, 2015
Introduction: The met-enkephalin (1-5 Adrenorphin) and tridecactide (alpha-corticotropin 1-13) combination is used in the multiple sclerosis (MS) immuno-modulatory treatment.
Maida Rakanovic-Todic, Slavka Ibrulj, Lejla Burnazovic-Ristic, Amra Catovic, Izeta Aganovic-Musinovic, Jasna Kusturica   +5 more
doaj   +1 more source

Stochastic dynamics simulations in a new generalized ensemble [PDF]

, 1998
We develop a formulation for molecular dynamics, Langevin, and hybrid Monte Carlo algorithms in the recently proposed generalized ensemble that is based on a physically motivated realisation of Tsallis weights. The effectiveness of the methods are tested
Andricioaei, Berg, Duane, Eisenmenger, Frank Eisenmenger, Hansmann, Hansmann, Hansmann, Hansmann, Hesselbo, Lyubartsev, Marinari, Mazur, Meirovitch, Metropolis, Momany, Nakajima, Némethy, Parisi, Sippl, Stariolo, Tsallis, Ulrich H.E. Hansmann, Verlet, Yuko Okamoto   +24 more
core   +3 more sources

Human hepatic met-enkephalin and delta opioid receptor-1 immunoreactivities in viral and autoimmune hepatitis

Annals of Hepatology, 2008
Endogenous opioids participate in growth regulation. Liver regeneration relates to growth. Thus, we explored the expression of methionine enkephalin and of the delta opioid receptor 1 immunoreactivities with a polyclonal rabbit antibody in deparaffinized
Vijaya D. Boyella, Anthony D. Nicastri, Nora V. Bergasa   +2 more
doaj   +1 more source

Effective Sampling in the Configurational Space by the Multicanonical-Multioverlap Algorithm

, 2006
We propose a new generalized-ensemble algorithm, which we refer to as the multicanonical-multioverlap algorithm. By utilizing a non-Boltzmann weight factor, this method realizes a random walk in the multi-dimensional, energy-overlap space and explores ...
B. A. Berg, M. H. Quenouille, R. G. Miller, Satoru G. Itoh, Y. Sugita, Yuko Okamoto   +5 more
core   +1 more source

Effects of loperamide on the human hypothalamo-pituitary-adrenal axis in vivo and in vitro. [PDF]

, 1992
Loperamide, an opiate agonist of high specificity for p-receptors, was recently reported to suppress ACTH and cortisol levels in normal subjects, but not in patients with proven ACTH-dependent Cushing’s disease. However, there is little information on
Auernhammer, Christoph J., Lange, M., Müller, O.A., Pfeiffer, M., Stalla, G.K.   +4 more
core   +1 more source

Perspectives on Endogenous Opioids in Birds

Frontiers in Physiology, 2018
The present review summarizes the state of knowledge of endogenous opioids in birds. Endogenous opioid peptides acts in a neuromodulatory, hormonal and paracrine manner to mediate analgesic and other physiological functions.
Colin G. Scanes, Krystyna Pierzchala-Koziec   +1 more
doaj   +1 more source

Reconstructing the free-energy landscape of Met-enkephalin using dihedral Principal Component Analysis and Well-tempered Metadynamics

, 2012
Well-Tempered Metadynamics (WTmetaD) is an efficient method to enhance the reconstruction of the free-energy surface of proteins. WTmetaD guarantees a faster convergence in the long time limit in comparison with the standard metadynamics.
François Sicard, Patrick Senet, Rapaka R. S.   +2 more
core   +3 more sources