Results 41 to 50 of about 1,366,906 (203)

Targeted Cell Reprogramming Produces Analgesic Chromaffin-Like Cells from Human Mesenchymal Stem Cells

open access: yesCell Transplantation, 2013
Transplantation of allogeneic adrenal chromaffin cells demonstrated the promise of favorable outcomes for pain relief in patients. However, there is a very limited availability of suitable human adrenal gland tissues, genetically well-matched donors in ...
T. Qu M.D., Ph.D.   +5 more
doaj   +1 more source

Endotoxins and Biological Implications—Review

open access: yesPublic Health Challenges, Volume 5, Issue 4, December 2026.
Graphical overview of endotoxin sources, exposure routes, biological effects, detection methods, and routes of elimination. ABSTRACT Endotoxins, also known as lipopolysaccharides (LPSs), are structural components of the outer membrane of Gram‐negative bacteria and some cyanobacteria.
Uzair Ishtiaq   +5 more
wiley   +1 more source

Plasma native and peptidase-derivable Met-enkephalin responses to restraint stress in rats. Adaptation to repeated restraint. [PDF]

open access: yes, 1990
Met-enkephalin and related proenkephalin A-derived peptides circulate in plasma at picomolar concentration as free, native pentapeptide and at nanomolar concentration in cryptic forms.
K Pierzchala   +3 more
core   +1 more source

The Role of Ultra‐Low‐Dose Naloxone as an Additive in Anesthesia and Nerve Block: A Systematic Review

open access: yesHealth Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims In anesthesia and analgesia, opioids alone or in combination with local anesthetics (bupivacaine, lidocaine, and ropivacaine) have been investigated to prolong peripheral nerve blocks. Ultra‐low‐dose naloxone administration in local anesthetic solutions could lengthen sensory and motor blocks through enhanced opioid effects
Mohammadjavad Mehrabanian   +7 more
wiley   +1 more source

Genetically Engineered Human Mesenchymal Stem Cells Produce Met-Enkephalin at Augmented Higher Levels in Vitro

open access: yesCell Transplantation, 2006
We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain.
Ikuko Sugaya   +3 more
doaj   +1 more source

The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma. [PDF]

open access: yesPLoS ONE, 2018
The objective of this study was to evaluate the effect of low-dose naltrexone (LDN) as a carboplatin chemotherapy-associated drug in female dogs with mammary carcinoma in benign mixed tumors (MC-BMT) after mastectomy and to assess its association with ...
Marília Carneiro Machado   +8 more
doaj   +1 more source

Inflammatory and healing environment in synovial fluid after anterior cruciate ligament reconstruction: Granulocytes and endogenous opioids as new targets of postoperative pain

open access: yesBiochemistry and Biophysics Reports, 2021
Background: Biological processes after anterior cruciate ligament reconstruction (ACLR) is crucial for recovery. However, alterations in the of synovial fluid cell population during the acute phase following ACLR and the relationship between these cells ...
Hiroki Katagiri   +7 more
doaj   +1 more source

Soybean induced resistance to Spodoptera eridania herbivory

open access: yesPest Management Science, Volume 82, Issue 10, Page 9931-9943, October 2026.
SOD, CAT, APX, PPO, KTI, and MDA levels were higher in the resistant soybean. S. eridania herbivory increased H2O2 and MDA, but decreased SOD and PPO levels. S. eridania herbivory increased KTI activity only in the resistant variety. Isoquercitrin and daidzin were exclusive to resistant and susceptible soybeans.
Bruno Henrique Sardinha de Souza   +6 more
wiley   +1 more source

Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model-2

open access: yes, 2011
at week 10. . The expression of met-ENK after application of vehicle or HSV-β-gal is similar to naïve rats (). . Met-ENK expression was significantly increased in HSV-ENK vector-treated animals compared to controls.
Yong Ren (86476)   +7 more
core   +1 more source

Proopiomelanocortin (POMC)–β‐Endorphin System in the Rat Colon: Expression, Up Regulation by Stress, and Correlation With Stress‐Induced Visceral Analgesia

open access: yesNeurogastroenterology &Motility, Volume 38, Issue 10, October 2026.
This study identified a functional proopiomelanocortin–β‐endorphin system in the rat colon. Peripheral CRF and repeated water avoidance stress increased colonic POMC expression, which was associated with reduced visceral pain. These findings suggest that, outside the pituitary, a CRF‐ and stress‐sensitive enteric POMC–β‐endorphin system may help ...
Pu‐Qing Yuan   +3 more
wiley   +1 more source

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